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Dive into the research topics where Alain Merschaert is active.

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Featured researches published by Alain Merschaert.


Tetrahedron Letters | 2003

New stereoselective syntheses of cis- and trans-2-methyl-4-arylpiperidines

Alain Merschaert; Laurent Delhaye; Jean-Paul Kestemont; Willy Brione; Pieter Delbeke; Vincent Mancuso; Freddy Andre Napora; Khalid Diker; Daniel Giraud; Michel Vanmarsenille

A stereoselective approach has been developed for the synthesis of cis- and trans-2-methyl-4-arylpiperidines from a common intermediate. The Ni-catalyzed hydrogenolysis of N-Boc-2-methyl-4-aryl-4-piperidinols, obtained by addition of organometallic reagents on N- Boc-2-methyl-4-piperidone, afforded the trans derivatives with Lip to 95% selectivity whereas the corresponding cis isomers were obtained in the presence of palladium catalysts


Tetrahedron Letters | 2004

The rational design of modified cinchona alkaloid catalysts. Application to a new asymmetric synthesis of chiral chromanes

Alain Merschaert; Pieter Delbeke; Désiré Daloze; Georges Dive


Organic Process Research & Development | 2006

Mild and safer preparative method for nonsymmetrical sulfamides via N-sulfamoyloxazolidinone derivatives: Electronic effects affect the transsulfamoylation reactivity

Alfio Borghese; Luc Antoine; J. P. Van Hoeck; and Anne Mockel; Alain Merschaert


Archive | 2006

IMPROVED PROCESS FOR THE ASYMMETRIC SYNTHESIS OF DULOXETINE

Mark Anthony Butchko; Alain Merschaert; Kenneth Philip Moder


Organic Process Research & Development | 2006

Novel approaches towards the LTD4/e4 antagonist, LY290154

Alain Merschaert; Pascal Boquel; Jean-Pierre Van Hoeck; Hugo Gorissen; Alfio Borghese; Benjamin Bonnier; and Anne Mockel; Freddy Andre Napora


Tetrahedron Letters | 2006

The ring opening of 3,4-dichloro-1,2,5-thiadiazole with metal amides. A new synthesis of 3,4-disubstituted-1,2,5-thiadiazoles

Alain Merschaert; Pascal Boquel; Hugo Gorissen; Jean-Pierre Van Hoeck; Alfio Borghese; Luc Antoine; Vincent Mancuso; Anne Mockel; Michel Vanmarsenille


Archive | 2006

Process for the asymmetric synthesis of duloxetine

Mark Anthony Butchko; Alain Merschaert; Kenneth Philip Moder


Synthesis | 2006

Synthesis of 4,4′-Disubstituted Azepines via Ring-Closing Metathesis Reaction and Asymmetric Arylation of Lactones

Laurent Delhaye; Alain Merschaert; Khalid Diker; Ioannis N. Houpis


Tetrahedron Letters | 2015

Acid catalyzed nitrile thiolysis of 3-amino-acrylonitriles, toward the synthesis of 3,4-substituted-5-amino-isothiazoles

Steven L. Kuklish; Ryan T. Backer; Matthew Joseph Fisher; Aaron M. Kempema; Scott C. Mauldin; Alain Merschaert


Organic Process Research & Development | 2006

Novel Approaches towards the LTD 4 /E 4 Antagonist, LY290154

Alain Merschaert; Pascal Boquel; Jean-Pierre Van Hoeck; Hugo Gorissen; Alfio Borghese; Benjamin Bonnier; Anne Mockel; Freddy Andre Napora

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Pascal Boquel

Centre national de la recherche scientifique

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Anne Mockel

Université catholique de Louvain

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Désiré Daloze

Université libre de Bruxelles

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Vincent Mancuso

Université libre de Bruxelles

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