Akio Minato

Palladium-phosphine complex catalyzed cross-coupling reaction of 1-methyl-2-pyrrolyl-magnesium bromide and -zinc chloride with organic halides

Abstract 1-Methyl-2-pyrrolyl-magnesium bromide and -zinc chloride, which were prepared from 1-methyl-2-pyrrolyllithium with MgBr 2 and ZnCl 2 respectively, reacted with aryl- and heteroaromatic halides to give the corresponding 2-substituted pyrroles in good to excellent yields in the presence of palladium-phosphine complexes as catalysts.

Selective mono-alkylation and arylation of aromatic dihalides by palladium-catalyzed cross-coupling with the Grignard and organozinc reagents

Abstract Dibromobenzene, dibromothiophenes, dichloro- and dibromopyridine are highly selectively mono-alkylated and arylated with Grignard or organozinc reagents in the presence of palladium complexes as catalysts.

An efficient route to heteroarene-substituted vinyl- and allyl-silanes via palladium-phosphine complex catalyzed cross-coupling

Abstract Heteroarene-substituted vinyl- and allyl-silanes were obtained in good yields by the cross-coupling reaction of either heteroaryl Grignard reagents with halovinyl- and haloallyl-silanes or, alternatively, silyl- and silylmethyl-substituted vinylmetallic reagents with heteroaryl halides in the presence of PdCl 2 (dppb) as a catalyst.

Synthesis of a lignan skeleton via nickel- and palladium-phosphine complex catalyzed grignard coupling reaction of halothiophenes

Abstract A lignan skeleton is prepared in good yield through desulfurization of 3,4-dibenzyl-thiophene or 2,5-diaryl-3,4-dimethylthiophenes which are obtained by the nickel- or palladium-phosphine complex catalyzed Grignard cross-coupling reaction of halothiophenes.

Mixed heteroarene oligomers

Various types of mixed heteroatene oligomers can be readily prepared from heteroarene dihalides via stepwise coupling with heteroaryl Grignard reagents catalysed by a palladium–phosphine complex.