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Akira Nozuhara

Kurume University

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Publication

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Biochemical and Biophysical Research Communications | 1991

Vitamin E deficiency has a pathological role in myocytolysis in cardiomyopathic Syrian hamster (BIO14.6).

Toshihiko Sakanashi; Shigeki Sako; Akira Nozuhara; Kyo Adachi; Toshiaki Okamoto; Yoshinori Koga; Hironori Toshima

This study revealed the occurrence of vitamin E deficiency in the myocardium of 60-day-old Syrian cardiomyopathic hamsters (BIO14.6), and that this deficiency might be related to the increase in lipid peroxide. Vitamin E administration for ten days effectively restored creatininekinase activity and decreased the lipid peroxide content in the myocardium, returning these to normal control levels (F1b). These results indicate that vitamin E deficiency, possibly combined with oxidative stress in the early cardiomyopathic stage plays an important role in initiating the pathogenesis of myocardial lesions.

Biochemical and Biophysical Research Communications | 1993

A Deletion of Mitochondrial DNA in Murine Doxorubicin-Induced Cardiotoxicity

Kyo Adachi; Y. Fujiura; F. Mayumi; Akira Nozuhara; Yuji Sugiu; Toshihiko Sakanashi; T. Hidaka; Hironori Toshima

Japanese Circulation Journal-english Edition | 1994

DETECTION OF CATECHOLAMINE-INDUCED DNA SINGLE STRAND BREAKS BY THE ALKALINE ELUTION METHOD

Toshiaki Okamoto; Kyo Adachi; Fumihito Mayumi; Toshihiko Sakanashi; Yuji Sugiu; Shuzo katsuki; Akira Nozuhara; Hironori Toshima

The Kurume Medical Journal | 1993

Evaluation of the Intramembrane Particle Count in Biopsied Myocardium from Patients with Idiopathic Cardiomyopathy

Kyo Adachi; Yoshinao Yamashita; Akira Nozuhara; Yuji Sugiu; Hironori Toshima

Japanese Circulation Journal-english Edition | 1993

Free Radical Production Has an Important Role in Disturbance in Myocardial Functions in Cardiomyopathy Hamsters : Vitamin E improves myocardial damage and survival : Biochemical analysis of myocardial dysfunction

Toshihiko Sakanashi; Akira Nozuhara; Shigeki Sako; Kyo Adachi; Yoshinori Koga; Hironori Toshima

Japanese Circulation Journal-english Edition | 1992

[Free radical production has an important role in disturbance in myocardial functions in cardiomyopathy hamsters--vitamin E improves myocardial damage and survival].

Toshihiko Sakanashi; Akira Nozuhara; Shigeki Sako; Kyo Adachi; Yoshinori Koga; Hironori Toshima

Japanese Circulation Journal-english Edition | 1990

-0028-PROGRESSIVE MEMBRANE DISORDERS IN CARDIOMYOPATHIC HAMSTERS(BIO 14.6)

Akira Nozuhara; Toshihiko Sakanashi; Shigeki Sako; Kiichiro Yamamoto; Fumihito Mayumi; Kyo Adachi; Yoshinori Koga; Hironori Toshima; Ryohei Ogura

Japanese Circulation Journal-english Edition | 1990

-0648-DETECTION OF THE COXSACKIE B3 VIRUS GENOMES IN THE HEART OF MICE WITH EXPERIMENTAL VIRAL MYOCARDITIS USING POLYMERASE CHAIN REACTION (PCR) TECHNIQUE

Kiichiro Yamamoto; Kyo Adachi; Fumihito Mayami; Toshihiko Sakanashi; Shigeki Sako; Akira Nozuhara; Hiroyuki Tanaka; Hironori Toshima

Japanese Circulation Journal-english Edition | 1990

-0659-DIFFERENT COMPOSITION OF THE EXTRACELLULAR MATRIX BETWEEN MYOCARDIAL DISEASES : AN IMMUNOHISTOCHEMICAL STUDY

Fumihito Mayumi; Kiichiro Yamamoto; Toshihiko Sakanashi; Kyo Adachi; Shigeki Sako; Akira Nozuhara; Yoshio Hidaka; Hiroyuki Tanaka; Hironori Toshima

Japanese Circulation Journal-english Edition | 1989

EXPRESSION OF PROTEIN KINASE C (PKC) IN IDIOPATHIC CARDIOMYOPATHY : IMMUNOHISTOCHEMISTRY OF ENDOMYOCARDIAL BIOPSIES : Cardiomyopathy, Myocarditis : 53 Annual Scientific Meeting, Japanese Circulation Society

Toshihiko Sakanashi; Kyo Adachi; Shigeki Sako; Fumihito Mayumi; Kiichiro Yamamoto; Yoshio Hidaka; Akira Nozuhara; Yoshinori Koga; Hironori Toshima

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Hironori Toshima

Kurume University

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Kyo Adachi

Kurume University

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Toshihiko Sakanashi

Kurume University

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Shigeki Sako

Kurume University

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Kiichiro Yamamoto

Kurume University

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Yoshinori Koga

University of Minnesota

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Yuji Sugiu

Kurume University

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Hiroyuki Tanaka

Tokyo Medical and Dental University

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Toshiaki Okamoto

Kurume University

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Yoshinori Koga

University of Minnesota

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