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American Journal of Industrial Medicine | 1997

Pleural plaques as risk indicators for malignant pleural mesothelioma: A necropsy-based study

Claudio Bianchi; Alessandro Brollo; Lucia Ramani; Clara Zuch

Pleural plaque is recognized as a reliable marker of previous exposure to asbestos. However, it is controversial whether pleural plaque is a risk indicator for asbestos-related malignancies. In the present study, the thoracic cavities were examined for pleural plaques in 3,005 necropsies performed at the Monfalcone Hospital in people aged 15 years or older. Plaques were classified into three classes: 1, small (plaques measuring 1-4 cm in major diameter); 3, large (plaques involving a major part of a hemithorax); and 2, moderate (intermediate conditions). The prevalences of pleural plaques were 70.9% among men, and 24.0% among women. The prevalences of plaques (total plaques, various classes) among subjects with pleural mesothelioma were compared with those observed in the remaining cases. The series included 92 subjects with malignant pleural mesothelioma (82 men and 10 women). Mesothelioma cases showed higher prevalences of total plaques as well as higher prevalences of classes 1, 2, and 3, when compared with controls. These differences reached the statistical significance for total plaques, and classes 2, 3. The present data are consistent with the idea that pleural plaque is a risk indicator for pleural mesothelioma.


Tumori | 1981

Asbestos Exposure in the Monfalcone Area. A Social and Pathological Study of 100 Autopsy Cases

Claudio Bianchi; Alessandro Brollo; Corradina Miniussi; Lucia Bittesini

Monfalcone is a coastal town with important shipyards. In the present investigation hyalin pleural plaques, lung asbestos bodies, and occupational history were studied in 100 consecutive autopsy cases, collected at the hospital of Monfalcone. Pleural plaques were observed in 72 % of males and in 33 % of females. Asbestos bodies were found after chemical digestion of pulmonary tissue in 94 cases, and an approximate estimation of their amount showed high or very high numbers in 39 cases. Occupational history, obtained from patients’ relatives, was suggestive of occupational asbestos exposure in 60 cases, with 37 subjects having worked in the shipyards. Thirteen other patients had had a probable domestic exposure to asbestos. The severity of asbestos exposure in the Monfalcone area is emphasized.


Tumori | 2018

On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997–2016)

Pietro Gino Barbieri; Dario Mirabelli; Corrado Magnani; Alessandro Brollo

Background: Malignant pleural mesothelioma (MPM) diagnosis is known to be difficult. We report on the diagnostic elements available in life in an MPM necropsy case series and describe the frequency of non-neoplastic asbestos-related diseases as biological exposure indices. Methods: We reviewed pathologic and clinical records of an unselected series of autopsies (1977–2016) in patients with MPM employed in the Monfalcone shipyards or living with shipyard workers. We assessed the consistency with autopsy results of diagnoses based on, respectively, radiologic, cytologic, and histologic findings, with and without immunophenotyping. Results: Data on 171 cases were available: for 169, autopsy confirmed the MPM diagnosis. In life, 119 cases had histologic confirmation of diagnosis, whereas 7 were negative; all cases without immunophenotypization were autoptic MPMs. Cytology alone had been positive in 18 autoptic MPM cases, negative in 14. Radiologic imaging alone had been positive in another 16, negative in 11. In the 2 cases not confirmed at autopsy, MPM had been suspected by chest computed tomography only. Bilateral pleural plaques were found in 144 and histologic evidence of asbestosis in 62 cases. Conclusions: Autopsies confirmed 169/171 cases, including cases that would not be considered as certain based on diagnosis in life. Radiologic imaging, cytologic examination of pleural effusions, or both combined had low sensitivity but high positive predictive value: when they are positive, proceeding to thoracoscopy should be justified. MPM has been correctly diagnosed even without immunohistochemistry. The prevalence of pleural plaques and asbestosis was high due to severity of asbestos exposures in these cases.


The American review of respiratory disease | 1990

Asbestos content of lung tissue, lymph nodes, and pleural plaques from former shipyard workers.

Ronald F. Dodson; Marion G. Williams; Carolyn J. Corn; Alessandro Brollo; Claudio Bianchi


Annals of the New York Academy of Sciences | 1991

A Comparison of Asbestos Burden in Lung Parenchyma, Lymph Nodes, and Plaques

Ronald F. Dodson; Marion G. Williams; Carolyn J. Corn; Alessandro Brollo; Claudio Bianchi


Industrial Health | 2001

Asbestos Exposure in Malignant Mesothelioma of the Pleura: A Survey of 557 Cases

Claudio Bianchi; Alessandro Brollo; Lucia Ramani; Tommaso Bianchi; Luigi Giarelli


American Journal of Industrial Medicine | 1993

Asbestos-related mesothelioma in monfalcone, Italy

Claudio Bianchi; Alessandro Brollo; Lucia Ramani; Clara Zuch


Industrial Health | 2004

Familial mesothelioma of the pleura--a report of 40 cases.

Claudio Bianchi; Alessandro Brollo; Lucia Ramani; Tommaso Bianchi; Luigi Giarelli


Industrial Health | 2000

Asbestos Exposure in a Shipyard Area, Northeastern Italy

Claudio Bianchi; Alessandro Brollo; Lucia Ramani


American Journal of Industrial Medicine | 1999

Asbestos exposure in lung carcinoma: A necropsy-based study of 414 cases

Claudio Bianchi; Alessandro Brollo; Lucia Ramani; Clara Zuch

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Claudio Bianchi

University of Texas Health Science Center at Tyler

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Carolyn J. Corn

University of Texas Health Science Center at Tyler

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Marion G. Williams

University of Texas Health Science Center at Tyler

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Ronald F. Dodson

University of Texas Health Science Center at Tyler

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Corrado Magnani

University of Eastern Piedmont

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