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Dive into the research topics where Alex Lederman is active.

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Featured researches published by Alex Lederman.


Jornal Vascular Brasileiro | 2006

Tratamento endoluminal de aneurismas anastomóticos na aorta abdominal: relato de dois casos

Ricardo Aun; Fernando Tavares Saliture Neto; Alex Lederman; Hilton Waksman

Proximal anastomosis aneurysm is a rare and severe complication in aortofemoral bypass surgery. Surgical treatment is complex and has a high morbidity and mortality rate. We report two cases of proximal anastomosis aneurysm in late follow up of aortobifemoral bypass surgery, which occurred 15 and 18 years, respectively, after the bypasses and were repaired by the endovascular technique. Both patients progressed well and were submitted to 6- and 12-month follow-up CT scans showing aneurysm exclusion.


Sao Paulo Medical Journal | 2002

Ring-stripping retrograde common carotid endarterectomy: case report

Eduardo Toledo de Aguiar; Alex Lederman; Patrícia Matsunaga

CONTEXT Total occlusion of the common carotid is rare and the indications and techniques for surgical treatment are still a matter of controversy. OBJECTIVE To demonstrate the feasibility of retrograde common carotid endarterectomy. DESIGN Retrospective case report study. SETTING Tertiary care private hospital. PARTICIPANTS Three patients underwent ring-stripping retrograde common carotid endarterectomy. Their ages were 81, 68 and 65 years. All were hypertensive with generalized atherosclerosis, two had diabetes mellitus, and one had undergone coronary artery bypass some years earlier and had non-dialytic chronic renal insufficiency. Symptoms of brain ischemia were present in two patients. All patients had total occlusion of the common carotid, extending from the origin to the bifurcation and localized in the right common carotid in two cases. In two cases the internal carotid artery was also occluded. MAIN MEASUREMENTS Postoperative early mortality and stroke rate, and the medium and long-term endarterectomy patency. RESULTS There were no deaths. One patient had a transient ischemic attack. All endarterectomies were patent after eight months, four years and seven years of follow-up. CONCLUSION There is low mortality, and the procedure can be done through only one cervical incision. Tandem lesions of the carotid arteries can be treated together. It is suitable for long total occlusions of the common carotid, and long-term patency.


Sao Paulo Medical Journal | 2001

Early and late results of carotid endarterectomy: retrospective study of 70 operations

Eduardo Toledo de Aguiar; Alex Lederman; Celso Higutchi; Gerd Schreen

CONTEXT Indications and results of carotid endarterectomy have been defined from clinical multicentric trials like the European Carotid Surgery Trialists, North-American Symptomatic Carotid Endarterectomy Trial and Asymptomatic Carotid Atherosclerosis Study. The patients included in these trials were highly selected, as were the surgeons performing the operations. Clinical practice is different but the same results should be achieved. OBJECTIVE To study indications, technique, early and late results, and whether carotid endarterectomy has been performed in accordance with standards defined by multicentric trials. DESIGN Retrospective case report study. SETTING A tertiary care private hospital. PARTICIPANTS 57 patients, on whom 70 carotid endarterectomies were performed over a 10-year period. The median age was 66.4 +/- 7.8 years; 43 (75.4%) were male, 41 (71.9%) hypertensive, 36 (63.1%) current smokers and 24 (21.0%) had diabetes. Bilateral carotid stenosis was present in 31 (54.3%) patients, peripheral arterial occlusions in 32 (56.1%) and ischemic cardiopathy in 25 (43.1%). All patients had had angiography and 41 (71.9%) had also had a duplex-scan of neck arteries. Cerebral imaging via computerized tomography scan or magnetic resonance imaging was obtained for 36 patients. Patients were followed up over a period of one to 122 months. MAIN MEASUREMENTS early and late post-operative death, early and late post-operative stroke, and recurrence of atheroma plaque and symptoms relative to carotid stenosis. RESULTS There was one post-operative death (1.4%) caused by myocardial infarction and two early strokes (2.8%): a total complication rate of 4.2%. After 3 and 5 years, 95.4% and 81.3% of patients respectively were stroke-free and 72.8% and 67.3% were alive. There were four recurrences and two of them related to stroke. Forty-nine (70%) stenoses operated on were symptomatic. Brain infarction was detected in 59.2% of patients who underwent computerized tomography scan or magnetic resonance imaging. CONCLUSIONS Carotid endarterectomy was done in accordance with international standards. The most frequent cause of late death was myocardial infarction, and recurrences were related to stroke. Patients should be followed up closely.


Vascular Medicine | 2014

Endovascular model of abdominal aortic aneurysm induction in swine

Alex Lederman; Fernando Tavares Saliture Neto; Rimarcs Gomes Ferreira; Luis Francisco Poli de Figueiredo; José Pinhata Otoch; Ricardo Aun; Erasmo Simão da Silva

Abdominal aortic aneurysms are among the main causes of death. The high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental models are useful to understand, train, and develop new treatment and diagnostic methods for this pathology, animal models developed to date are far from ideal. Animals are either too small and do not represent the pathology of humans, or the procedures employ laparotomy, or the aortic behavior does not resemble that of a true aneurysm. We developed a novel, less invasive and effective method to induce true aortic aneurysms in Large White pigs. Animals were submitted to an endovascular chemical induction using either calcium chloride (25%) or swine pancreatic elastase. Controls were exposed to saline solution. All animals were operated on using the same surgical technique under general anesthesia. They were followed weekly with ultrasound examinations and at 4 weeks the aorta was harvested. Although elastase induced only arterial dilation, imaging, histological, and biomechanical studies of the aorta revealed the formation of true aneurysms in animals exposed to calcium chloride. Aneurysms in the latter group had biomechanical failure properties similar to those of human aneurysms. These findings indicate that the endovascular approach is viable and does not cause retroperitoneal fibrosis.


Autopsy and Case Reports | 2015

Feeding tube replacement: not always that simple!

Mateus Quitembo Soares da Silva; Alex Lederman; Ricardo Frank Coelho da Rocha; Rodrigo Montenegro Lourenção

Although surgical gastrostomy is not a technically troublesome surgery, the procedure may be accompanied by unfavorable outcomes. Most complications occur early in the post-operative period and include feeding tube dislodgment, stomal infection, peritonitis, and pneumonia. The authors report the case of an 83-year-old man who underwent a surgical gastrostomy because of a swallowing disorder after an ischemic stroke. Nine months after the procedure, the feeding tube dislodged and a new tube was inserted with a certain delay and with some difficulty, causing a false path and consequently an intrabdominal abscess after diet infusion. The outcome was fatal. The authors call attention for meticulous care with the insertion of feeding tubes and advise the performance of imaging control to assure its precise positioning.


Jornal Vascular Brasileiro | 2009

Inner tubing endograft: a new technique for bifurcation preservation

Alex Lederman; Fernando Tavares Saliture Neto; Boulanger Mioto Netto; Guilherme Linhares Bub; Manoel Lobato; Ricardo Aun

Treating narrow arteries and their bifurcations is a major challenge to the endovascular surgeon. We describe a new endovascular technique that was used to treat a narrow aorta and that may also be used to preserve other bifurcations. Using three straight stents may enable the endovascular surgeon to treat bifurcation while maintaining flow to both distal arteries.


Revista do Colégio Brasileiro de Cirurgiões | 2003

Cirurgia Endoscópica Subfascial de veias Perfurantes Insuficientes (CESPI): experiência inicial

Eduardo Toledo de Aguiar; Alex Lederman; Marina A. Farjallat; Mônica A. Rudner

BACKGROUND: Prevalence of varicose ulcers in Brazil has been estimated as high as 3.6%. Perforator vein insufficiency is the main source for the development of these ulcers. The recently proposed SEPS technique is regarded as minimally invasive approach followed by low complication rates and short in-hospital stay. Our objective is to study the results of subfascial endoscopic perforator surgery associated or not to superficial venous system surgery. METHODS: Prospective, non-controlled ,clinical study. Inclusion criteria were patent deep venous system, patient with primary or secondary venous insufficiency (congenital not included) and an ankle/arm index higher than 0.8; exclusion criteria were: deep vein thrombosis, trauma or orthopedic surgery and deep venous system surgery occurring during post-operative follow-up. All patients had a duplex-scan perfomed before operation. RESULTS: Forty-three lower limbs were operated on since june/97; there were 27 patients with mean age 56.6 years; great saphenous vein, lesser saphenous vein and tributaries stripping were associated in 29 limbs; three limb were classified as C3, 15 as C4, 11 as C5 and 14 as C6. Venous insufficiency was secondary to deep venous thrombosis in 2 limbs. There were no immediate deaths; three to five perforators per limb were ligated; all ulcers healed during a period from two to 15 weeks; there were three infections (6.9%); 19 patients left hospital on 1st, six on 2nd and two on 3rd post-operative day. There was one ulcer recurrence (4.0%) after 10 months (perforator vein left in place). CONCLUSION: the procedure is safe, the hospitalization time is short, ulcer healing occurs mostly within two weeks and recurrence rate depends on a follow-up period at least of five years.


Revista do Hospital das Clínicas | 2002

Trombendarterectomia aorto-femoral

Eduardo Toledo de Aguiar; Alex Lederman; Cid José Sitrângulo Júnior; Pedro Puech-Leão


Jornal Vascular Brasileiro | 2004

Expansão de aneurisma de aorta abdominal após correção endoluminal

Ricardo Aun; Glauco Fernandes Saes; Adriano Tachibana; Alex Lederman; Hilton Waksman; Fernando Tavares Saliture Neto; Otávio Ninomiya


Jornal Vascular Brasileiro | 2005

Ferimentos da artéria subclávia. Estudo retrospectivo de 20 casos

Alex Lederman; Flávia Helena Matta de Paiva; Glauco Fernandes Saes; Ricardo Aun

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Ricardo Aun

University of São Paulo

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Gerd Schreen

University of São Paulo

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Celso Higutchi

University of São Paulo

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Manoel Lobato

University of São Paulo

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