Akira Aizawa

Estimation of central aortic systolic pressure using late systolic inflection of radial artery pulse and its application to vasodilator therapy

Background: Central blood pressure (BP) is a useful predictor of cardiovascular risk. Recently, a fully automated device that measures central SBP (cSBP) from radial late SBP (rSBP2) has been developed. Method: We measured cSBP using this device, compared it with aortic SBP (aSBP) measured with a high-fidelity pressure sensor, and evaluated the accuracy of cSBP before and after vasodilator administration. The data of 66 patients (mean age, 63.4 ± 9.7 years; 49 men) who underwent cardiac catheterization were analyzed. The radial artery pulse waveform and brachial BP were measured sequentially and used to calculate cSBP. Brachial SBP and DBP were used for radial SBP (rSBP) and radial DBP to calculate the absolute value of rSBP2. The radial pulse waveform was recorded by an applanation tonometer (HEM-9000AI; Omron Healthcare Co. Ltd). A high-fidelity pressure sensor was placed in the ascending aorta, and aSBP was measured simultaneously by an invasive method. Results: Significant positive correlations between directly measured aortic late SBP and cSBP or rSBP were observed (r = 0.93, 0.88, respectively). Changes in aSBP before and after vasodilator administration showed a trend toward higher correlation with changes in cSBP than with changes in rSBP (r = 0.84, 0.78, respectively). The slope of the linear regression line of aSBP with cSBP (slope: 0.94) was closer to unity than with rSBP (0.66). Conclusion: Noninvasive cSBP calculated with rSBP2 accorded well with aSBP measured by the invasive method. Vasodilator medication and four of five diseases did not affect this relation.

Cross-Sectional Characterization of all Classes of Antihypertensives in Terms of Central Blood Pressure in Japanese Hypertensive Patients

BACKGROUND Central blood pressure (CBP) has been reported to be superior to brachial blood pressure (BP) as a cardiovascular risk predictor in hypertensive patients; however, the effects of antihypertensives on CBP have not been fully examined. This cross-sectional hypothesis-generating study aimed to tentatively characterize all classes of antihypertensives in relation to CBP. METHODS Calibrated tonometric radial artery pressure waveforms were recorded using an automated device in 1,727 treated hypertensive patients and 848 nonhypertensive (non-HT) participants. Radial artery late systolic BP (SBP) has been reported to reflect central SBP. The difference between late and peak SBPs (DeltaSBP2) was assessed with linear regression model-based adjustments. Separate regression models for DeltaSBP2 were constructed for both participant groups as well as specified sub-populations. RESULTS DeltaSBP2 was 3.3 mm Hg lower in patients treated with any single-vasodilating (VD) antihypertensive agent without significant interclass difference than with non-VD agents, and was 2.0 mm Hg lower than estimated in nonhypertensive subjects. Combinations of two vasodilators were 6.6 and 2.9 mm Hg lower in DeltaSBP2 than nonvasodilator combinations and nonhypertensive subjects, respectively (P < 0.001 for all comparisons). Nonvasodilators and their combination showed high DeltaSBP2, 1.1 and 3.7 mm Hg higher than in nonhypertensive subjects (P < 0.001 for both). Additional adjustment of the pulse rate reduced high DeltaSBP2 with beta-blockers (betaBLs). CONCLUSIONS This cross-sectional observation suggests that vasodilatory antihypertensives lower CBP independently of peripheral BP levels without evident class-specific differences, whereas nonvasodilators may raise CBP.