Aleksandr V. Kutchin

Synthesis and membrane-protective activity of novel derivatives of α-mangostin at the C-4 position.

A series of new C-4-derivatives of α-mangostin has been synthesized with the use of Mannich reaction and alkylation with 4-bromomethyl-2,6-dialkylphenols. It has been shown on a model of H2O2-induced erythrocyte hemolysis that the Mannich bases containing morpholinomethyl and piperidinomethyl fragments differ from parent α-mangostin by their high antioxidant and membrane-protective activity.

Convenient Synthesis of 2,2′- and 4,4′-Methylenebisphenols with Bulky Alkyl Substituents and Evaluation of Their Antioxidant Activity

Abstract The work is devoted to a convenient procedure of the synthesis of 2,2′- and 4,4′-methylenebisphenols with alkyl substituents in heterogeneous catalysis. This compounds were obtained with yields up to 87% by reflux of 2,4- or 2,6-dialkylphenols with HCHO in n-octane in the presence of KSF clay. We found that the antioxidant activity on DPPH test for two novel methylenebisphenols having isobornyl fragments was comparable with control drugs. GRAPHICAL ABSTRACT

Simple Resolution of Racemic Salicylic Aldehydes Having an Isobornyl Substituent

Abstract The resolution of the racemic salicylic aldehydes with isobornyl fragment 2 via diastereomer formation with (R)-1-phenylethylamine has been carried out.

Caryophyllane thiols, vinyl thioethers, di- and bis-sulfides: antioxidant and membrane protective activities

Caryophyllane thioterpenoids were synthesized in 23 – 81% yields. The antioxidant properties of the obtained compounds in various model systems were found. It was revealed that 4,5‐epoxycaryophyll‐9‐ylmethanethiol has the greatest antioxidant activity. The isomerism of sesquiterpenic fragments was shown to have a significant effect on the biological activity of the compounds.