Aldo A. Garza

Primary biliary cholangitis associated with warm autoimmune hemolytic anemia.

There are many autoimmune diseases associated with primary biliary cholangitis (PBC), known as primary biliary cirrhosis; however, the association between PBC and warm autoimmune hemolytic anemia (wAIHA) has rarely been reported. It is documented that hemolysis is present in over 50% of the patients with chronic liver disease, regardless of the etiologies. Due to the clear and frequent relationship between PBC and many autoimmune diseases, it is reasonable to suppose that wAIHA may be another autoimmune disorder seen in association with PBC. Here we reported a 53‐year‐old female patient diagnosed with wAIHA associated with PBC.

Primary biliary cirrhosis associated with warm‐type autoimmune hemolytic anemia

There are many autoimmune diseases associated with primary biliary cholangitis (PBC), known as primary biliary cirrhosis; however, the association between PBC and warm autoimmune hemolytic anemia (wAIHA) has rarely been reported. It is documented that hemolysis is present in over 50% of the patients with chronic liver disease, regardless of the etiologies. Due to the clear and frequent relationship between PBC and many autoimmune diseases, it is reasonable to suppose that wAIHA may be another autoimmune disorder seen in association with PBC. Here we reported a 53‐year‐old female patient diagnosed with wAIHA associated with PBC.

T1950 Use of Proton Pump Inhibitors On Admission Is a Protective Factor for Three Day-Mortality in Non-Variceal Bleeding (NVB)

ever, compared to patients undergoing delayed endoscopy, those with early endoscopy had a lower initial blood pressure (p=0.06), lower platelet count (p=0.008), higher transfusion requirement (p=0.04), and were more likely to be managed in the ICU (p<0.0001) and have varices (p=0.009). That is, patients undergoing early endoscopy had more severe illness vs. those receiving delayed endoscopy. In logistic regression adjusting for these and other confounders, performance of early endoscopy was associated with an 85% reduction in mortality (OR=0.15; CI=0.04-0.71).Conclusion: Performance of early endoscopy is a surrogate marker for bleeding severity. When adjusting for systematic differences between patients receiving early vs. delayed endoscopy, performance of early endoscopy in this cohort was associated with a striking reduction in mortality. These data provide additional support to the argument that early endoscopy should be standard of care in acute GI hemorrhage.

T1949 Clinical Features and Risk Factors for Three-Day Mortality in Elderly Patients with Non Variceal Bleeding

ever, compared to patients undergoing delayed endoscopy, those with early endoscopy had a lower initial blood pressure (p=0.06), lower platelet count (p=0.008), higher transfusion requirement (p=0.04), and were more likely to be managed in the ICU (p<0.0001) and have varices (p=0.009). That is, patients undergoing early endoscopy had more severe illness vs. those receiving delayed endoscopy. In logistic regression adjusting for these and other confounders, performance of early endoscopy was associated with an 85% reduction in mortality (OR=0.15; CI=0.04-0.71).Conclusion: Performance of early endoscopy is a surrogate marker for bleeding severity. When adjusting for systematic differences between patients receiving early vs. delayed endoscopy, performance of early endoscopy in this cohort was associated with a striking reduction in mortality. These data provide additional support to the argument that early endoscopy should be standard of care in acute GI hemorrhage.