Alan D. Martin

Calcium Accretion in Girls and Boys During Puberty: A Longitudinal Analysis

The primary purpose of this study was to estimate the magnitude and variability of peak calcium accretion rates in the skeletons of healthy white adolescents. Total‐body bone mineral content (BMC) was measured annually on six occasions by dual‐energy X‐ray absorptiometry (DXA; Hologic 2000, array mode), a BMC velocity curve was generated for each child by a cubic spline fit, and peak accretion rates were determined. Anthropometric measures were collected every 6 months and a 24‐h dietary recall was recorded two to three times per year. Of the 113 boys and 115 girls initially enrolled in the study, 60 boys and 53 girls who had peak height velocity (PHV) and peak BMC velocity values were used in this longitudinal analysis. When the individual BMC velocity curves were aligned on the age of peak bone mineral velocity, the resulting mean peak bone mineral accrual rate was 407 g/year for boys (SD, 92 g/year; range, 226–651 g/year) and 322 g/year for girls (SD, 66 g/year; range, 194–520 g/year). Using 32.2% as the fraction of calcium in bone mineral, as determined by neutron activation analysis (Ellis et al., J Bone Miner Res 1996;11:843‐848), these corresponded to peak calcium accretion rates of 359 mg/day for boys (81 mg/day; 199–574 mg/day) and 284 mg/day for girls (58 mg/day; 171–459 mg/day). These longitudinal results are 27–34% higher than our previous cross‐sectional analysis in which we reported mean values of 282 mg/day for boys and 212 mg/day for girls (Martin et al., Am J Clin Nutr 1997;66:611‐615). Mean age of peak calcium accretion was 14.0 years for the boys (1.0 years; 12.0‐15.9 years), and 12.5 years for the girls (0.9 years; 10.5‐14.6 years). Dietary calcium intake, determined as the mean of all assessments up to the age of peak accretion was 1140 mg/day (SD, 392 mg/day) for boys and 1113 mg/day (SD, 378 mg/day) for girls. We estimate that 26% of adult calcium is laid down during the 2 adolescent years of peak skeletal growth. This period of rapid growth requires high accretion rates of calcium, achieved in part by increased retention efficiency of dietary calcium.

Factors associated with exercise adherence among older adults. An individual perspective.

AbstractThis paper reviews the literature concerning factors at the individual level associated with regular exercise among older adults. Twenty-seven cross-sectional and 14 prospective/longitudinal studies met the inclusion criteria of a mean participant age of 65 years or older. The findings are summarised by demographics, exercise experience, exercise knowledge, physiological factors, psychological factors, activity preferences and perceived social influences. In general, education and exercise history correlate positively with regular exercise, while perceived physical frailty and poor health may provide the greatest barrier to exercise adoption and adherence in the elderly. Social-cognitive theories identify several constructs that correlate with the regular exercise behaviour of older adults, such as exercise attitude, perceived behavioural control/self-efficacy, perceived social support and perceived benefits/barriers to continued activity. As well, stage modelling may provide additional information about the readiness for regular exercise behaviour among older adults. However, relatively few studies among older adults exist compared with middle-aged and younger adults. Further, the majority of current research consists of cross-sectional designs or short prospective exercise trials among motivated volunteers that may lack external validity. Future research utilising longitudinal and prospective designs with representative samples of older adults will provide a better understanding of significant causal associations between individual factors and regular exercise behaviour.

Cigarette Smoking, Steroid Hormones, and Bone Mineral Density in Young Women

SummaryThere are few studies of the effect of smoking on bone density in young women. The reported antiestrogenic effect of smoking could be a mechanism for a possible effect of smoking on bone. We measured bone mineral density (BMD) by dual-energy X-ray absorptiometry (whole body, proximal femur, lumbar spine), and serum levels (midfollicular phase) of testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), and cortisol in 52 women (25 smokers, 27 nonsmokers) aged 20–35 years. The two groups did not differ significantly in age, height, weight, or the sum of eight skinfold thicknesses. The mean number of cigarettes smoked per day and the number of years of smoking were 16.9 and 12.9, respectively. There were no significant differences in BMD between smokers and nonsmokers at any site. For both smokers and nonsmokers, SHBG and the free androgen index (T/SHBG) made significant contributions (P<0.005) to the variance in BMD at all sitesexcept the lumbar spine. The free estradiol index (E2/SHBG) contributed to whole body BMD (P<0.05). For all subjects, there were significant inverse relationships between SHBG and BMD (P<0.002), and positive relationships between T/SHBG and BMD (P<0.02) for all sites except the lumbar spine. These data suggest that moderate smoking in young women is not associated with low BMD at any site. However, smokers had lower free estradiol and higher SHBG, both of which have been related to increased bone loss in older women.

Human body composition: A review of adult dissection data

Although body composition analysis is popular, dissection data are sparse and sometimes difficult to access. Published data that include the weights of skin, adipose tissue, muscle, and bone, along with body weight, are reviewed. The 31 men and 20 women include 34 cadavers from three separate dissection studies in Brussels, 12 from 19th century reports, and 5 from the United States. The age range was 16–94y. Men differed from women in that they had less adipose tissue and more muscle in both absolute and relative terms. The body mass index (BMI) did not differ between the sexes, because lower weights of muscle and bone compensated for the greater adiposity in women. The relationship between the BMI and relative adiposity was significant, but the BMI explained only about one‐third of the variance in adiposity, indicating that in this sample it is a poor predictor of fatness. The composition of the fat‐free weight (FFW) and adipose tissue free weight (ATFW), though less variable than body weight, showed enough variability that the assumption of constancy of the fat‐free body required for densitometry and other indirect methods of fat estimation, could not be supported. In the few dissections that did fat extraction, essential on non‐adipose fat, varied from 4–14% of the FFW, thus undermining the concept of lean body weight. More dissection data are needed, especially in children and adolescents, and especially in conjunction with in vivo body composition methods to help in their validation. Am. J. Hum. Biol. 11:167–174, 1999.

Temporal Relationships of Self-Efficacy and Social Support as Predictors of Adherence in a 6-Month Strength-Training Program for Older Women

The present study investigated how self-efficacy and social support predicted adherence to a strength-training program for elderly women over two time periods in the initial 6 mo. of the program. Participants were 30 elderly women volunteers aged 75 to 80 who completed measures of barrier self-efficacy and general social support at baseline and 3 mo. later. Social support from the program was also measured at 3 mo. Adherence to the program was measured by attendance. Hierarchical regression equations were utilized to identify the contributions of self-efficacy and social support for adherence at 0 to 3 mo. and 4 to 6 mo. For prediction of the first 3 mo. of adherence, both self-efficacy and social support contributed significant unique variance towards the total explained variance of 36%. For the 4- to 6-mo. period, self-efficacy explained significant (12%) variance in adherence even when controlling for the previous 3-mo. adherence. Inclusion of general social support and social support from the program, however, did not account for significant variance. Researchers must continue to examine self-efficacy and social support in exercise adherence within various time periods among older adults to develop effective intervention strategies.

Muscle mass of competitive male athletes

The recent publication of the first validated equation for the estimation of muscle mass (MM) in men has made possible a comparison of MM in athletes from different sports. Limb girths and skinfold thicknesses were measured in 62 male athletes (aged 17-38 years) and 13 non-athletic males (aged 22-36 years). The MM (g) was calculated from the equation MM = S(0.0553 Gt2 + 0.0987 Gf2 + 0.0331 Gc2)-2445, where S is stature, Gt is the mid-thigh girth corrected for the front thigh skinfold thickness, Gc is the maximum calf girth corrected for the calf skinfold thickness and Gf is the uncorrected maximum forearm girth (all in cm). The athletes were classified as gymnasts (n = 10), basketball players (n = 10), body-builders (n = 10), track and field power athletes (n = 12), track and field long sprinters (n = 10) or distance runners (n = 10). The MM means ranged from 38.4 kg for the distance runners to 58.7 kg for the body-builders. Both body-builders and basketball players had significantly greater MM than gymnasts, long sprinters, non-athletic males and distance runners (P < 0.01). Also, MM was greater in track and field power athletes than in distance runners (P < 0.05). The MM as a percentage of body mass (%MM) ranged from 56.5% in the non-athletic group to 65.1% in the body-builders; body-builders scored higher than basketball players (P < 0.05), distance runners (P < 0.01) and the non-athletic group (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Relationships between visceral, trunk and whole-body adipose tissue weights by cadaver dissection.

Background: Despite the important association of central adiposity and cardiovascular and other risk factors, there are only three reported values for directly weighed visceral adipose tissue (AT). All other reported values are based on medical imaging techniques. Objective: The study aimed to investigate the relationships between visceral, trunk and total AT weights in older men and women. Methods: Data was obtained from the combination of two studies involving the complete dissection of 15 male and 16 female cadavers (age range 55–94 years) and allowed for compartmentation into skin, AT, muscle, bone and a residual component, divided over six body segments: head, trunk, legs and arms. Visceral AT was separated from trunk subcutaneous AT. All tissues were weighed. Results: Visceral AT weights ranged from 0.3 to 5.8 kg. Mean values were 3.00 ± 1.52 kg (mean ± SE) for the men and 3.24 ± 1.67 kg for the women. These were not significantly different ( p = 0.68), but visceral AT weight, expressed as a percentage of total body AT weight was significantly greater ( p = 0.02) in the men (16.8 ± 5.4%) than in the women (12.9 ± 3.5%). Correlations between visceral AT weight and the weight of subcutaneous AT of the trunk were highly significant (men, r = 0.70, women, r = 0.81, p < 0.005), with similar slopes for the two sexes. The correlation coefficients of visceral with total body AT weights were even greater (men, r = 0.83 and women, r = 0.96, p < 0.0001). Conclusions: In this sample of older Belgians, visceral AT is strongly related to total body adiposity, corresponding to an increment of about 200 g of visceral AT for every kilogram of total AT in men and about 180 g in women. Because of this relationship, techniques such as skinfold calipers and ultrasound for assessing whole body fatness from measurement of only the subcutaneous layer are thus able to account for visceral adiposity.

Effects of skin thickness and skinfold compressibility on skinfold thickness measurement

Variability in both skin thickness and skinfold compressibility affects the relationship between the skinfold caliper reading at a particular site on the body and the actual adipose thickness at that site, thus inducing error in the estimation of body fatness. To investigate this variability, skinfold thickness by caliper and incised depth of subcutaneous adipose tissue were measured at 13 skinfold sites in 6 male and 7 female unembalmed cadavers aged 55 to 94 years. All skin was then removed and its thickness measured at the exact sites of skinfold measurement. The regional patterns for skin thickness were similar in men and women, though women had significantly (P < .05) thinner skin than men at the biceps, chest, supraspinale, and abdominal sites. Mean (SD) skin thickness for each cadaver over all sites ranged from 0.76 mm (0.28 mm) to 1.47 mm (0.43 mm), with an overall mean for men of 1.22 mm (0.36 mm) and for women of 0.98 mm (0.36 mm). The thickness of a double layer of skin expressed as a percentage of skinfold thickness for all cadavers over all 13 sites ranged from 7.1% to 33.4%. Because of their leanness and thicker skin, the mean for men, 22.7% (10.1%), was significantly greater than that for women, 10.8% (6.2%) (P < .0001). Mean skinfold compressibility over all sites was 53.5% (16.4%) in men adn 51.9% (16.5%) in women (not significant). Such marked variability in skinfold compressibility and in the relative contribution of skin thickness to skinfold thickness suggests the need for caution in comparing estimates of fatness by skinfold caliper between different subjects.