Aleksandar Trivic

Oncological and Functional Outcome after Surgical Treatment of Early Glottic Carcinoma without Anterior Commissure Involvement

Introduction. Glottic carcinoma can be successfully diagnosed in its early stages and treated with high percentage of success. Organ preservation and optimal functional outcomes could be achieved with wide array of surgical techniques for early glottic cancer, including endoscopic approaches or open laryngeal preserving procedures, making surgery the preferred method of treatment of early glottic carcinoma in the last few years. Material and Methods. Prospective study was done on 59 patients treated for Tis and T1a glottic carcinoma over a one-year time period in a tertiary medical center. Patients were treated with endoscopic laser cordectomy (types II–IV cordectomies according to European Laryngological Society classification of endoscopic cordectomies) and open cordectomy through laryngofissure. Follow-up period was 60 months. Clinical and oncological results were followed postoperatively. Voice quality after the treatment was assessed using multidimensional voice analysis 12 months after the treatment. Results. There were no significant differences between oncological and functional results among two groups of patients, though complications were more frequent in patients treated with open cordectomy. Conclusion. Endoscopic laser surgery should be the first treatment of choice in treatment of early glottic carcinomas, though open approach through laryngofissure should be available for selected cases where anatomical factors present limiting adequate tumor removal.

Evaluation of local and regional spread of malignant tumors of the tongue and floor of the mouth

Malignant tumors of the oral cavity grow rapidly, frequently and early metastazing to the surrounding regional lymph nodes. The aim of this study was to evaluate the correlation between clinically confirmed local and regional spread and intraoperatively and histopathologically verified local spread. A series of 74 patients with carcinoma of the tongue and floor of the mouth were analyzed. All the patients were surgically treated during the period 1991-1995. Clinical evidence of local spread (cT) was in high accord with intraoperatively and histopathologically evidenced spread (pT) amounting to 83.8%. The degree of correlation decreased with the increase of T stage. Clinically observed regional spread (cN) and intraoperatively and histopathologically confirmed regional spread (pN) was lower, amounting to 56.8% in comparison to the corresponding T categories.

European Organization for Research and Treatment of Cancer Quality of Life Questionnaire–Head and Neck Module, updated version: Preliminary psychometric data from Serbian laryngectomized patients

We provided preliminary psychometric data for the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire–Head and Neck Module, updated version (QLQ‐H&N43) from a group of Serbian laryngectomized patients.

Laryngeal Granuloma – Benefit in Treatment with Zinc Supplementation? / Larinksni Granulom - Korist Od Terapije Preparatima Cinka

Summary Laryngeal granulomas present as contact and postintubation ulcers and granulomas. Essentially, a contact granuloma is a pseudotumor of the lateral wall of the posterior glottis. The most common etiological factor is voice abuse, with predisponing factors such as reflux disease. Postintubation ulcers and granulomas, although of different etiology, according to all the other traits belong to this clinical entity. The therapy of choice is conservative treatment. Surgical laser excision is indicated for resistant cases and those whose size is causing respiratory distress. Treatment of laryngeal granulomas with zinc supplementation is reported in the literature as one of the forms of conservative treatment, and we wanted to consider it in this review. Zinc is an essential mineral that plays a vital role in many biochemical reactions and is considered very important for wound healing. Kratak sadržaj Larinksni granulom se predstavlja kon- taktnim i postintubacionim ulkusom i granulomom. U suštini, kontaktni granulom je pseudotumorski izraštaj late- ralnog zida zadnjeg dela glotisa. Najčešći etiološki faktor je neodgovarajuća upotreba glasa, uz predisponirajuće faktore kao što je refluksna bolest. Postintubacioni ulkus i granulom, iako drugačije etiologije, po svim ostalim osobinama pri- padaju ovom kliničkom entitetu. Preporučena terapija je konzervativno lečenje, a hirurška laserska ekscizija indiko- vana je za rezistentne slučajeve i one koji svojom veličinom izazivaju respiratorne smetnje. U literaturi se pominje per- oralna primena preparata cinka u terapiji larinksnog granulo- ma kao jedan od vidova konzervativnog lečenja, što smo i mi u ovom kratkom pregledu želeli da razmotrimo. Cink je esen- cijalni mineral koji igra ključnu ulogu u mnogim biohemij- skim reakcijama i smatra se da je veoma važan za zarastanje rana.