Alexander A. Fisher

Postprandial Hypotension Predicts All‐Cause Mortality in Older, Low‐Level Care Residents

Objectives: To evaluate which indices of blood pressure (BP) homeostasis are the strongest predictors of mortality in older low‐level‐care residents in long‐term health facilities.

Prolonged QT Interval, Syncope, and Delirium with Galantamine

Objective: TO describe a case of QT interval prolongation, syncope, and delirium associated with galantamine use and to analyze similar cases related to acetylcholinesterase inhibitors (AChls) reported to the Australian Adverse Drug Reaction Advisory Committee (ADRAC). Case Summary: An 85–year-old man with dementia was treated with prolonged release galantamine 8 mg daily for 1.5 years. Three months prior to the current admission, he had a syncopal episode with low blood pressure and bradycardia. Two months later, galantamine was withdrawn, but within 2 weeks, the man developed marked cognitive, behavioral, and functional deterioration and galantamine was restarted. Three weeks later, he developed syncope, delirium, hypotension, and prolonged QT interval with serious cardiac arrhythmias, in addition to vomiting and diarrhea. A complete blood cell count and biochemistry panel performed on admission were normal. No infection was detected. Galantamine and irbesartan were ceased. The delirium fully resolved in 6 days, and the QT interval shortened from 503 to 443 msec (corrected by Bazetts formula) 4 days after discontinuation of galantamine and remained normal. Discussion: In the ADRAC reports, galantamine was associated with 18 cases of delirium/confusion. 8 of syncope, 13 of bradycardia, 6 of other arrhythmias or conducton abnormalities, and 6 of hypotension. Donepezil was associated with 56, 15, 26, 15, and 5, and rivastigmine with 21, 8, 6, 2, and 2, respectively, of these reactions. Five fatal outcomes were reported in association with galantamine, 11 with donepezil, and 3 with rivastigmine, including 3, 6, and 0 sudden deaths, respectively. This case, along with previously published reports and cases identified from the ADRAC database, illustrates that AChls may lead to delirium, syncope, hypotension, and life-threatening arrhythmias. The Naranjo probability scale indicated that galantamine was the probable cause of QT interval prolongation, syncope, and delirium in this patient. Conclusions: Administration of galantamine and other AChls requires vigilance and assessment of risk (actors that may precipitate QT interval prolongation, syncope, and delirium.

Clinical profiles and risk factors for outcomes in older patients with cervical and trochanteric hip fracture: similarities and differences

BackgroundData on clinical characteristics and outcomes in regard to hip fracture (HF) type are controversial. This study aimed to evaluate whether clinical and laboratory predictors of poorer outcomes differ by HF type.MethodsProspective evaluation of 761 consecutively admitted patients (mean age 82.3 ± 8.8 years; 74.9% women) with low-trauma non-pathological HF. Clinical characteristics and short-term outcomes were recorded. Haematological, renal, liver and thyroid status, C-reactive protein, cardiac troponin I, serum 25(OH) vitamin D, PTH, leptin, adiponectin and resistin were determined.ResultsThe cervical compared to the tronchanteric HF group was younger, have higher mean haemoglobin, albumin, adiponectin and resistin and lower PTH levels (all P < 0.05). In-hospital mortality, length of hospital stay (LOS), incidence of post-operative myocardial injury and need of institutionalisation were similar in both groups. Multivariate analysis revealed as independent predictors for in-hospital death in patient with cervical HF male sex, hyperparathyroidism and lower leptin levels, while in patients with trochanteric HF only hyperparathyroidism; for post-operative myocardial injury dementia, smoking and renal impairment in the former group and coronary artery disease (CAD), hyperparathyroidism and hypoleptinaemia in the latter; for LOS > 20 days CAD, and age > 75 years and hyperparathyroidism, respectively. Need of institutionalisation was predicted by age > 75 years and dementia in both groups and also by hypovitaminosis D in the cervical and by hyperparathyroidism in the trochanteric HF.ConclusionsClinical characteristics and incidence of poorer short-term outcomes in the two main HF types are rather similar but risk factors for certain outcomes are site-specific reflecting differences in underlying mechanisms.

Trends in stroke survival incidence rates in older Australians in the new millennium and forecasts into the future.

AIMS The objective of this study is (i) to evaluate trends in the incidence rates of stroke survivors aged 60 years and older over a 11-year period in the Australian Capital Territory (ACT) and (ii) to forecast future trends in Australia until 2051. METHODS Analysis of age- and sex-specific standardized incidence rates of older first-ever stroke survivors in ACT from 1999-2000 to 2009-2010 and projections of number of stroke survivors (NSS) in 2021 and 2051 using 2 models based only on (i) demographic changes and (ii) assuming changing of both incidence rates and demography. RESULTS In the ACT in the first decade of the 21st century, the absolute numbers and age-adjusted standardized incidence rates of stroke survivors (measured as a function of age and period) increased among both men and women aged 60 years or older. The trend toward increased survival rates in both sexes was driven mainly by population aging, whereas the effect of stroke year was more pronounced in men compared with women. The absolute NSS (and the financial burden to the society) in Australia is predicted to increase by 35.5%-59.3% in 2021 compared with 2011 and by 1.6- to 4.6-fold in 2051 if current only demographic (first number) or both demographic and incidence trends (second number) continue. CONCLUSIONS Our study demonstrates favorable trends in stroke survivor rates in Australia in the first decade of the new millennium and projects in the foreseeable future significant increases in the absolute numbers of older stroke survivors, especially among those aged 70 years or older and men.

Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

This narrative review summarises the benefits, risks and appropriate use of acid-suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists, advocating a rationale balanced and individualised approach aimed to minimise any serious adverse consequences. It focuses on current controversies on the potential of ASDs to contribute to infections—bacterial, parasitic, fungal, protozoan and viral, particularly in the elderly, comprehensively and critically discusses the growing body of observational literature linking ASD use to a variety of enteric, respiratory, skin and systemic infectious diseases and complications (Clostridium difficile diarrhoea, pneumonia, spontaneous bacterial peritonitis, septicaemia and other). The proposed pathogenic mechanisms of ASD-associated infections (related and unrelated to the inhibition of gastric acid secretion, alterations of the gut microbiome and immunity), and drug-drug interactions are also described. Both probiotics use and correcting vitamin D status may have a significant protective effect decreasing the incidence of ASD-associated infections, especially in the elderly. Despite the limitations of the existing data, the importance of individualised therapy and caution in long-term ASD use considering the balance of benefits and potential harms, factors that may predispose to and actions that may prevent/attenuate adverse effects is evident. A six-step practical algorithm for ASD therapy based on the best available evidence is presented.

ALTERED BLOOD PRESSURE HOMEOSTASIS IN THE OLDEST OLD AND SURVIVAL

IGT was 2.5 (P 5.01) compared with nonobesity. According to the above results, low economic status and obesity were independent factors associated with DM/IGT. DM/IGT was common, but obesity was rare in the group with low economic status in this rural area. The elderly of low economic itself may have a high risk for suffering DM/IGT because of their lifestyle; some hypotheses for this are suggested. The first is the unbalanced diet of sticky rice, which has more calories than ordinary rice, with cheo (local pepper sauce) and a paucity of other foods. The second is the hypothesis of ‘‘fetal origins of disease,’’ which postulates that early undernutrition causes an irreversible differentiation of the metabolic system, which may, in turn, increase the risk of DM in adulthood or old age. Poor old people in rural areas may be vulnerable to IGT/DM because of those causes and others. Recently, energy-dense foods with more sugar and fats are available near this rural area. Obesity was associated with DM/IGT especially in people of moderate or high economic status in this study. The area may be under siege from nutritional transition with economic globalization. For the prevention of obesity and DM/IGT in vulnerable people, especially those of low economic status, it is important to recognize that, not only high, but also low economic status may be a risk factor for DM, and the causes in each of them should be pursued to prevent DM and its complications.

Is the current anti-osteoporotic therapy paradigm good enough?

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Six-fold increased risk of hip fracture in older Australians (≥60 years) with dementia

IntroductionThe objectives were: (1) to estimate the prevalence of dementia in older people with hip fracture (HF) and (2) to evaluate the significance of dementia and residential care as risk factors for HF in the Australian Capital Territory (ACT), Australia.MethodsWe performed a prospective study of 555 consecutive patients (≥60 years) with HF (mean age 82.6±7.9 (SD) years; 74.2% women) within 162,608 person-years of observation. The main predictor variables of HF were, pre-fracture diagnosed dementia of any type and residential status. ACT population estimates and age- and gender-specific prevalence rates of dementia in the ACT population were used to calculate the relative risk of HF in demented people.ResultsOf those with HF, 176 (31.7%) were diagnosed with dementia prior to the fracture. Multiple logistic regression analysis revealed that dementia in HF patients was associated with history of stroke (OR=2.2; 95% CI 1.2–4.0; p=0.008), residential care (OR=6.7; 95% CI 4.5–10.2; p=0.001) and older age (OR=1.03; 95% CI 1.0–1.1; p=0.036). The overall relative risk (RR) for HF in persons with dementia was 6.3 (95% CI 5.1–7.1) times higher than in those without pre-fracture dementia, and the RR in the young-old (60–79 years) with dementia was higher than in the old-old (≥85 years). The RR of HF for demented persons living in long-term residential care facilities compared to the non-demented age-matched community-dwelling population was 16.3 (95% CI 14.4–18.2; p=0.001).ConclusionsThis study demonstrated a high prevalence of demented people among HF patients and a 6.3-fold risk for HF in older persons with dementia. This risk is almost 2.6 times greater in demented people living in residential care. These data may be useful in health policy decisions and strongly support development of targeted HF prevention strategies, planning and allocation of resources and prioritisation of prevention efforts toward those with dementia, especially in residential care.