Alenka Paquet

Reactivity of the Thallium(I) Salts of 3-Hydroxy-1,3,5(10)-estratrien-17-one and 1,3,5(10)-Estratriene-3,17β-diol. Preparation of 17-Oxoestra-1,3,5(10)-trien-3-yl 2′-Acetamido-3′,4′,6′-tri-O-acebtyl-2′-deoxy-β-D-glucopyranoside

Thallium(I) salts of estrone and 17β-estradiol were prepared in high yields by the reaction of estrone or 17β-estradiol with thallium(I) ethoxide. Both compounds were found to be reactive intermediates for alkylation and acylation of the steroid. The preparation and characterization of 17-oxoestra-1,3,5(10)-trien-3-yl 2′-acetamido-2′-deoxy-β-D-glucopyranoside by reaction of the thallium(I) salt of estrone with 2-trifluoroacetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl bromide is described.

REACTIVITY OF THE THALLIUM(I) SALTS OF 3‐HYDROXY‐1,3,5(10)‐ESTRATRIEN‐17‐ONE AND 1,3,5(10)‐ESTRATRIENE‐3,17BETA‐DIOL, PREPARATION OF 17‐OXOESTRA‐1,3,5(10)‐TRIEN‐3‐YL 2′‐ACETAMIDO‐3′,4′,6′‐TRI‐O‐ACETYL‐2′‐DEOXY‐BETA‐D‐GLUCOPYRANOSIDE

Thallium(I) salts of estrone and 17β-estradiol were prepared in high yields by the reaction of estrone or 17β-estradiol with thallium(I) ethoxide. Both compounds were found to be reactive intermediates for alkylation and acylation of the steroid. The preparation and characterization of 17-oxoestra-1,3,5(10)-trien-3-yl 2′-acetamido-2′-deoxy-β-D-glucopyranoside by reaction of the thallium(I) salt of estrone with 2-trifluoroacetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl bromide is described.