Alejandro Palma Castro

A SHORT SYNTHESIS OF INDOLIZIDINE (+)-209B FROM (3R,6S,8aS)-(-)-6-METHYL-3-PHENYLHEXAHYDROOXAZOLO[3,2-a]-PYRIDIN-5-ONE

The synthetic potential of enantiopure (3R,6S,8aS)-(-)-6-methyl-3-phenylhexahydrooxazolo[3,2-a]pyridin-5-one 2 is illustrated by a short synthesis of the 5,8-disubstituted indolizidine alkaloid (+)-209B.

Diastereoselective Approach to cis-4-Methyl/thiol-Pipecolic Esters Based on RCM Reaction and Conjugate Michael Addition

Abstract A synthetic route for the access to enantiopure cis-4-methyl/thiol-pipecolic esters is presented. It is based on the ring-closing metathesis reaction to build the α,β-unsaturated piperidin-2-one derived from (S)-(–)-phenylethylamine, followed by either diastereoselective conjugate addition of methylorganocuprate allowing access to cis-4-methyl pipecolic ester or by tandem diastereoselective hydrosulforization–thionization reaction providing access to cis-4-thiol pipecolic ethyl esters. GRAPHICAL ABSTRACT

Regioselective Endocyclic Oxidation of Enantiopure 3‐Alkylpiperidines: Synthesis of (3S,5S)‐(‐)‐3‐Ethyl‐5‐Methylpiperidine

Abstract An efficient regioselective endocyclic oxidation of enantiopure 3‐alkylpiperidines 1(a–c) with bromine in acetic acid to generate the corresponding 5‐alkylpiperidin‐2‐ones 3(a–c) as main product is described. In addition, starting from 3a or 3b, the synthesis of (3S,5S)‐(‐)‐3‐ethyl‐5‐methylpiperidine 6 · HCl was achieved. Finally, the X‐ray single‐crystal analysis of compound 4 is reported.

Topoiesis: Procesos de espacialización en la literatura (crítica y metodología)

ABSTRACTSpace in literary texts has been widely studied but poorly systematized. There is no valid method of analysis that gives space a critical meaning. For instance, critics have eluded the fact that time and space cannot be considered separately. On the other hand, they have used concepts or methods from disciplines aside literature such as anthropology, biology, psychology, or geography that do not help clarify the meaning or signification of a literary text. We begin this article by giving a review of the main theoretical and critical positions regarding space in literature from the second half of the twentieth century. We do this in order to evaluate the main results those studies have attained. Later on, we propose a methodology that may clarify the significance of space in a literary text. The concept topoiesis (as far as we know, it has not been used in the humanities) represents for us a key word. It helps us to distinguish one main process where space can turn from a signification practice to ...ABSTRACT Space in literary texts has been widely studied but poorly systematized. There is no valid method of analysis that gives space a critical meaning. For instance, critics have eluded the fact that time and space cannot be considered separately. On the other hand, they have used concepts or methods from disciplines aside literature such as anthropology, biology, psychology, or geography that do not help clarify the meaning or signification of a literary text. We begin this article by giving a review of the main theoretical and critical positions regarding space in literature from the second half of the twentieth century. We do this in order to evaluate the main results those studies have attained. Later on, we propose a methodology that may clarify the significance of space in a literary text. The concept topoiesis (as far as we know, it has not been used in the humanities) represents for us a key word. It helps us to distinguish one main process where space can turn from a signification practice to the production of meaning in a literary text.

Topoiesis de la recepción literaria

ABSTRACT This article proposes a particular notion about “topoiesis,” focusing on the text reception point of view. Initially, it establishes a theoretical framework using useful concepts from hermeneutics and post-structuralism, to later discuss the real existence of a dialogue or a “fusion of horizons” in which a “sense of space” of a text would be blended in the meeting point between textuality and the reader. Finally, through this space we propose a categorization of the different types of “topoiesis” of literary reception, establishing correspondences with the concept of “enunciative instances” in the text space, detailed in another article.ABSTRACTThis article proposes a particular notion about “topoiesis,” focusing on the text reception point of view. Initially, it establishes a theoretical framework using useful concepts from hermeneutics and post-structuralism, to later discuss the real existence of a dialogue or a “fusion of horizons” in which a “sense of space” of a text would be blended in the meeting point between textuality and the reader. Finally, through this space we propose a categorization of the different types of “topoiesis” of literary reception, establishing correspondences with the concept of “enunciative instances” in the text space, detailed in another article.

Topoiesis de las instancias enunciativas

ABSTRACT The literary text is a communicative situation that involves a sender, a message, and a receiver. Literary theorists and critics have extensively studied the different instances of enunciation, making it clear that the author of a literary text is not the enunciator of it. This article intends to show that each one of them belongs to a distinctive level: those of the communicative situation and the enunciative situation. This article intends to show the space-time axis related to the situations mentioned above. This would allow the researcher to find the mechanisms of power that lie behind the authorization or discredit of a speech. By doing so, we intend to extend the analysis of the literary work, including the context of creation of the literary text. We would like to focus our attention on three aspects related to the enunciator: topoiesis of the communicative situation, topoiesis of the enunciative frame, and topoiesis of the writing individual.ABSTRACTThe literary text is a communicative situation that involves a sender, a message, and a receiver. Literary theorists and critics have extensively studied the different instances of enunciation, making it clear that the author of a literary text is not the enunciator of it. This article intends to show that each one of them belongs to a distinctive level: those of the communicative situation and the enunciative situation. This article intends to show the space-time axis related to the situations mentioned above. This would allow the researcher to find the mechanisms of power that lie behind the authorization or discredit of a speech. By doing so, we intend to extend the analysis of the literary work, including the context of creation of the literary text. We would like to focus our attention on three aspects related to the enunciator: topoiesis of the communicative situation, topoiesis of the enunciative frame, and topoiesis of the writing individual.

Topoiesis del espacio textual

ABSTRACT The concept of topoiesis of textual space addresses an analysis of the spatial elements that tend to provide a meaning to the literary text. Based on textual semiotics where there is an organized relational system of meanings, in this article we propose that it is possible to determine the function of space as a meaning issue from three different literary text instances (event or motive; character; and object). This distinction will permit a deeper interpretation of the sense of space in the literary text.ABSTRACTThe concept of topoiesis of textual space addresses an analysis of the spatial elements that tend to provide a meaning to the literary text. Based on textual semiotics where there is an organized relational system of meanings, in this article we propose that it is possible to determine the function of space as a meaning issue from three different literary text instances (event or motive; character; and object). This distinction will permit a deeper interpretation of the sense of space in the literary text.

Topoiesis de los dispositivos de registro del texto literario

ABSTRACT Never before have the layout, the text format, and support been as important as they are today. Studies reflecting on the relationship between the meaning of the literary text and its form have rapidly increased. This kind of study has focused mostly on the history of the reading process and the history of the book as well as on the possibilities of new technologies in the literary field. However, none of these approaches has reached the point of creating a comprehensive methodology for the analysis of the relationship between the message and its channel. This work is intended to propose a methodology of analysis based on some concepts such as peritexts (Genette) and visuo-graphic zone (Cárdenas).