Alejandro Martin-Gorgojo

Psoriasis lesions are associated with specific types of emotions. Emotional profile in psoriasis

BackgroundAt present there is still controversy about the relationship between emotional stress and psoriasis lesions. Most of the published literature does not include the broad spectrum of emotional response.ObjectiveThe aim of this study was to evaluate the association between skin lesions and emotional state in a large sample of patients with psoriasis.Methods823 psoriasis patients were recruited (mean age 45.9 years, 55.7% female) and answered two online questionnaires: lesion severity and current extension were evaluated using a self-administered psoriasis severity index (SAPASI); emotional state was assessed using the positive and negative affect schedule (PANAS). Second order factors were calculated and correlated with the SAPASI.ResultsWe found positive associations between the extent and severity of skin lesions and the negative and submissive emotions, a negative correlation with dominance emotions and no association with positive emotions.ConclusionsOur data supports the relationship between emotions and skin lesions. It also allows for discrimination of the associations between psoriasis lesions and the specific type of emotions.

Is methylisothiazolinone contact allergy a risk factor for polysensitization

Keywords: methylchloroisothiazolinone; contact allergy; contact dermatitis; cosmetics; methylisothiazolinone; occupational diseases; patch test; preservatives

Chronic graft-versus-host disease presenting with coexisting diffuse melanoderma and hypopigmented patches: A peculiar presentation

A 52-year-old Caucasian woman came to our department for evaluation. Her past medical history included the diagnosis, seven years before, of breast cancer, which was treated with surgery and multiple chemotherapy regimes, and, three years later, of a stage IIIA large-cell follicular lymphoma, which required up to four lines of chemotherapy and local radiotherapy on the main tumor mass to achieve a partial response. Allogeneic hematopoietic progenitor cell transplantation from an HLA-identical unrelated [...]

Histiocytosis with mixed cell populations.

Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10‐year‐old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.

Differential diagnosis in neutrophilic lobular panniculitis

In this edition of DeRmpath & Clinic, we present the case of a 65-year-old patient, with a past medical history of chronic pancreatitis requiring enzyme supplementation, who developed several non-painful erythematous subcutaneous nodules located on her right upper limb, two weeks after intraabdominal surgery for acute intestinal obstruction. No local trauma was experienced. No fever, arthralgia, or any other symptoms were reported previously. Histopathological examination revealed the following [...]

Residents’corner March-April 2016. Editorial: What’s new this month?

Immunotherapy for melanoma patients is a promising treatment option, as clinical evidence of the use of systemic CTLA4- and PD1-antibodies has demonstrated. With the exception of unresectable melanoma patients, there is a great need for an adequate therapeutic option for patients with locally advanced melanoma (stage III). In this issue of the European Journal of Dermatology, Seledtsova et al.[1] report their investigations on the treatment of stage III melanoma patients with a xenogeneic cell-based [...]

Residents'corner January/February 2016. Editorial: What's new this month?

Biological agents (BAs) have been prescribed for inflammatory dermatoses for the past two decades. The most frequent side effects (infections) are now very well documented, but rare side effects are sometimes difficult to characterise. Clinical reports of monoclonal gammopathy of undetermined significance (MGUS) while being treated with a BA (notably TNFα-inhibitors) have been reported [1], however, the involvement of BAs continues to be a matter of debate [2]. In this issue of the European Journal [...]

Editorial: What's new this month?

1 Dermatology Department. General University Hospital Gregorio Marañon. C/ Doctor Esquerdo 46, 28007 Madrid, Spain. Dermatology Department. Clinica Dermatologica Internacional and Clinica Ruber. Madrid, Spain e-mail: alejandromartingorgojo@aedv.es 2 Dermatology Department, Hôpital Edouard Herriot, Lyon, France e-mail: axel.villani@gmail.com 3 Dermatology Department. Hospital de Santo António dos Capuchos Centro Hospitalar de Lisboa Central. Alameda Santo António dos Capuchos 1169-050, Lisbon, Portugal e-mail: joanacabete@gmail.com 4 Dermatology department, Box 46, Addenbrooke’s Hospital, Hills road, Cambridge, CB2 0QQ, UK e-mail: alanadurack@yahoo.com 5 Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, Av. de Beaumont 29, CH-1011 Lausanne, Switzerland e-mail: Francois.Kuonen@chuv.ch 6 Department of Dermatology, Venerology and Allergology, University Hospital Wuerzburg, Joseph-Schneider-Str. 2, 97080 Wuerzburg, Germany e-mail: Behle_V@ukw.de

Residents’ corner July-August 2016 Editorial: What’s new this month?

1 Dermatology Department, Hospital de Santo António dos Capuchos Centro Hospitalar de Lisboa Central, Alameda Santo António dos Capuchos 1169-050, Lisbon, Portugal e-mail: joanacabete@gmail.com 2 Dermatology Department, Hôpital Edouard Herriot, Lyon, France e-mail: axel.villani@gmail.com 3 Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, Av. de Beaumont 29, CH-1011 Lausanne, Switzerland e-mail: Francois.Kuonen@chuv.ch 4 Dermatology department, Box 46, Addenbrooke’s Hospital, Hills road, Cambridge, CB2 0QQ, UK e-mail: alanadurack@yahoo.com 5 Department of Dermatology, Venerology and Allergology, University Hospital Wuerzburg, Joseph-Schneider-Str. 2, 97080 Wuerzburg, Germany e-mail: Behle_V@ukw.de 6 Dermatology Department, General University Hospital Gregorio Marañon C/ Doctor Esquerdo 46; Dermatology Department, Clinica Dermatologica Internacional and Clinica Ruber, Madrid, Spain e-mail: alejandromartingorgojo@aedv.es

Residents’ corner May-June 2016. Editorial: What’s new this month?

1 Dermatology Department, Box 46, Addenbrooke’s Hospital, Hills road, Cambridge, CB2 0QQ, UK e-mail: alanadurack@yahoo.com 2 Dermatology Department, Hospital de Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Alameda Santo António dos Capuchos 1169-050, Lisbon, Portugal e-mail: joanacabete@gmail.com 3 Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany e-mail: Behle_V@ukw.de 4 Dermatology Department, Hôpital Edouard Herriot, Lyon, France e-mail: axel.villani@gmail.com 5 Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, Av. de Beaumont 29, CH-1011 Lausanne, Switzerland e-mail: Francois.Kuonen@chuv.ch 6 Dermatology Department, General University Hospital “Gregorio Marañon”, C/ Doctor Esquerdo 46, 28007 Madrid, Spain and Dermatology Department, Clinica Dermatologica Internacional and Clinica Ruber, Madrid, Spain e-mail: alejandromartingorgojo@aedv.es