Alexander V. Nyuchev
N. I. Lobachevsky State University of Nizhny Novgorod
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Publication
Featured researches published by Alexander V. Nyuchev.
Chemistry of Heterocyclic Compounds | 2012
A. Yu. Fedorov; Alexander V. Nyuchev; I. P. Beletskaya
Methods of synthesis and functionalization of coumarins using metal complex and organic catalysis are considered in the review.
European Journal of Medicinal Chemistry | 2018
Vasilii F. Otvagin; Alexander V. Nyuchev; Natalia S. Kuzmina; Ivan D. Grishin; Andrei Gavryushin; Yuliya V. Romanenko; Oscar I. Koifman; Dmitrii V. Belykh; Nina N. Peskova; Natalia Y. Shilyagina; Irina V. Balalaeva; Alexey Yu. Fedorov
A new water-soluble conjugate, consisting of a chlorin-based photosensitizing part, and a 4-arylaminoquinazoline moiety with high potential affinity to an epidermal growth factor receptors (EGFR) and vascular endothelial growth factor receptors (VEGFR), suitable for photodynamic therapy (PDT), was synthesized starting from methylpheophorbide-a in seven steps. An increased accumulation of this compound in A431 cells with high level of EGFR expression, in comparison with CHO and HeLa cells with low EGFR expression was observed. The prepared conjugate exhibits dark and photoinduced cytotoxicity at micromolar concentrations with IC50dark/IC50light ratio of 11-18. In tumor-bearing mice, the conjugate preferentially accumulates in the tumor tissue.
Separation and Purification Technology | 2017
Alsu I. Akhmetshina; Olesya R. Gumerova; Artem A. Atlaskin; Anton N. Petukhov; Tatyana S. Sazanova; Nail R. Yanbikov; Alexander V. Nyuchev; Evgeny N. Razov; I. V. Vorotyntsev
Tetrahedron Letters | 2011
Alexander V. Nyuchev; Ekaterina A. Sharonova; Nina A. Lenshina; Andrew S. Shavyrin; M. A. Lopatin; Irina V. Balalaeva; I. P. Beletskaya; Alexey Yu. Fedorov
Russian Chemical Bulletin | 2011
A. N. Selikhov; Yulia B. Malysheva; Alexander V. Nyuchev; Nikolay S. Sitnikov; E. A. Sharonova; A. S. Shavyrin; Sébastien Combes; A. Yu. Fedorov
ACS Sustainable Chemistry & Engineering | 2017
Alsu I. Akhmetshina; Anton N. Petukhov; Andrey V. Vorotyntsev; Alexander V. Nyuchev; I. V. Vorotyntsev
Synthesis | 2014
Alexander V. Nyuchev; Kirill V. Schegravin; Michail A. Lopatin; Valery V. Fokin; I. P. Beletskaya; Alexey Yu. Fedorov
Synthesis | 2015
Alexander V. Nyuchev; Vasiliy F. Otvagin; Andrei Gavryushin; Yuliya I. Romanenko; Oscar I. Koifman; Dmitrii V. Belykh; Hans-Günther Schmalz; Alexey Yu. Fedorov
Applied Catalysis B-environmental | 2018
Andrey V. Vorotyntsev; Anton N. Petukhov; Dmitriy A. Makarov; Evgeny N. Razov; I. V. Vorotyntsev; Alexander V. Nyuchev; Natalia I. Kirillova; V. M. Vorotyntsev
The Journal of Chemical Thermodynamics | 2019
Alsu I. Akhmetshina; Anton N. Petukhov; Olesya R. Gumerova; Andrey V. Vorotyntsev; Alexander V. Nyuchev; I. V. Vorotyntsev
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