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Akira Okuyama

Merck & Co.

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Publication

Featured researches published by Akira Okuyama.

Biochemistry | 1997

MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4.

Kayoko Ookata; Shin-ichi Hisanaga; Minoru Sugita; Akira Okuyama; Hiromu Murofushi; Hidefumi Kitazawa; Sripriya Chari; Jeannette Chloë Bulinski; Takeo Kishimoto

Journal of Biochemistry | 1995

Evidence for cdk5 as a Major Activity Phosphorylating Tau Protein in Porcine Brain Extract

Tomoko Hosoi; Masashi Uchiyama; Eiichi Okumura; Taro Saito; Koichi Ishiguro; Tsuneko Uchida; Akira Okuyama; Takeo Kishimoto; Shin-ichi Hisanaga

International Journal of Cancer | 1994

Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor

Kyozo Naito; Nobuo Kanbayashi; Shigeru Nakajima; Takashi Murai; Kyoko Arakawa; Susumu Nishimura; Akira Okuyama

Biochemical and Biophysical Research Communications | 1996

DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin.

Yukinori Take; Mariko Kumano; Hirobumi Teraoka; Susumu Nishimura; Akira Okuyama

FEBS Journal | 1996

Cyclin-Dependent Kinase-2 (Cdk2) Forms an Inactive Complex with Cyclin D1 Since Cdk2 Associated with Cyclin D1 is Not Phosphorylated by Cdk7–Cyclin-H

Hideaki Higashi; Ikuko Suzuki-Takahashi; Shio Saitoh; Kaoru Segawa; Yoichi Taya; Akira Okuyama; Susumu Nishimura; Masatoshi Kitagawa

Biochemical and Biophysical Research Communications | 1995

OK-1035, a Selective Inhibitor of DNA-Dependent Protein Kinase

Y. Take; M. Kumano; Y. Hamano; H. Fukatsu; H. Teraoka; Susumu Nishimura; Akira Okuyama

Biochemical and Biophysical Research Communications | 1994

Inhibition of cell cycle oscillation of DNA replication by a selective inhibitor of the cdc2 kinase family, butyrolactone I, in Xenopus egg extracts

Akira Someya; Nobuo Tanaka; Akira Okuyama

Annals of the New York Academy of Sciences | 1994

Inhibition of Growth of Human Tumor Cells in Nude Mice by a Metalloproteinase Inhibitor

Akira Okuyama; Kyozo Naito; Hajime Morishima; Hiroyuki Suda; Susumu Nishimura; Nobuo Tanaka

Biochemical and Biophysical Research Communications | 1993

Inhibition of Initiation of DNA Replication in Xenopus Egg Extracts by a Phosphatase Inhibitor, Calyculin A

Akira Someya; Nobuo Tanaka; Akira Okuyama

Experimental Cell Research | 1995

Appearance of Rereplication and Activation of DNA Replication by Calyculin A in a Cell-Free Extract of Activated Xenopus Eggs

Akira Someya; Nobuo Tanaka; Akira Okuyama

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Susumu Nishimura

Merck

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Nobuo Tanaka

Merck

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Kyozo Naito

Merck

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Akira Someya

University of Tokyo

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Nobuo Tanaka

Merck

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Shin-ichi Hisanaga

Tokyo Metropolitan University

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Takeo Kishimoto

Tokyo Institute of Technology

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A. Honda

Merck

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A. Someya

Merck

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Akira Someya

University of Tokyo

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