Akinbo A. Adesomoju

Roseadione, a diterpene ketone from Hypoestes rosea

Abstract A tricyclic diterpene ketone, roseadione, has been isolated from Hypoestes rosea and its structure established as a dicyclopenta[ a , d ]cyclo

GC-MS identification of abscisic acid and abscisic acid metabolites in seed of Vigna unguiculata

Abscisic acid, phaseic acid and 4′-dihydrophaseic acid were identified by GC-MS of derivatized (Me, MeTMSi) extracts from immature fruits of Vigna unguiculata. The fruits also contained some other ABA-related compounds, one of which might be epi-4′-dihydrophaseic acid while another was tentatively identified as 6′-hydroxymethylabscisic acid.

Nigerian Sweet Orange Leaf Oil Composition

ABSTRACT The steam distilled oils from leaves of six different sweet orange cultivars were examined by GC/MS. Although twenty-eight constituents were identified in the oils, there were both qualitative and quantitative differences between them.

Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment

ETHNOPHARMACOLOGICAL SIGNIFICANCE Nigerian herbalists possess indigenous ethnomedicinal recipes for the management of tuberculosis and related ailments. A collaborative preliminary modern scientific evaluation of the efficacy of some Nigerian ethnomedicines used by traditional medicine practitioners (TMPs) in the management of tuberculosis and related ailments has been carried out. MATERIALS AND METHODS Ethnomedicinal recipes (ETMs) were collected from TMPs from locations in various ecological zones of Nigeria under a collaborative understanding. The aqueous methanolic extracts of the ETMs were screened against Mycobacterium bovis, BCG and Mycobacterium tuberculosis strain H37Rv using the broth microdilution method. RESULTS Extracts of ETMs screened against BCG showed 69% activity against the organism. The activities varied from weak, ≤2500 µg/mL to highly active, 33 µg/mL 64% of the extracts were active against Mycobacterium tuberculosis The activities of the extracts against Mycobacterium tuberculosis varied from weak, ≤2500 µg/mL to highly active, 128 µg/mL. There was 77% agreement in results obtained using BCG or Mycobacterium tuberculosis as test organisms. CONCLUSION The results show clear evidence for the efficacy of the majority of indigenous Nigerian herbal recipes in the ethnomedicinal management of tuberculosis and related ailments. BCG may be effectively used, to a great extent, as the organism for screening for potential anti-Mycobacterium tuberculosis agents. A set of prioritization criteria for the selection of plants for initial further studies for the purpose of antituberculosis drug discovery research is proposed.

Volatile Constituents of the Leaf Oil of Nigerian Lime (Citrus aurantifolia)

ABSTRACT Of the fifteen components identified by GC and GC/MS in the volatile leaf oil of lime (Citrus aurantifolia) from Nigeria, only limonene, geranial, nerol and β-pinene were found in substantial amounts. The volatile oil was obtained from the leaves by means of hydrodistillation.

Cimiciduphytine : a new dimeric indole alkaloid from Haplophyton cimicidum (Apocynaceae)

Cimiciduphytine, a new dimeric indole alkaloid from Haplophyton cimicidum (Apocynaceae) has been assigned the aspidosperma-canthinone bisindole structure

Leaf Volatile Oil Composition of Mandarin (Citrus reticulata) from Nigeria

ABSTRACT A combination of GC and GC/MS was used to characterize the chemical composition of the leaf oil of mandarin (Citrus reticulata) from Nigeria. A total of twenty-two compounds were identified in the oil. The main compounds were found to be γ- terpinene (20.15%), p-cymene (16.29%), linalool (9.55%) and terpinen-4-ol (7.13%).

Roseanolone: A New Diterpene from Hypoestes rosea

Abstract Roseanolone is a new diterpene from the African plant Hypoestes rosea (Acanthaceae). The isolation is described; the structure has been determined to be 1,2,3,3a,4,5,6,6a,7,8,9,10a-dodecahydro-5-hydroxy-3-isopropyl-3a, 6-oxa-6,9,10a-trimethyl-dicyclopenta[a,d] cycloocten-1-one by X-ray crystallography.

Composition of the Leaf Oil of Grapefruit (Citrus paradisi Macf.)

ABSTRACT The volatile components obtained from the leaves of Citrus paradisi Macf. (grapefruit) cv. redbush were examined by GC and GC/MS. Nineteen constituents were identified of which p-cymene, terpinen-4-ol, linalool and limonene were found to be most dominant in the oil.

The Composition of Lemon Petitgrain Oil (Citrus Limon (L.) N.L. Burm.)

ABSTRACT The essential oil of the leaves of lemon (Citrus limon) growing in Nigeria, which was produced by water distillation, was analyzed by GC and GC/MS. Fifteen mono and sesquiterpenoids were identified. Neral, geranial and limonene were the major components.