Akira Iizuka
Laboratory of Molecular Biology
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Publication
Featured researches published by Akira Iizuka.
Journal of Ethnopharmacology | 1998
Akira Iizuka; Osamu T. Iijima; Fumihiko Yoshie; Bunsho Makino; Sakae Amagaya; Yasuhiro Komatsu; Kazuo Kondo; Akiyo Matsumoto; Hiroshige Itakura
The inhibitory effects of the traditional herbal medicine Dai-saiko-to (Da-Chai-Hu-Tang) on the progression of the atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Changes in blood chemistry, pathology and low-density lipoprotein (LDL) oxidation were measured in a control group and a Dai-saiko-to-treated group. In the control group, the area of atheromatous plaques of the aorta progressed between week 12 (29.1%) and 26 (51.5%). This progression of atherosclerotic lesions did not happen in the Dai-saiko-to-treated group between week 12 (26%) and 26 (27.4%). Antioxidative effects on LDL were seen in the Dai-saiko-to-treated group in weeks 16 and 18. Dai-saiko-to did not improve the hypercholesterolemia in the KHC rabbits. These results suggest that Dai-saiko-to has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH model rabbits. It is possible that the antioxidative effects of Dai-saiko-to on LDL led to the beneficial effects observed in this study.
Journal of Ethnopharmacology | 2004
Akira Iizuka; Osamu T. Iijima; Kazuo Kondo; Hiroshige Itakura; Fumihiko Yoshie; Hiroko Miyamoto; Masayoshi Kubo; Masami Higuchi; Hiroshi Takeda; Teruhiko Matsumiya
Biological & Pharmaceutical Bulletin | 1998
Masato Fukutake; Shigeru Yokota; Hideki Kawamura; Akira Iizuka; Sakae Amagaya; Kazunori Fukuda; Yasuhiro Komatsu
Japanese Journal of Pharmacology | 1996
Yuka Okui; Masufumi Morita; Akira Iizuka; Yasuhiro Komatsu; Minoru Okada; Masao Maruno; Akira Niijima
Pharmacological Research | 2001
Fumihiko Yoshie; Akira Iizuka; Masayoshi Kubo; Yasuhiro Komatsu; Akiyo Matsumoto; Hiroshige Itakura; Hiroshi Takeda; Teruhiko Matsumiya; Kazuo Kondo
Journal of Atherosclerosis and Thrombosis | 2000
Akira Iizuka; Osamu T. Iijima; Kazuo Kondo; Akiyo Matsumoto; Hiroshige Itakura; Fumihiko Yoshie; Yasuhiro Komatsu; Hiroshi Takeda; Teruhiko Matsumiya
Journal of Ethnopharmacology | 2005
Masaru Sakaguchi; Kazuhiro Goto; Hiroyuki Ichiki; Naoko Hattori; Akira Iizuka; Masahiro Yamamoto; Shuichi Takeda; Atsushi Ishige; Masaki Aburada; Masako Yasuda; Toshinori Yamamoto
Pharmacological Research | 2004
Fumihiko Yoshie; Akira Iizuka; Yasuhiro Komatsu; Akiyo Matsumoto; Hiroshige Itakura; Kazuo Kondo
Japanese Journal of Pharmacology | 2000
Yoshiki Ikeda; Akira Iizuka; Sakae Amagaya; Atsushi Ishige; Yasuhiro Komatsu; Eiichi Fujihira
American Journal of Plant Sciences | 2013
Akira Iizuka; Fumihiko Yoshie; Sakae Amagaya; Takaaki Yasuda; Maki Iizuka; Haruyo Yamaguchi; Seiji Nagumo; Kazuo Kondo
