Akio Kamikawa
Astellas Pharma
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Publication
Featured researches published by Akio Kamikawa.
Bioorganic & Medicinal Chemistry | 2018
Hiromasa Oka; Koichi Yonezawa; Akio Kamikawa; Kazuhiro Ikegai; Norio Asai; Shohei Shirakami; Satoshi Miyamoto; Toshihiro Watanabe; Tetsuo Kiso; Yukihiro Takemoto; Seiji Tamura; Takahiro Kuramochi
A new series of transient receptor potential vanilloid type 1 (TRPV1) antagonists were designed and synthesized from N-(3-hydroxyphenyl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride (8). SAR studies identified (R)-N-(1-methyl-2-oxo-1,2,3,4-tetrahydro-7-quinolyl)-2-[(2-methylpyrrolidin-1-yl)methyl]biphenyl-4-carboxamide hydrochloride (ASP8370, 7), as a compound with high aqueous solubility, satisfactory stability in human liver microsomes, and reduced CYP3A4 inhibition. ASP8370 was selected as a clinical development candidate with significant ameliorative effects on neuropathic pain. SAR studies also revealed the structural mechanisms underlying the switching between TRPV1 antagonism and agonism.
Archive | 2010
Itsuro Shimada; Kazuo Kurosawa; Takahiro Matsuya; Kazuhiko Iikubo; Yutaka Kondoh; Akio Kamikawa; Hiroshi Tomiyama; Yoshinori Iwai
Archive | 2008
Yutaka Kondoh; Kazuhiko Iikubo; Sadao Kuromitsu; Nobuaki Shindo; Takatoshi Soga; Takashi Furutani; Itsuro Shimada; Takahiro Matsuya; Kazuo Kurosawa; Akio Kamikawa; Hiroyuki Mano
Archive | 2006
Junji Sato; Kazuyuki Hattori; Hirokazu Kubota; Ryosuke Munakata; Toru Asano; Junko Maeda; Masakatsu Kawakami; Akio Kamikawa
Archive | 2004
Toru Kontani; Junji Miyata; Wataru Hamaguchi; Tomoaki Kawano; Akio Kamikawa; Hiroshi Suzuki; Kenji Sudo
Archive | 2005
Junji Miyata; Masaki Yokota; Ryo Naito; Akio Kamikawa; Masakatsu Kawakami; Kazuyuki Hattori
Archive | 2007
Tatsuya Niimi; Akio Kamikawa; Yasushi Amano; Tomohiko Yamaguchi; Kenichi Suzumura; Kentaro Enjo; Takashi Furutani; Akio Kakefuda; Yutaka Kondoh; Masaaki Hirano
Archive | 2007
Tatsuya Niimi; Akio Kamikawa; Yasushi Amano; Tomohiko Yamaguchi; Kenichi Suzumura; Kentaro Enjo; Takashi Furutani; Akio Kakefuda; Yutaka Kondoh; Masaaki Hirano
Archive | 2010
Itsuro Shimada; Kazuo Kurosawa; Takahiro Matsuya; Kazuhiko Iikubo; Yutaka Kondoh; Akio Kamikawa; Hiroshi Tomiyama; Yoshinori Iwai
Archive | 2010
Itsuro Shimada; 逸郎 島田; Kazuo Kurosawa; 一雄 黒澤; Takahiro Matsuya; 松矢 高広; Kazuhiko Iikubo; 一彦 飯久保; Yutaka Kondoh; 近藤 裕; Akio Kamikawa; 晃雄 神川; Hiroshi Tomiyama; 冨山 泰; Yoshinori Iwai; 辰憲 岩井
