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Dive into the research topics where Albert John Molinari is active.

Publication


Featured researches published by Albert John Molinari.


Bioorganic & Medicinal Chemistry Letters | 2000

The design, synthesis and physical chemical properties of novel human vasopressin V2-receptor antagonists optimized for parenteral delivery.

Mark A. Ashwell; Jehan Framroz Bagli; Thomas Joseph Caggiano; Peter S. Chan; Albert John Molinari; C Palka; C.H. Park; J.F Rogers; Mary M. Sherman; Eugene J. Trybulski; David K. Williams

Ionizable groups were introduced onto the 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine scaffold of the vasopressin V2-antagonist WAY-VPA-985 in the search for molecules optimized for parenteral formulation. The synthesis and structure activity relationships (SAR) are presented together with solubility data in a model parenteral system. The amine, WAY-140288 (4f), was chosen for further development. p6


Archive | 2001

Heterocyclic Beta-3 adrenergic receptor agonists

Mark A. Ashwell; William Ronald Solvibile; Dominick Anthony Quagliato; Albert John Molinari


Archive | 1997

3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines

Eugene John Trybulski; Albert John Molinari; Jehan Framroz Bagli; Mark A. Ashwell; Thomas Joseph Caggiano


Archive | 2006

Diarylsulfone sulfonamides and use therof

Ariamala Gopalsamy; William Jay Moore; Jeffery Curtis Kern; Albert John Molinari; Mengxiao Shi; Gregory S. Welmaker; Matthew A. Wilson; Girija Krishnamurthy; Thomas Joseph Commons; Michael Byron Webb; Richard Page Woodworth


Archive | 2003

Substituted dihydrophenanthridinesul fonamides

Albert John Molinari; Mark A. Ashwell; Brian Hugh Ridgway; Amedeco Arturo Failli; William Jay Moore


Archive | 2002

Biologically active vasopressin agonist metabolites

Albert John Molinari; Eugene John Trybulski


Bioorganic & Medicinal Chemistry Letters | 2007

Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan.

Albert John Molinari; Eugene John Trybulski; Jehan Framroz Bagli; Susan Christman Croce; John Considine; Jian Qi; Kadum Ali; William DeMaio; Lynne Lihotz; David Cochran


Archive | 2001

Heterocyclic β-3 adrenergic receptor agonists

Mark A. Ashwell; William Ronald Solvibile; Dominick Anthony Quagliato; Albert John Molinari


Archive | 2005

Phenanthridine carbonyl phenols as cytokine modulators

Robert J. Steffan; William Jay Moore; Eugene John Trybulski; Albert John Molinari


Archive | 2003

Pyrrolo'2,1-c!'1,4! benzodiazepines as vasopressin agonists

Albert John Molinari; Eugene John Trybulski

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Gregory S. Welmaker

Torrey Pines Institute for Molecular Studies

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