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Alan Rein

Johns Hopkins University School of Medicine

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Featured researches published by Alan Rein.

Archive | 1991

Roles of Nucleocapsid Cysteine Arrays in Retroviral Assembly and Replication: Possible Mechanisms in RNA Encapsidation

Robert J. Gorelick; Stephen M. Nigida; Larry O. Arthur; Louis E. Henderson; Alan Rein

The nucleocapsid (NC) proteins of all retroviruses contain either one or two copies of a sequence motif, C-X2-C-X4-H-X4-C, which has been termed the “cysteine array” or Cys-His box. Studies from several laboratories have shown that mutants in this motif direct the production of virus particles; these particles are structurally normal in many respects, but are either partially or completely deficient in genomic RNA. Further, even when some RNA is encapsidated, the particles are almost completely noninfectious.

Proceedings of the National Academy of Sciences of the United States of America | 1988

Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence

Robert J. Gorelick; Louis E. Henderson; J P Hanser; Alan Rein

Proceedings of the National Academy of Sciences of the United States of America | 1998

Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: Implications for retroviral assembly mechanisms

Mark Yeager; Elizabeth M. Wilson-Kubalek; Scott G. Weiner; Patrick O. Brown; Alan Rein

Proceedings of the National Academy of Sciences of the United States of America | 1996

HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro

Ya-Xiong Feng; Terry D. Copeland; Louis E. Henderson; Robert J. Gorelick; W J Bosche; Judith G. Levin; Alan Rein

Proceedings of the National Academy of Sciences of the United States of America | 1988

Point Mutants of Moloney Murine Leukemia Virus that Fail to Package Viral RNA: Evidence for Specific RNA Recognition by a

Robert J. Gorelick; Louis E. Henderson; Janet P. Hanser; Alan Rein

Proceedings of the National Academy of Sciences of the United States of America | 1995

Targeting of a nuclease to murine leukemia virus capsids inhibits viral multiplication.

Georges Natsoulis; Partha Seshaiah; Mark J. Federspiel; Alan Rein; Stephen H. Hughes; Jef D. Boeke

Proceedings of the National Academy of Sciences of the United States of America | 1981

Baboon endogenous virus genome: molecular cloning and structural characterization of nondefective viral genomes from DNA of a baboon cell strain

Maurice Cohen; Alan Rein; Robert M. Stephens; Catherine O'Connell; Raymond V. Gilden; Mavis Shure; Margery O. Nicolson; Robert M. McAllister; Norman Davidson

Archive | 2001

Cell-free assembly of lentiviral capsids

Stephen Campbell; Alan Rein; Eric M. Towler; Robert J. Fisher; Haleem J. Issaq

Archive | 2003

Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid

Robert H. Shoemaker; Michael J. Currens; Alan Rein; Ya-Xiong Feng; Robert J. Fisher; Andrew G. Stephen; Karen M. Worthy; Shizuko Sei; Bruce J. Crise; Louis E. Henderson

Archive | 1998

Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: Implications for retroviral assembly mechanisms (image processingyretrovirusesyvirus assembly)

Mark Yeager; E Lizabeth M. Wilson-Kubalek; Scott G. Weiner; Patrick O. Brown; Alan Rein

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Louis E. Henderson

University of Pennsylvania

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Robert J. Fisher

Science Applications International Corporation

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Robert J. Gorelick

Leidos

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Jose R. Casas-Finet

University of California

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Matthew J. Fivash

National Institutes of Health

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Larry O. Arthur

University of Pennsylvania

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Mark Yeager

University of Virginia

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Patrick O. Brown

Stanford University

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Scott G. Weiner

Brigham and Women's Hospital

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Ya-Xiong Feng

National Institutes of Health

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