Alexander A. Brownell

Motor Unit Number Estimation in the Assessment of Performance and Function in Motor Neuron Disease

Motor unit number estimation (MUNE) is a unique electrophysiologic test used to estimate the number of surviving motor units in a muscle or group of muscles. It is used most frequently to monitor lower motor neuron loss in amyotrophic lateral sclerosis and spinal muscle atrophy. Of particular interest is its use as an endpoint measure in clinical trials for these diseases. This article describes the principles of MUNE and the factors that need to be considered, and reviews several techniques that have been used in clinical trials and in monitoring progression. It then reviews experience with MUNE in clinical trials for amyotrophic lateral sclerosis and spinal muscle atrophy and discusses how MUNE correlates with measures of function.

Comparison of three algorithms for multi-motor unit detection and waveform marking

Quantitative EMG (QEMG) techniques include automated motor unit action potential (MUAP) detection and marking of clinically useful waveform metrics. Different computer algorithms are available on modern EMG machines to perform these operations rapidly. However, the efficiency and accuracy of available algorithms are rarely directly compared. We have assessed three commercially available algorithms using both synthesized and biologic interference patterns and found differences among algorithms, some of which are clinically significant. Our results point out the importance of assessing for duplicate MUAPs (same waveform detected as two separate waveforms) and accuracy of markings used to determine MUAP metrics. Muscle Nerve, 2005

A timeline for predicting durable medical equipment needs and interventions for amyotrophic lateral sclerosis patients

ALS is progressive with increasing patient needs for durable medical equipment (DME) and interventions (gastric feeding tube – PEG, and non-invasive ventilation – NIV). We performed a chart review of deceased patients to determine the time-course of needs and their estimated costs. A timeline of needs was based on when clinic personnel felt an item was necessary. The point in time when an item or intervention was needed was expressed as a percentage of a patients total disease duration. A wide range of DME and interventions was needed irrespective of site of ALS symptom onset (bulbar, upper, lower extremity), beginning at 10% of disease duration of lower extremity onset and increasing thereafter for all sites. The cumulative probability of costs of items and interventions began at 25%–50% of disease duration and increased to between

Electrodiagnostic assessment of peripheral neuropathies.

18,000 and

Comparison of standard and pediatric size concentric needle EMG electrodes

32,000 (USD), highest for lower extremity onset due to the cost of wheelchairs. We conclude that a high percentage of ALS patients will need a full spectrum of major DME items and interventions during the second half of disease duration. This results in a linear rise in costs over the second half of the disease duration.

Effects of intramuscular needle position on motor unit action potential metrics.

The authors discuss the techniques and use of electrodiagnosis to help fully characterize peripheral neuropathies, including electrodiagnostic principles, normal findings, correlations between underlying nerve pathology that leads to abnormal electrodiagnostic findings, and how to detect and interpret electrodiagnostic findings.

A survey of stress among amyotrophic lateral sclerosis care providers

OBJECTIVE To compare motor unit action potential (MUAP) metrics recorded by standard and pediatric size concentric EMG electrodes. METHODS Commercial electrodes were used to record MUAPs from biceps brachii, first dorsal interosseous and tibialis anterior muscles in normal subjects and those with amyotrophic lateral sclerosis (ALS). RESULTS In normal subjects, peak amplitude and area were significantly higher when recorded by the pediatric size electrode in tibialis anterior muscles and peak amplitude recorded in first dorsal interosseous muscles. In ALS subjects, peak amplitude was higher recorded by the pediatric size electrode in tibialis muscle but lower when recorded in first dorsal interosseous muscles. CONCLUSIONS Differences of MUAP metrics when recording with standard and pediatric size electrodes do not seem to have a clinical relevance. SIGNIFICANCE Pediatric and standard concentric electrodes record similar MUAP metrics.

Optimizing acquisition time in quantitative electromyography

It is unclear whether there are clinically significant differences in amplitude, duration, and numbers of turns and phases if an electromyographic (EMG) study is performed near to, or far from, the end‐plate zone. The effects of temporal dispersion of arriving muscle‐fiber action potentials on quantitative motor unit action potential (MUAP) metrics were assessed in simulated and biologic muscles. Two muscle simulation models were studied with electrode recording positions near the motor end‐plate zone and 50–75 mm away. When the electrode was moved away from the end‐plate zone, averages of 20 MUAPs significantly decreased in amplitude and area, and increased in numbers of turns and phases, but there was no significant change in duration. In biologic muscles (both normal and pathologic), similar changes in average metrics were observed, but to lesser degrees; few were statistically significant. Zones of innervation in biologic muscles are broadly distributed and, during routine electrode studies, distances between random electrode placements and end‐plate zones are therefore relatively short, leading to clinically insignificant changes in quantitative MUAP metrics with distance from the end‐plate zone. Thus, electrode position within a muscle is unlikely to affect clinical MUAP interpretation. Muscle Nerve, 2007

Effects of high-pass filtering on MUAP metrics.

Abstract Amyotrophic lateral sclerosis (ALS) is a uniformly fatal disease. In the US, care is concentrated in specialized clinics. ALS health care providers likely experience stress, but levels and associated factors and methods to manage them are not known. A questionnaire was designed to assess levels of emotional stress among ALS clinic providers (neurologists and clinic managers) at time of diagnosis, during care of the patient, and at time of the patients death. Also included were questions about diagnostic practice patterns. Sixty-eight Muscular Dystrophy Association and ALS Association certified clinics were surveyed with a 47% response rate. Stress levels ranged from very severe to none at the various clinical stages but did not differ significantly between neurologists and managers. Stress tended to be lower in more experienced providers, although not uniformly so for all situations and time-points. Stress reduction techniques were rated as more effective for managers than for neurologists. Providers reported high levels of job satisfaction but a significant number gave consideration to leaving their positions due to stress and operational issues. In conclusion, stress is experienced by ALS clinic providers and managed by a variety of methods but with limited success.

Optimizing and standardizing quantitative EMG.

Quantitative electromyography (QEMG) relies on a number of discharges of the same motor unit action potential (MUAP) from a train to create an averaged MUAP considered to be representative of a true potential. The train of potentials may be affected by changes in position of the electrode relative to contributing muscle fibers of the motor unit due to operator or subject movement. The effect of changes in electrode position, along with consideration for patient comfort, prompted this study to determine the shortest duration of recording time necessary for sufficient data acquisition for QEMG studies. We determined that 10 seconds of moderate muscle activity is the most reasonable acquisition duration to isolate up to 6 MUAPs at a given electrode site and minimize the effects of movement artifact in the signal. Muscle Nerve, 2009