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Journal of Pharmacological and Toxicological Methods | 2006

ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

Laurie A. Hanson; Alan S. Bass; Gary A. Gintant; Scott W. Mittelstadt; David Rampe; Karluss Thomas


Journal of Pharmacological and Toxicological Methods | 2004

Origins, practices and future of safety pharmacology

Alan S. Bass; Lewis B. Kinter; Patricia Williams


Journal of Pharmacological and Toxicological Methods | 2005

Non-clinical evaluation of ventricular repolarization (ICH S7B) : Results of an interim survey of international pharmaceutical companies

Gregory S. Friedrichs; Leslie Patmore; Alan S. Bass


Journal of Pharmacological and Toxicological Methods | 2005

Drugs effects on ventricular repolarization: A critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices

Alan S. Bass; Gordon Tomaselli; Roy Bullingham; Lewis B. Kinter


Journal of Pharmacological and Toxicological Methods | 2004

New preclinical guidelines on drug effects on ventricular repolarization: safety pharmacology comes of age.

Lewis B. Kinter; Peter K.S. Siegl; Alan S. Bass


Journal of Pharmacological and Toxicological Methods | 2007

ILSI-HESI cardiovascular safety subcommittee dataset: an analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc).

Alan Y. Chiang; Alan S. Bass; Murray M. Cooper; Michael Engwall; Ronald G. Menton; Karluss Thomas


Journal of Pharmacological and Toxicological Methods | 2005

Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A.

Jean-Pierre Valentin; Alan S. Bass; Aisar Atrakchi; Klaus Olejniczak; Fujimori Kannosuke


Journal of Pharmacological and Toxicological Methods | 2004

Introduction to nonclinical safety pharmacology and the safety pharmacology society.

Alan S. Bass; Hugo M. Vargas; Lewis B. Kinter


Journal of Pharmacological and Toxicological Methods | 2005

Validation of a motor activity system by a robotically controlled vehicle and using standard reference compounds.

John P. Patterson; Carrie Markgraf; Maria Cirino; Alan S. Bass


Journal of Pharmacological and Toxicological Methods | 2007

Points to consider emerging from a mini-workshop on cardiac safety: Assessing torsades de pointes liability

Alan S. Bass; Jean-Pierre Valentin; Anthony A. Fossa; Paul G.A. Volders

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