Akiyo Kameyama
Kao Corporation
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Akiyo Kameyama.
FEBS Letters | 2006
Atsushi Suzuki; Akihiko Fujii; Naoki Yamamoto; Masaki Yamamoto; Hideo Ohminami; Akiyo Kameyama; Yusuke Shibuya; Yoshinori Nishizawa; Ichiro Tokimitsu; Ikuo Saito
Chlorogenic acid, a polyphenol found in coffee, has antihypertensive actions, but epidemiologic data on the effects of coffee on blood pressure are controversial. Specific coffee components that inhibit the hypotensive effect of chlorogenic acid and the physiologic mechanisms underlying the effects of coffee without these components were investigated. One component, hydroxyhydroquinone (HHQ), inhibited the hypotensive effects of chlorogenic acid in spontaneously hypertensive rats (SHR). The attenuation of hypertension by HHQ‐free coffee was associated with nitric oxide, the suppression of mRNA expression of NAD(P)H oxidase, and the improvement in endothelium‐dependent vasodilation in the aorta. Thus, HHQ‐free coffee might regulate vascular tone by improving the bioavailability of nitric oxide in SHR.
Tetrahedron Letters | 2003
Akiyo Kameyama; Yusuke Shibuya; Hiroshi Kusuoku; Yoshinori Nishizawa; Satoshi Nakano; Kuniaki Tatsuta
Abstract As the first natural product incorporating 1,3-dioxolan-4-one in spiro structure, spilacleosides A and B were isolated from Ruscus aculeatus , and the absolute structures determined.
Journal of Natural Medicines | 2014
Shinya Kasamatsu; Akira Hachiya; Yoshie Shimotoyodome; Akiyo Kameyama; Yuki Miyauchi; Kazuhiko Higuchi; Taketoshi Fujimori; Atsushi Ohuchi; Yusuke Shibuya; Takashi Kitahara
The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring melanocytes via their Kit receptors. In order to identify effective skin-lightening materials, we screened botanical extracts to determine their abilities to diminish Kit expression in melanocytes. A Platycodon root extract was consequently found to have a remarkable inhibitory activity on Kit expression. When the extract was applied to three-dimensional human skin substitutes in vitro and to human skin in vivo after UVB irradiation, their pigmentation was significantly reduced, confirming the substantial contribution of the suppression of SCF/Kit signaling to preventing or inhibiting melanin synthesis. These data demonstrate that a Platycodon root extract is a promising material for a skin-lightening product to improve pigmentation-related diseases.
Archive | 2000
Masahide Hoshino; Yoshiya Sugai; Akiyo Kameyama; Hiroaki Saito; Yoshinori Nishizawa; Yutaka Takagi
Archive | 2013
Maeko Iwamura; Akiyo Kameyama; Yoriko Nakagiri; Takashi Nishijima; 頼子 中桐; 明代 亀山; 真恵子 岩村; 貴史 西島
Archive | 2011
Akiyo Kameyama; Sachie Ueda
Archive | 2009
Akiyo Kameyama; Tsutomu Fujimura
Archive | 2011
Sachie Ueda; 早智江 上田; Hiroyuki Taguchi; 浩之 田口; Akiyo Kameyama; 明代 亀山
Archive | 2009
Akiyo Kameyama; Tsutomu Fujimura
Archive | 2009
Akiyo Kameyama; Tsutomu Fujimura