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Dive into the research topics where Alexandra Papadopoulos is active.

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Featured researches published by Alexandra Papadopoulos.


European Journal of Cancer Prevention | 2013

Tobacco smoking, alcohol drinking and risk of oral cavity cancer by subsite: results of a French population-based case-control study, the ICARE study.

Loredana Radoï; Sophie Paget-Bailly; Diane Cyr; Alexandra Papadopoulos; Florence Guida; Annie Schmaus; Sylvie Cénée; Gwenn Menvielle; Matthieu Carton; Bénédicte Lapôtre-Ledoux; Patricia Delafosse; Isabelle Stücker; Danièle Luce

The objective was to examine the role of tobacco smoking and alcohol drinking in the incidence of oral cavity cancer by subsite in France, a high-incidence area. We analysed detailed data on lifelong tobacco smoking and alcohol drinking from 772 oral cavity cancer cases and 3555 controls included in a population-based case–control study, the ICARE study. Tobacco smoking increased the risk of oral cavity cancer even for the smaller quantities and durations, whereas alcohol drinking increased this risk only in heavy drinkers who were also ever smokers. The combined effect of smoking and drinking was greater than multiplicative. The floor of the mouth was the subsite that was the most affected by the harmful effects of tobacco and alcohol, whereas the gums were less susceptible. The risk associated with tobacco and alcohol consumption did not differ between intraoral cavity and subsites usually included in the oropharynx (soft palate and base of the tongue). Population-attributable risks for oral cavity cancer were 78.6% for tobacco smoking, 7.3% for alcohol drinking and 80.7% for tobacco and/or alcohol consumption. These results indicate that regular oral check-ups should be targeted at smokers and heavy drinkers, and that prevention efforts should be focused on smoking cessation.


Journal of Occupational and Environmental Medicine | 2011

Risk of lung cancer and occupational history: results of a French population-based case-control study, the ICARE study.

Florence Guida; Alexandra Papadopoulos; Gwenn Menvielle; Mireille Matrat; Joelle Fevotte; Sylvie Cénée; Diane Cyr; Annie Schmaus; Matthieu Carton; Sophie Paget-Bailly; Loredana Radoï; Chloé Tarnaud; Simona Bara; Brigitte Trétarre; Danièle Luce; Isabelle Stücker

Objectives: To assess the risk of lung cancer associated with occupations and industries. Methods: A French population-based case-control study included 2923 cases and 3555 controls. Lifelong occupational history was collected. Two lists of occupations known (A) or suspected (B) to be associated with lung cancer were used. Occupations and industries not included in these lists were also explored. Results: Among men, the smoking-adjusted odds ratio was 1.97 for list A (attributable fraction: 12.3%), 1.4 for list B (due especially to carpenters/joiners and transport workers). Among unlisted occupations, excess risks were found for welders, plumbers, and several construction crafts. Odds ratios among women were elevated for list A, list B (due especially to launderers/dry cleaners), cleaners and hairdressers. Conclusions: These results confirm the role of known occupations and give insight into new occupational risk factors among men and women.


Clinical & Experimental Allergy | 2016

Peanut-allergic patients in the MIRABEL survey: characteristics, allergists' dietary advice and lessons from real life

Antoine Deschildre; Cf Elegbédé; Jocelyne Just; Olivier Bruyère; X. Van Der Brempt; Alexandra Papadopoulos; E. Beaudouin; Jm Renaudin; Amélie Crépet; D.A. Moneret-Vautrin

The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to study the presence of peanut traces in pre‐packed foods with/without precautionary allergen labelling (PAL), and to combine these data to quantify allergic risk and produce a cost/benefit analysis. This paper reports a real‐life observatory of 785 patients (< 16y: 86%): medical characteristics, eliciting doses (ED) in real life and in oral food challenges (OFC), factors associated with severe reactions, allergist dietary advice and patients’ anxiety regarding their allergy.


Monthly Notices of the Royal Astronomical Society | 2017

HELP: XID+, The Probabilistic De-blender for Herschel SPIRE maps

P. D. Hurley; Seb Oliver; M. Betancourt; C. Clarke; William I. Cowley; S. Duivenvoorden; D. Farrah; Matthew Joseph Griffin; Cedric G. Lacey; E. Le Floc'h; Alexandra Papadopoulos; M. Sargent; Jillian M. Scudder; M. Vaccari; I. Valtchanov; Lingyu Wang

We have developed a new prior-based source extraction tool, xid+, to carry out photometry in the Herschel SPIRE (Spectral and Photometric Imaging Receiver) maps at the positions of known sources. xid+ is developed using a probabilistic Bayesian framework that provides a natural framework in which to include prior information, and uses the Bayesian inference tool Stan to obtain the full posterior probability distribution on flux estimates. In this paper, we discuss the details of xid+ and demonstrate the basic capabilities and performance by running it on simulated SPIRE maps resembling the COSMOS field, and comparing to the current prior-based source extraction tool desphot. Not only we show that xid+ performs better on metrics such as flux accuracy and flux uncertainty accuracy, but we also illustrate how obtaining the posterior probability distribution can help overcome some of the issues inherent with maximum-likelihood-based source extraction routines. We run xid+ on the COSMOS SPIRE maps from Herschel Multi-Tiered Extragalactic Survey using a 24-μm catalogue as a positional prior, and a uniform flux prior ranging from 0.01 to 1000 mJy. We show the marginalized SPIRE colour–colour plot and marginalized contribution to the cosmic infrared background at the SPIRE wavelengths. xid+ is a core tool arising from the Herschel Extragalactic Legacy Project (HELP) and we discuss how additional work within HELP providing prior information on fluxes can and will be utilized. The software is available at https://github.com/H-E-L-P/XID_plus. We also provide the data product for COSMOS. We believe this is the first time that the full posterior probability of galaxy photometry has been provided as a data product.


Journal of Occupational and Environmental Medicine | 2013

Risk of lung cancer associated with occupational exposure to mineral wools: updating knowledge from a french population-based case-control study, the ICARE study.

Florence Guida; Sophie Paget-Bailly; Farida Lamkarkach; Oumar Gaye; Stéphane Ducamp; Gwenn Menvielle; Alexandra Papadopoulos; Mireille Matrat; Joelle Fevotte; Sylvie Cénée; Diane Cyr; Annie Schmaus; Matthieu Carton; Loredana Radoï; Bénédicte Lapôtre-Ledoux; F. Molinié; Danièle Luce; Isabelle Stücker

Objectives: To assess the risk of lung cancer associated with exposure to mineral wools (MWs), while taking into account smoking, asbestos, and crystalline silica exposures. Methods: The analyses were restricted to men (1350 cases and 1912 controls). Lifelong occupational history was collected. MWs and asbestos exposures were assessed, using task-exposure matrices and silica exposure, a job-exposure matrix. Results: We observed consistent not-significant increased risks of lung cancer of the same order of magnitude among workers exposed to high levels of MWs (odds ratio, 1.4; 95% confidence interval: 0.9 to 2.2; for highest quartile of the Cumulative Exposure Index). Conclusions: These results do not allow to draw firm conclusion about a carcinogenic effect of MWs on the lung, but they cannot exclude it. Given the high number of potentially exposed workers, it will be necessary to replicate them in a future further removed from the asbestos ban.


Food and Chemical Toxicology | 2014

TDS exposure project: Relevance of the Total Diet Study approach for different groups of substances

Karine Vin; Alexandra Papadopoulos; Francesco Cubadda; Federica Aureli; Hatice Imge Oktay Basegmez; Marilena D’Amato; Sam De Coster; Laura D’Evoli; María Teresa López Esteban; Martina Jurković; Massimo Lucarini; Hayrettin Ozer; Pedro Mario Fernández San Juan; Isabelle Sioen; Darja Sokolić; Aida Turrini; Véronique Sirot

A method to validate the relevance of the Total Diet Study (TDS) approach for different types of substances is described. As a first step, a list of >2800 chemicals classified into eight main groups of relevance for food safety (natural components, environmental contaminants, substances intentionally added to foods, residues, naturally occurring contaminants, process contaminants, contaminants from packaging and food contact materials, other substances) has been established. The appropriateness of the TDS approach for the different substance groups has then been considered with regard to the three essential principles of a TDS: representativeness of the whole diet, pooling of foods and food analyzed as consumed. Four criteria were considered for that purpose (i) the substance has to be present in a significant part of the diet or predominantly present in specific food groups, (ii) a robust analytical method has to be available to determine it in potential contributors to the dietary exposure of the population, and (iii) the dilution impact of pooling and (iv) the impact of everyday food preparation methods on the concentration of the substance are assessed. For most of the substances the TDS approach appeared to be relevant and any precautions to be taken are outlined.


Journal of Occupational and Environmental Medicine | 2013

Occupation and head and neck cancer risk in men: results from the ICARE study, a French population-based case-control study.

Sophie Paget-Bailly; Florence Guida; Matthieu Carton; Gwenn Menvielle; Loredana Radoï; Diane Cyr; Annie Schmaus; Sylvie Cénée; Alexandra Papadopoulos; Joelle Fevotte; Corinne Pilorget; Michel Velten; Anne-Valérie Guizard; Isabelle Stücker; Danièle Luce

Objective:To investigate the associations between occupations and head and neck (HN) cancer risk in men. Methods:ICARE is a French population-based case–control study on HN cancer. Analyses included 1833 cases and 2747 controls. Complete occupational history was collected. Odds ratios (ORs) were estimated for occupations and industries ever held and according to duration of employment. Results:Elevated ORs, increasing with duration of employment, were observed for several occupations, including cleaners (OR = 1.7; 95% confidence interval [CI], 1.0 to 2.8), launderers (OR = 6.8; CI, 1.3 to 34.4), firefighters (OR = 3.9; CI, 1.4 to 11.2), several agricultural occupations, welders (OR = 1.9; CI, 1.3 to 2.8), structural metal preparers and erectors (OR = 2.1; CI, 1.2 to 3.7), rubber workers (OR = 2.0; CI, 1.0 to 3.9), several construction occupations, and material-handling equipment operators (OR = 1.8; CI, 1.1 to 2.9). Analyses by industry corroborated these findings. Conclusions:These results confirmed the role of occupational exposures in HN cancer.


Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment | 2015

Establishing a food list for a Total Diet Study: how does food consumption of specific subpopulations need to be considered?

Y. Akhandaf; S. De Henauw; Marcela Dofkova; J. Ruprich; Alexandra Papadopoulos; Véronique Sirot; Mark Kennedy; Hannah Pinchen; Katrin Blume; Oliver Lindtner; A.L. Brantsaeter; H.M. Meltzer; Isabelle Sioen

A Total Diet Study (TDS) consists of selecting, collecting and analysing commonly consumed foods to obtain concentration data of different chemical compounds in foods as eaten. A TDS food list summarises the most consumed foods and represents the dietary habits of the general population of the country under study. The work reported here investigated whether TDS food lists that were initially designed for the whole population of the country under study also sufficiently cover the dietary pattern of specific subpopulations that are extra vulnerable for certain contaminants. The work was performed using data of three European countries: the Czech Republic, France and the UK. Each national food consumption database was combined with the corresponding national TDS food list (containing 336, 212 and 119 food items for the Czech Republic, France and the UK, respectively). The data were aggregated on the highest level of hierarchy of FoodEx-1, a pan-European food classification system, including 20 main FoodEx-1 groups. For the group ‘milk and dairy products’, the coverage of the consumption by the food list was investigated for more refined subgroups. For each food group or subgroup and country, the average percentage of coverage of the diet by the national TDS food list was calculated for different subpopulations, including children versus adults, women versus men, vegetarians versus non-vegetarians, and women of child-bearing age versus older women. The average diet of the different subpopulations was sufficiently covered by the food list of the Czech Republic and France. For the UK the average coverage was low due to a different food-coding approach and because food lists were not derived directly from national food consumption data. At the level of the 20 main food groups, differences between the subpopulations with respect to the average coverage of consumption by the TDS food list were minimal. The differences were more pronounced when looking in detail at the coverage of the dairy consumption. TDS food lists based on the mean consumption of the general population are also applicable to study the chemical exposure of different subpopulations, e.g. children, women of child-bearing age and vegetarians. This lowers the effort when performing a TDS.


International Journal of Cancer | 2017

Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium

Soumaya Ben Khedher; Monica Neri; Alexandra Papadopoulos; David C. Christiani; Nancy Diao; Curtis C. Harris; Susan Olivo-Marston; Ann G. Schwartz; Michele L. Cote; Anita Koushik; Jack Siemiatycki; Maria Teresa Landi; Rayjean J. Hung; John McLaughlin; Eric J. Duell; Angeline S. Andrew; Irene Orlow; Bernard J. Park; Hermann Brenner; Kai Uwe Saum; Angela Cecilia Pesatori; Isabelle Stücker

Many clinical features of lung cancer are different in women and men. Sex steroid hormones exert effects in nonreproductive organs, such as the lungs. The association between menstrual and childbearing factors and the risk of lung cancer among women is still debated. We performed a pooled analysis of eight studies contributing to the International Lung Cancer Consortium (4,386 cases and 4,177 controls). Pooled associations between menstrual or reproductive factors and lung cancer were estimated using multivariable unconditional logistic regression. Subgroup analyses were done for menopause status, smoking habits and histology. We found no strong support for an association of age at menarche and at menopause with lung cancer, but peri/postmenopausal women were at higher risk compared to premenopausal (OR 1.47, 95% CI 1.11–1.93). Premenopausal women showed increased risks associated with parity (OR 1.74, 95% CI 1.03–2.93) and number of children (OR 2.88, 95% CI 1.21–6.93 for more than 3 children; p for trend 0.01) and decreased with breastfeeding (OR 0.54, 95% CI 0.30–0.98). In contrast, peri/postmenopausal subjects had ORs around unity for the same exposures. No major effect modification was exerted by smoking status or cancer histology. Menstrual and reproductive factors may play a role in the genesis of lung cancer, yet the mechanisms are unclear, and smoking remains the most important modifiable risk factor. More investigations in large well‐designed studies are needed to confirm these findings and to clarify the underlying mechanisms of gender differences in lung cancer risk.


Publications of the Astronomical Society of Australia | 2017

Tracing the Evolution of Dust Obscured Star Formation and Accretion Back to the Reionisation Epoch with SPICA

C. Gruppioni; L. Ciesla; E. Hatziminaoglou; F. Pozzi; G. Rodighiero; P. Santini; Lee Armus; M. Baes; J. Braine; Vassilis Charmandaris; D. L. Clements; N. Christopher; H. Dannerbauer; A. Efstathiou; E. Egami; J. A. Fernández-Ontiveros; Fabio Fontanot; A. Franceschini; E. González-Alfonso; Matthew Joseph Griffin; Hidehiro Kaneda; L. Marchetti; Pierluigi Monaco; Takao Nakagawa; Takashi Onaka; Alexandra Papadopoulos; C. Pearson; I. Perez-Fournon; P. G. Pérez-González; Pieter Roelfsema

Our current knowledge of star formation and accretion luminosity at high-redshift (z>3-4), as well as the possible connections between them, relies mostly on observations in the rest-frame ultraviolet (UV), which are strongly affected by dust obscuration. Due to the lack of sensitivity of past and current infrared (IR) instrumentation, so far it has not been possible to get a glimpse into the early phases of the dust-obscured Universe. Among the next generation of IR observatories, SPICA, observing in the 12-350 micron range, will be the only facility that can enable us to make the required leap forward in understanding the obscured star-formation rate and black-hole accretion rate densities (SFRD and BHARD, respectively) with respect to what Spitzer and Herschel achieved in the mid- and far-IR at z<3. In particular, SPICA will have the unique ability to trace the evolution of the obscured SFRD and BHARD over cosmic time, from the peak of their activity back to the reionisation epoch (i.e., 3<z<6-7), where its predecessors had severe limitations. Here we discuss the potential of both deep and shallow photometric surveys performed with the SPICA mid-IR instrument (SMI), enabled by the very low level of impact of dust obscuration in a band centred at 34 micron. These unique unbiased photometric surveys that SPICA will perform will be followed up by observations both with the SPICA spectrometers and with other facilities at shorter and longer wavelengths, with the aim to fully characterise the evolution of AGNs and star-forming galaxies after re-ionisation.

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Stéphan Marette

Institut national de la recherche agronomique

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