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Alain Rolland

Ipsen

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Publication

Featured researches published by Alain Rolland.

Bioorganic & Medicinal Chemistry Letters | 1999

BN 80927: A NOVEL HOMOCAMPTOTHECIN WITH INHIBITORY ACTIVITIES ON BOTH TOPOISOMERASE I AND TOPOISOMERASE II

Olivier Lavergne; Jeremiah Harnett; Alain Rolland; Christophe Lanco; Laurence Lesueur-Ginot; Danièle Demarquay; Marion Huchet; Hélène Coulomb; Dennis Bigg

BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.

Journal of Medicinal Chemistry | 1998

Homocamptothecins : Synthesis and antitumor activity of novel E-ring-modified camptothecin analogues

Olivier Lavergne; Laurence Lesueur-Ginot; Francesc Pla Rodas; Philip G. Kasprzyk; Jacques Pommier; Danièle Demarquay; Gregoire Prevost; Gerard Ulibarri; Alain Rolland; § Anne-Marie Schiano-Liberatore; Jeremiah Harnett; Dominique Pons; and José Camara; Dennis Bigg

Bioorganic & Medicinal Chemistry Letters | 2004

Phenolic thiazoles as novel orally-active neuroprotective agents

Jeremiah Harnett; Véronique Roubert; Christine Dolo; Christelle Charnet; Brigitte Spinnewyn; Sylvie Cornet; Alain Rolland; Jean-Gregoire Marin; Dennis Bigg; Pierre-E. Chabrier

Journal of Organic Chemistry | 2006

Practical formal total syntheses of the homocamptothecin derivative and anticancer agent diflomotecan via asymmetric acetate aldol additions to pyridine ketone substrates.

René Peters; Martin Althaus; Christian Diolez; Alain Rolland; Eric Manginot; Marc Veyrat

Archive | 1997

Pro-drugs and counterparts of camptothecin, their application as medicines

Dennis Bigg; Olivier Lavergne; Jerry Harnett; Alain Rolland; Anne-Marie Liberatore; Christophe Lanco

Archive | 1998

Novel camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them

Dennis Bigg; Olivier Lavergne; Alain Rolland; Christophe Lanco; Gerard Ulibarri

Archive | 2002

5-membered heterocycles, preparation and use thereof as mao inhibitors and lipid peroxidation inhibitors, preparation thereof and use thereof as medicaments

Jeremiah Harnett; Dennis Bigg; Anne-Marie Liberatore; Alain Rolland

Heterocycles | 2007

Practical racemic and asymmetric formal total syntheses of the homocamptothecin derivative and anticancer agent diflomotecan via tertiary homoallylic alcohols as masked aldol equivalents

René Peters; Christian Diolez; Alain Rolland; Eric Manginot; Marc Veyrat

Archive | 2000

Optically pure camptothecin analogues

Olivier Lavergne; Dennis Bigg; Christophe Lanco; Alain Rolland

Archive | 2000

New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them

Dennis Bigg; Olivier Lavergne; Alain Rolland; Christophe Lanco; Gerard Ulibarri

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Collaboration

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Olivier Lavergne

Ipsen

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Christophe Lanco

Ipsen

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Dennis Bigg

Ipsen

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Anne-Marie Liberatore

Ipsen

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Dennis Bigg

Ipsen

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Jeremiah Harnett

Ipsen

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Christian Diolez

Ipsen

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Eric Manginot

Ipsen

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Anne Brochard

Ipsen

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Bertrand Poirot

Ipsen

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