Akira Hakuba

The orbitozygomatic infratemporal approach : a new surgical technique

Lesions in the parasellar region and the interpeduncular fossa, including medial-third sphenoid wing meningiomas, petroclival meningiomas, trigeminal neurinomas, and basilar tip aneurysms, are very difficult to approach for radical procedures. To minimize brain retraction and achieve excellent exposure in the shortest possible distance for safe manipulation within these regions, the authors have developed a new surgical technique, an orbitozygomatic infratemporal approach. Sixteen patients with parasellar tumors, nine patients with basilar tip aneurysms, and one patient with a P-1 distal aneurysm were operated on using this orbitozygomatic infratemporal approach, with excellent results. The operative technique and its results are detailed.

A combined retroauricular and preauricular transpetrosal-transtentorial approach to clivus meningiomas

A combined retroauricular and preauricular transpetrosal-transtentorial approach is described for the resection of meningiomas arising from the clivus. Via radical mastoidectomy the sigmoid sinus is exposed down to the jugular bulb, and via the transmastoideal-subtemporal approach the retroauricular petrosal bone, 1 cm in depth from the petrosal ridge, and the roof of the internal auditory meatus are removed, the middle ear and fallopian canal being left intact. Additionally, via a transzygomatic-subtemporal approach the preauricular petrosal bone is removed anteriorly up to the petrosal tip and laterally as far as the petrosal portion of the internal carotid artery, while the cochlea is preserved. By this means, the triangular portion of the posterior petrosal dura mater, delimited by the superior petrosal sinus, inferior petrosal sinus, and sigmoid sinus, is well exposed extradurally. By opening the subtemporal and posterior petrosal dura mater, in combination with a tentoriotomy, adequate exposure of the basilar artery, vertebral arteries, ventral and lateral portions of the brainstem, and cranial nerves is achieved with minimal retraction of the temporal lobe and cerebellum.

Transpetrosal-transtentorial approach and its application in the therapy of retrochiasmatic craniopharyngiomas

Our experience with the transpetrosal-transtentorial approach to retrochiasmatic craniopharyngiomas is herein reviewed and an operative technique is described. Excellent exposure of the retrochiasmatic and suprasellar regions is gained with a minimal retraction of the temporal lobe and cerebellum. Eight cases of retrochiasmatic craniopharyngiomas that extended into the posterior hypothalamus were operated on utilizing this approach. The operative results were excellent in five patients, good in one, and poor in one. There was one death later. The principal advantage of this technique is that it allows the hypothalamus, even in cases in which the structure is remarkably displaced upwards, the third ventricular walls in cases of the intraventricular extension of the tumor, and the inferior surface of the optic chiasma and nerves to be visualized directly and thus safely preserved.

Expansive Suboccipital Cranioplasty for the Treatment of Syringomyelia Associated with Chiari Malformation

Summary In order to treat syringomyelia associated with adult type Chiari malformation, the authors developed a method of expansive suboccipital cranioplasty (ESC) that involves enlarging the small posterior fossa to obtain a sufficient flow of cerebrospinal fluid (CSF). The relative effectiveness of ESC with the obex plugged and not plugged was also examined, as well as other factors influencing the operative results. Twenty patients without arachnoid adhesion at the major cistern underwent ESC without opening the arachnoid membrane at the major cistern. After surgery, all improved with no recurrence and CSF flow study using magnetic resonance (MR) imaging showed significant improvement of the flow at the major cistern. Another 20 patients without arachnoid adhesion also underwent ESC but with obex plugging. Sixteen improved and one displayed only temporary improvement with recurrent syringomyelia due to postoperative arachnoid adhesions. The remaining three showed no change in spite of shrinkage of the syrinx on postoperative MR imaging. These three patients had displayed pre-operative symptoms over an approximately 10-year period involving almost the entire axial plain of the spinal cord, and presented a large syrinx before surgery. In 4 patients with arachnoid adhesions, all required intra-arachnoid procedures in addition to ESC. Intra-arachnoid procedures are not necessary to facilitate restoration of CSF flow in patients without arachnoid adhesions, because ESC can release the CSF flow blockage in the major cistern even without plugging of the obex. An associated arachnoid adhesion at the major cistern or a long-standing syringomyelia with irreversible damage of the spinal cord results in a poor operative prognosis. When posterior fossa surgery fails, insufficient decompression or postoperative arachnoid adhesions at the major cistern as the cause of treatments failure should be evaluated by CSF flow studies using phase contrast MR imaging.

MR appearance of Rathke's cleft cysts

SummaryTwo of three patients who proved to have symptomatic Rathkes cleft cysts presented with visual field deficit and all with diabetes insipidus. CT showed intra- and suprasellar cystic low density lesions with ring enhancement. MR showed intra-and suprasellar masses. On the T1-weighted images two of the three had hyperintense portions similar to fat and the other a hyperintense portion similar to white matter within the cysts. These portions were isointense to brain on the T2-weighted images in all cases. This characteristic intensity on MR images provides differentiation from cystic pituitary adenomas and cystic craniopharyngiomas, and leads to correct diagnosis of Rathkes cleft cyst.

Surgical outcome of intramedullary spinal cord ependymoma.

Summary Surgical outcome of intramedullary spinal cord ependymoma was investigated in order to define the treatment strategy. We have operated on 18 cases of intramedullary spinal cord ependymoma based on the principle of radical resection. The follow-up periods ranged from 10 months to 249 months with an average of 86.2 months. Postoperative neurological status in the long follow-up periods was compared to the pre-operative status and was correlated with the histological grade of malignancy. Total removal of the tumour was achieved in 17 cases, and subtotal removal followed by radiation therapy was conducted in 1 case. There was neither surgical mortality nor radiological evidence of recurrence in the long-term follow-up periods. The final outcome of the neurological condition was improved in 1 case, unchanged in 15 cases (including a case of subtotal removal) and deteriorated in 2 cases. The deterioration was in the form of gait disturbance due to the worsening of proprioception in 2 cases and dysaethesia in 1 case. Histological examination showed no evidence of anaplasia in 6 cases, evidence of early anaplasia in 10 cases, and moderate evidence of anaplasia in 2 cases. No relationship between the histological malignancy and clinical course was found. Intramedullary spinal cord ependymoma should be removed radically as early as possible while taking great care to avoid posterior column injury. Histologically malignant ependymoma might be a clinical exception.

Suckling Dysfunction Caused by Defects in the Olfactory System in Genetic Arhinencephaly Mice

Mouse newborns find their mother’s nipples and suckle milk by themselves. It has been argued which sense organ they use when locating their mother’s nipples to suckle milk. Olfactory or tactile sensory systems are primary candidates. In the present study, we investigated the trigeminal-whisker sensory and olfactory systems in genetic arhinencephaly mouse embryos (Pdn/Pdn). Pdn/Pdn newborns do not suckle milk and die within 1 day after birth. Dysfunction of nipple-searching behavior was clear in Pdn/Pdn newborns. Pdn/Pdn newborns had a complete developmental failure in the olfactory nerve projection to the central nervous system and no olfactory bulb architecture. The trigeminal-whisker system was intact in this strain. From the results of these experiments, it was suggested that the olfactory system is essential for nipple-searching behavior and suckling milk and that the trigeminal-whisker system is not able to substitute for the lack of olfactory input in mouse newborns.

MR imaging of intraspinal tumors--capability in histological differentiation and compartmentalization of extramedullary tumors.

SummaryMagnetic resonance (MR) images of 29 consecutive patients with intraspinal neoplasms (9 intramedullary tumors, 20 extramedullary tumors) were reviewed to evaluated the utility of MR imaging in distinguishing the intraspinal compartmental localisation and signal characteristics of each lesion. Compartment and histology of all neoplasms were surgically proven. MR correctly assigned one of three compartments to all lesions, 9 intramedullary, 14 intradural extramedullary (6 schwannomas, 3 neurofibromas, 5 meningiomas), and 6 extradural (3 schwannomas, 1 meningioma, 1 cavernous hemangioma, 1 metastatic renal cell carcinoma). All intramedullary tumors showed swelling of the spinal cord itself. In all five extradural tumors a low intensity band was visualized between the spinal cord and tumor. On the other hand, a low intensity band was demonstrated in no cases with intradural tumors. Visualization of this low intensity band is important in differentiating extradural from intradural-extramedullary lesions. We call this low intensity band, “the extradural sign”. Signal intensity of intradural tumors varied with histology. In extramedullary tumors, signal intensity of schwannomas was similar to that of the cerebrospinal fluid (CSF) both on T1 weighted (inversion recovery) and T2 weighted spin echo (SE) images. On the other hand, meningiomas tended to be isointense to the spinal cord on both T1 and T2 weighted SE images. We found relatively reliable signal characteristics to discriminate meningioma from schwannoma.

Lymphocytic adenohypophysitis: skull radiographs and MRI

Abstract We report the skull radiograph, CT and MRI findings in three patients with lymphocytic adenohypophysitis mimicking pituitary adenoma. All cases were associated with pregnancy. CT demonstrated a pituitary mass but did not differentiate lymphocytic adenohypophysitis from pituitary adenoma. The skull radiographs showed either a normal sella turcica or minimal abnormalities; they did not show ballooning or destruction. The MRI appearances were distinctive: relatively low signal on T1-weighted images; preservation of the bright posterior pituitary lobe despite the presence of a relatively large pituitary mass, less common in macroadenomas; marked contrast enhancement compared with pituitary macroadenomas; and dural enhancement adjacent to a pituitary mass.

Facial nerve neuromas: CT findings.

Although neuromas of the facial nerve are rare, they present with uniform clinical and radiological findings. Their pluridirectional tomography findings have been well described; however, the appearance of the intracranial extension of the neuroma which is best visualized by CT has not been emphasized. We report five cases of facial nerve neuromas with particular attention to their intracranial extension. For comparative purposes we also have reviewed 10 cases of acoustic and eight cases of trigeminal neuromas, all involving the cerebellopontine angle (CPA) and the middle cranial fossa. Two of the five facial nerve neuromas affected the second and third segments of the facial canal, and three involved both the CPA and the middle cranial fossa spreading across the midpetrosal bone. This type of tumor extension seems to be characteristic of facial nerve neuromas. In acoustic and trigeminal neuromas the tumor crossing toward the middle fossa takes place via the tentorial hiatus (acoustic) and the petrous apex (trigeminal).