Alain Truchon

Synthesis of RP-67,580, a new potent nonpeptide substance P antagonist

Abstract The synthesis of enantiomerically pure RP-67,580, a novel nonpeptide Substance P receptor antagonist, is described as well as the resolution of intermediate perhydroisoindolone.

Perhydrothiopyranopyrroles derivatives : A novel series of potent and selective nonpeptide NK1 antagonists.

The synthesis of RP 73467, a representative of 4,4-diphenyl perhydrothiopyrano[2,3-c]-pyrroles 1-oxides, a new series of potent and selective nonpeptide NK1 Substance P antagonists, is described.

5,6-Dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinoline-2,2-dioxide: A New N,N'-Cyclic Sulfamide

The title compound and its potassium salt were prepared in two steps, starting from 8-nitroquinoline