Al Pinna

Cutaneous adverse drug reactions to allopurinol: 10 year observational survey of the dermatology department – Cagliari University (Italy)

Background  Allopurinol is extensively prescribed for conditions associated with urate excess, despite being responsible for severe cutaneous adverse drug reactions (ADR).

Clinical efficacy and tolerability of terbinafine in patients with pityriasis versicolor

Summary. The antifungal efficacy and tolerability of 1% terbinafine cream vs. 1% bifonazole cream were assessed in a single blind randomized trial in patients with pityriasis versicolor. Terbinafine, a drug of the allylamines group, a new class of antimycotic agents, blocks sterol biosynthesis in the pathogen through inhibition of squalene epoxidase and consequent squalene accumulation, a primarily fungicidal process. Forty pityriasis versicolor patients, (18 M, 22 F; mean age 32.4 years; min. 16, max. 65), used 1% terbinafine cream or 1% bifonazole cream for a maximum of 4 weeks. All patients were followed‐up weekly both clinically and my‐cologically. Clinical cures, defined as negativization of each clinical parameter, were recorded for 20 terbinafine patients (100%) and 19 bifonazole patients (95%), with routine microscopy and Woods light tests both negative. By the 2nd week of treatment, 2 terbinafine patients were mycologically cured (10%). By the 3rd week, 14 terbinafine patients (70%) and 5 bifonazole patients (25%) were mycologically cured. The present controlled clinical trial consequently demonstrates that terbinafine is rapidly effective and well tolerated for treatment of pityriasis versicolor.

Amniotic membrane transplantation in the surgical management of symblepharon following toxic epidermal necrolysis

Toxic epidermal necrolysis (TEN) is a rare, potentially life-threatening acute condition, whose pathophysiology is not completely understood, but there is a certain agreement that it consists of a cell-mediated cytotoxic reaction against keratinocytes, altered by drugs or their metabolites. 1–3 Early recognition and withdrawal of the suspected drug are the main recommended procedures. 3 Therapeutic goals in the acute phase are directed toward promotion of wound healing, prevention of sepsis and management of multisystem failure. 4 In those patients who survive, ocular complications represent the most significant long-term sequelae and occurs in about 50% of cases. 5

Granulomatous reactions after injections of multiple aesthetic micro-implants in temporal combinations: a complication of filler addiction

Granulomatous reaction is a well‐known complication following soft filler procedures. However, the diagnosis of filler‐induced granulomas may be challenging because of the occasional reluctance of patients to report the previously performed aesthetic procedure.

Methimazole-induced chronic cutaneous lupus erythematosus.

T. Dainichi, T. Tanaka, K. Izawa, R. Nishikomori, K. Kabashima* Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore *Correspondence: S. Nakamizo and K. Kabashima. E-mails: s.nakami@ kuhp.kyoto-u.ac.jp; kaba@kuhp.kyoto-u.ac.jp