Alex M. Chen | Researchain

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Featured researches published by Alex M. Chen.

Chemical Communications | 2007

Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid

Alex M. Chen; Martha E. Ellison; Andrey V. Peresypkin; Robert M. Wenslow; Narayan Variankaval; Cecile G. Savarin; Theresa K. Natishan; David J. Mathre; Peter G. Dormer; Danielle Euler; Richard G. Ball; Zhixiong Ye; Yaling Wang; Ivan Santos

We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used.

Archive | 2004

Phosphoric acid salt of a dipeptidyl peptidase IV inhibitor.

Stephen Howard Cypes; Alex M. Chen; Russell R. Ferlita; Karl B. Hansen; Ivan Lee; Vicky K. Vydra; Robert M. Wenslow

Archive | 2004

Novel crystalline form of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor

Alex M. Chen; Robert M. Wenslow

Archive | 2004

Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor

Robert M. Wenslow; Joseph D. Armstrong; Alex M. Chen; Stephen Howard Cypes; Russell R. Ferlita; Karl B. Hansen; Christopher M. Lindemann; Evangelia Spartalis

Organic Process Research & Development | 2007

Catalytic, Enantioselective Synthesis of Taranabant, a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Cheng-yi Chen; Lisa F. Frey; Scott Shultz; Debra J. Wallace; Karen Marcantonio; Joeseph F. Payack; Enrique Vazquez; Shawn A. Springfield; George Zhou; Ping Liu; Gerard R. Kieczykowski; Alex M. Chen; Brian Phenix; Utpal K. Singh; Jeff Strine; and Brianne Izzo; Shane W. Krska

Organic Process Research & Development | 2008

Enantioenrichment by Crystallization

Yaling Wang; Alex M. Chen

Organic Process Research & Development | 2008

Purification of Partially Resolved Enantiomeric Mixtures with the Guidance of Ternary Phase Diagram

Alex M. Chen; Yaling Wang; Robert M. Wenslow

Organic Process Research & Development | 2004

Drying an Organic Monohydrate: Crystal Form Instabilities and a Factory-Scale Drying Scheme to Ensure Monohydrate Preservation

Stephen Howard Cypes; Robert M. Wenslow; Scott M. Thomas; Alex M. Chen; Jason G. Dorwart; John R. Corte; Mahmoud Kaba

Archive | 2004

Radiolabeled cannabinoid-1 receptor modulators

Donald Burns; Alex M. Chen; Raymond E. Gibson; Mark T. Goulet; William K. Hagmann; Terence G. Hamill; James P. Jewell; Linus S. Lin; Ping Liu; Andrey V. Peresypkin

Archive | 2005

Formation of tetra-substituted enamides and stereoselective reduction thereof

Kevin R. Campos; Artis Klapars; J. Christopher McWilliams; C. Scott Shultz; Debra J. Wallace; Alex M. Chen; Lisa F. Frey; Andrey V. Peresypkin; Yaling Wang; Robert M. Wenslow; Cheng-yi Chen

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