Alexander W. Turner

Biomechanical comparison of transpedicular versus intralaminar C2 fixation in C2-C6 subaxial constructs.

Study Design. Biomechanical study. Objective. To compare the relative rigidity of C2 transpedicular versus intralaminar fixation with and without offset connectors in C2–C6 subaxial constructs. Summary of Background Data. Insufficient biomechanical data exists on C2 laminar fixation in subaxial constructs, and no study has considered C2–C6 subaxial constructs or the use of offset connectors. Methods. Six fresh-frozen cadaveric cervical spines underwent rigidity testing in the intact condition and after a destabilizing C3–C6 laminectomy. Specimens were instrumented with 20 mm pedicle and 20 mm intralaminar screws at C2, and with 14 mm lateral mass screws from C3–C6. In random order, three conditions (C2 pedicle screws, C2 laminar screws, and C2 laminar screws with offset connectors) were tested in flexion-extension, axial rotation, and lateral bending. Results. Laminar screws in C2–C6 constructs were equivalent to transpedicular fixation in flexion-extension (P = 0.985), were significantly more rigid than pedicle screws in axial rotation (P = 0.002), and were significantly less rigid than pedicle screws in lateral bending (P = 0.002). Laminar screw constructs were more rigid than the intact condition in all planes.

Biomechanics of lateral lumbar interbody fusion constructs with lateral and posterior plate fixation

OBJECTnLumbar interbody fusion is indicated in the treatment of degenerative conditions. Laterally inserted interbody cages significantly decrease range of motion (ROM) compared with other cages. Supplemental fixation options such as lateral plates or spinous process plates have been shown to provide stability and to reduce morbidity. The authors of the current study investigate the in vitro stability of the interbody cage with a combination of lateral and spinous process plate fixation and compare this method to the established bilateral pedicle screw fixation technique.nnnMETHODSnTen L1-5 specimens were evaluated using multidirectional nondestructive moments (± 7.5 N · m), with a custom 6 degrees-of-freedom spine simulator. Intervertebral motions (ROM) were measured optoelectronically. Each spine was evaluated under the following conditions at the L3-4 level: intact; interbody cage alone (stand-alone); cage supplemented with lateral plate; cage supplemented with ipsilateral pedicle screws; cage supplemented with bilateral pedicle screws; cage supplemented with spinous process plate; and cage supplemented with a combination of lateral plate and spinous process plate. Intervertebral rotations were calculated, and ROM data were normalized to the intact ROM data.nnnRESULTSnThe stand-alone laterally inserted interbody cage significantly reduced ROM with respect to the intact state in flexion-extension (31.6% intact ROM, p < 0.001), lateral bending (32.5%, p < 0.001), and axial rotation (69.4%, p = 0.002). Compared with the stand-alone condition, addition of a lateral plate to the interbody cage did not significantly alter the ROM in flexion-extension (p = 0.904); however, it was significantly decreased in lateral bending and axial rotation (p < 0.001). The cage supplemented with a lateral plate was not statistically different from bilateral pedicle screws in lateral bending (p = 0.579). Supplemental fixation using a spinous process plate was not significantly different from bilateral pedicle screws in flexion-extension (p = 0.476). The combination of lateral plate and spinous process plate was not statistically different from the cage supplemented with bilateral pedicle screws in all the loading modes (p ≥ 0.365).nnnCONCLUSIONSnA combination of lateral and spinous process plate fixation to supplement a laterally inserted interbody cage helps achieve rigidity in all motion planes similar to that achieved with bilateral pedicle screws.

Craniocervical fixation with occipital condyle screws: Biomechanical analysis of a novel technique

Study Design. A human cadaveric biomechanical study comparing craniocervical fixation techniques. Objective. To quantitatively compare the biomechanical stability of a new technique for occipitocervical fixation using the occipital condyles with an established method for craniocervical spine fusion. Summary of Background Data. Stabilization of the occipitocervical junction remains a challenge. The occiput does not easily accommodate instrumentation because of access and spatial constraints. In fact, the area available for the implant fixation is limited and can be restricted further when a suboccipital craniectomy has been performed, posing a challenge to current fixation techniques. Occipital screws are also associated with the potential for intracranial complications. Methods. Six fresh frozen cadaveric specimens occiput-C4 were tested intact, after destabilization and after fixation as follows: (1) occipital plate with C1 lateral mass screws and C2 pars screws and (2) occipital condyle screws with C1 lateral mass screws and C2 pars screws. Specimens were loaded in a custom spine testing apparatus and subjected to the following tests, all performed under 50-N unconstrained axial preload: flexion, extension, lateral bending, and axial rotation at 1.5 Nm. The constructs were statistically compared with a one-way analysis of variance and compared with the intact condition. Results. Motions were reduced by ∼80% compared with the intact condition for both configurations under all motions. There were no statistically significant differences in the range of motion (ROM) between the 2 instrumentation conditions. The mean values indicated decreased ROM with the novel occipital condyle screw construct in comparison with the standard occipital plate and rod system. Conclusion. Craniocervical stabilization using occipital condyle screws as the sole cephalad fixation point is biomechanically equivalent with regard to the modes tested (ROM and stiffness) to the standard occipital plate construct.

The effect of posterior polyester tethers on the biomechanics of proximal junctional kyphosis: a finite element analysis

OBJECTIVE Proximal junctional kyphosis (PJK) remains problematic following multilevel instrumented spine surgery. Previous biomechanical studies indicate that providing less rigid fixation at the cranial aspect of a long posterior instrumented construct, via transition rods or hooks at the upper instrumented vertebra (UIV), may provide a gradual transition to normal motion and prevent PJK. The purpose of this study was to evaluate the ability of posterior anchored polyethylene tethers to distribute proximal motion segment stiffness in long instrumented spine constructs. METHODS A finite element model of a T7-L5 spine segment was created to evaluate range of motion (ROM), intradiscal pressure, pedicle screw loads, and forces in the posterior ligament complex within and adjacent to the proximal terminus of an instrumented spine construct. Six models were tested: 1) intact spine; 2) bilateral, segmental pedicle screws (PS) at all levels from T-11 through L-5; 3) bilateral pedicle screws from T-12 to L-5 and transverse process hooks (TPH) at T-11 (the UIV); 4) pedicle screws from T-11 to L5 and 1-level tethers from T-10 to T-11 (TE-UIV+1); 5) pedicle screws from T-11 to L-5 and 2-level tethers from T-9 to T-11 (TE-UIV+2); and 6) pedicle screws and 3-level tethers from T-8 to T-11 (TE-UIV+3). RESULTS Proximal-segment range of motion (ROM) for the PS construct increased from 16% at UIV-1 to 91% at UIV. Proximal-segment ROM for the TPH construct increased from 27% at UIV-1 to 92% at UIV. Posterior tether constructs distributed ROM at the UIV and cranial adjacent segments most effectively; ROM for TE-UIV+1 was 14% of the intact model at UIV-1, 76% at UIV, and 98% at UIV+1. ROM for TE-UIV+2 was 10% at UIV-1, 51% at UIV, 69% at UIV+1, and 97% at UIV+2. ROM for TE-UIV+3 was 7% at UIV-1, 33% at UIV, 45% at UIV+1, and 64% at UIV+2. Proximal segment intradiscal pressures, pedicle screw loads, and ligament forces in the posterior ligament complex were progressively reduced with increasing number of posterior tethers used. CONCLUSIONS Finite element analysis of long instrumented spine constructs demonstrated that posterior tethers created a more gradual transition in ROM and adjacent-segment stress from the instrumented to the noninstrumented spine compared with all PS and TPH constructs. Posterior tethers may limit the biomechanical risk factor for PJK; however, further clinical research is needed to evaluate clinical efficacy.

Biomechanical stability of lateral interbody implants and supplemental fixation in a cadaveric degenerative spondylolisthesis model.

Study Design. In vitro cadaveric biomechanical study of lateral interbody cages and supplemental fixation in a degenerative spondylolisthesis (DS) model. Objective. To investigate changes in shear and flexion-extension stability of lateral interbody fusion constructs. Summary of Background Data. Instability associated with DS may increase postoperative treatment complications. Several groups have investigated DS in cadaveric spines. Extreme lateral interbody fusion (XLIF) cages with supplemental fixation have not previously been examined using a DS model. Methods. Seven human cadaveric L4–L5 motion segments were evaluated using flexion-extension moments to ±7.5 N·m and anterior-posterior (A-P) shear loading of 150 N with a static axial compressive load of 300 N. Conditions were: (1) intact segment, (2) DS simulation with facet resection and lateral discectomy, (3) standalone XLIF cage, (4) XLIF cage with (1) lateral plate, (2) lateral plate and unilateral pedicle screws contralateral to the plate (PS), (3) unilateral PS, (4) bilateral PS, (5) spinous process plate, and (6) lateral plate and spinous process plate. Flexion-extension range of motion (ROM) data were compared between conditions and with results from a previous study without DS simulation. A-P shear displacements were compared between conditions. Results. Flexion-extension ROM after DS destabilization increased significantly by 181% of intact ROM. With the XLIF cage alone, ROM decreased to 77% of intact. All conditions were less stable than corresponding conditions with intact posterior elements except those including the spinous process plate. Under shear loading, A-P displacement with the XLIF cage alone increased by 2.2 times intact. Bilateral PS provided the largest reduction of A-P displacement, whereas the spinous process plate alone provided the least. Conclusion. This is the first in vitro shear load testing of XLIF cages with supplemental fixation in a cadaveric DS model. The variability in sagittal plane construct stability, including significantly increased flexion-extension ROM found with most fixation conditions including bilateral PS may explain some clinical treatment complications in DS with residual instability. Level of Evidence: N/A

Femoral nerve strain at L4-L5 is minimized by hip flexion and increased by table break when performing lateral interbody fusion.

Study Design. Anatomic studies have demonstrated that nerves and blood vessels have excursion with extremity range of motion. We have measured femoral nerve excursion with the lateral lumbar transpsoas interbody fusion (LLIF) procedure with changes in table flexion and ipsilateral hip flexion on both sides of 5 cadavers. Objective. To determine the effect of hip range of motion on femoral nerve strain near the L4–L5 disc space because it pertains to the LLIF procedure. Summary of Background Data. Postoperative thigh symptoms are common after the LLIF procedure. Although nerve strain in general has been shown to impair function, it has not been tested specifically with LLIF. Methods. Five cadavers were placed in the lateral position as though undergoing the L4–L5 LLIF procedure. Radiographical markers were implanted into the femoral nerve. Lateral and anteroposterior fluoroscopic images were recorded with 0° initial table flexion and the hip at 0, 20, 40, and 60° flexion. The table was flexed to 40°, and the process repeated. Examination was repeated on the contralateral side and nerve strain and excursion were calculated. Results. Table flexion results in preloading the femoral nerve when approaching L4–L5. Nerve strain was highest with the table flexed to 40° and the hip at 0° (average, 6%–7%). Strain in the femoral nerve decreased with increasing hip flexion for both table flexion angles. Anterior displacement of the nerve by approximately 1.5 mm was noted at 40° table flexion compared with 0°. Conclusion. Strain values with table flexion of 40° approached those associated with reduced neural blood flow in animal studies. Table flexion should be minimized to the extent possible when performing L4–L5 LLIF. Additionally, hip flexion to 60° can neutralize the neural strain that occurs with aggressive table flexion. Level of Evidence: N/A