Alexandra S. Bullough
University of Michigan
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Featured researches published by Alexandra S. Bullough.
American Journal of Obstetrics and Gynecology | 2012
Louise M. O'Brien; Alexandra S. Bullough; Jocelynn T. Owusu; Kimberley A. Tremblay; Cynthia Brincat; Mark C. Chames; John D. Kalbfleisch; Ronald D. Chervin
OBJECTIVE This study aimed to prospectively examine the impact of chronic vs pregnancy-onset habitual snoring on gestational hypertension, preeclampsia, and gestational diabetes. STUDY DESIGN Third-trimester pregnant women were recruited from a large, tertiary medical center from March 2007 through December 2010 and screened for the presence and duration of habitual snoring, as a known marker for sleep-disordered breathing. Clinical diagnoses of gestational hypertension, preeclampsia, and gestational diabetes were obtained. RESULTS Of 1719 pregnant women, 34% reported snoring, with 25% reporting pregnancy-onset snoring. After adjusting for confounders, pregnancy-onset, but not chronic, snoring was independently associated with gestational hypertension (odds ratio, 2.36; 95% confidence interval, 1.48-3.77; P < .001) and preeclampsia (odds ratio, 1.59; 95% confidence interval, 1.06-2.37; P = .024) but not gestational diabetes. CONCLUSION New-onset snoring during pregnancy is a strong risk factor for gestational hypertension and preeclampsia. In view of the significant morbidity and health care costs associated with hypertensive diseases of pregnancy, simple screening of pregnant women may have clinical utility.
Sleep | 2013
Louise O'Brien; Alexandra S. Bullough; Jocelynn T. Owusu; Kimberley A. Tremblay; Cynthia Brincat; Mark C. Chames; John D. Kalbfleisch; Ronald D. Chervin
STUDY OBJECTIVE This cohort study examined the impact of maternal snoring on key delivery outcomes such as mode of delivery, infant birth centile, and small-for-gestational age. DESIGN Cohort study. SETTING A large tertiary medical center. PATIENTS OR PARTICIPANTS Pregnant women in their third trimester were recruited between March 2007 and December 2010. MEASUREMENTS AND RESULTS Women were screened for habitual snoring, as a known marker for sleep disordered breathing. Outcome data were obtained from medical records following delivery and birth centiles were calculated. Of 1,673 women, a total of 35% reported habitual snoring (26% with pregnancy-onset snoring and 9% with chronic snoring). After adjusting for confounders, chronic snoring was associated with small-forgestational age (OR 1.65, 95%CI 1.02-2.66, P = 0.041) and elective cesarean delivery (OR 2.25, 95%CI 1.22-4.18, P = 0.008). Pregnancy-onset snoring was associated with emergency cesarean delivery (OR 1.68, 95%CI 1.22-2.30, P = 0.001). CONCLUSION Maternal snoring during pregnancy is a risk factor for adverse delivery outcomes including cesarean delivery and small-for-gestational age. Screening pregnant women for symptoms of SDB may provide an early opportunity to identify women at risk of poor delivery outcomes. CLINICAL TRIALS REGISTRATION IDENTIFIER: NCT01030003.
British Journal of Obstetrics and Gynaecology | 2014
L. M. O'Brien; Alexandra S. Bullough; Mark C. Chames; Anita Valanju Shelgikar; Roseanne Armitage; C. Guilleminualt; Colin E. Sullivan; T. R.B. Johnson; Ronald D. Chervin
To assess the frequency of obstructive sleep apnoea among women with and without hypertensive disorders of pregnancy.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | 2012
Louise O'Brien; Alexandra S. Bullough; Anita Valanju Shelgikar; Mark C. Chames; Roseanne Armitage; Ronald D. Chervin
STUDY OBJECTIVES To determine the relationships between key variables obtained from ambulatory polysomnography (PSG) and the wrist-worn Watch-PAT 200 device in pregnant women. METHODS In this prospective cohort study, women in their third trimester of pregnancy underwent full overnight home PSG using the 22-channel MediPalm system and the Watch-PAT 200 device. PSGs were scored by a blinded, experienced technologist using AASM 2007 criteria; the Watch-PAT was scored automatically by the manufacturers proprietary software. RESULTS A total of 31 pregnant women were studied. Mean age was 30.2 ± 7.1 years; mean gestational age was 33.4 ± 3.0 weeks; mean BMI was 31.9 ± 8.1 kg/m(2); 39% of women were nulliparous. Key variables generated by PSG and Watch-PAT correlated well over a wide range, including the apnea-hypopnea index (AHI, r = 0.76, p < 0.001); respiratory disturbance index (RDI, r = 0.68, p < 0.001), mean oxygen saturation (r = 0.94, p < 0.001), and minimum oxygen saturation (r = 0.88, p < 0.001). The area under the curve for AHI ≥ 5 and RDI ≥ 10 were 0.96 and 0.94, respectively. Association between stage 3 sleep on PSG and deep sleep on Watch-PAT was poor. Watch-PAT tended to overscore RDI, particularly as severity increased. CONCLUSIONS Among pregnant women, Watch-PAT demonstrates excellent sensitivity and specificity for identification of obstructive sleep apnea, defined as AHI ≥ 5 on full PSG. Watch-PAT may overestimate RDI somewhat, especially at high RDI values.
Clinical Obstetrics and Gynecology | 2010
Pamela Andreatta; Alexandra S. Bullough; David Marzano
The use of simulation-based methods for clinical and team training provides an opportunity for health care professionals to develop and maintain the skills required to effectively manage patient care. This is especially true for those rare events when emergency interventions require urgent, accurate, and cohesive team functioning. We present a framework for considering simulation-based training, examine contextual factors and the outcomes of research conducted to date in this area, and provide suggestions for selecting simulation-based approaches for developing obstetrics and gynecology teams in multiple contexts.
American Journal of Obstetrics and Gynecology | 2011
Pamela Andreatta; Jennifer Frankel; Sara Boblick Smith; Alexandra S. Bullough; David Marzano
The objective of this study was to evaluate the impact of an interdisciplinary team-training program in obstetric emergencies on identifying unsupportive institutional policies and systems-based practices. We implemented a qualitative study design with a purposive sample of interdisciplinary physicians, nurses, and ancillary allied health professionals from 4 specialties (n = 79) to conduct a 6-month, weekly simulation-based intervention for managing obstetric emergencies. Debriefing focused on identifying discrepancies between clinical practice and institutional policies. Our data yielded 5 categories of discrepancies between institutional or departmental policy and actual clinical practice. Specific institutional policies and system-based practices were recommended to health system administration for reevaluation. Simulation-based interdisciplinary team training can inform system-wide quality improvement objectives that could lead to increased patient safety.
Journal of Clinical Sleep Medicine | 2017
Galit Levi Dunietz; Lynda D. Lisabeth; Kerby Shedden; Q. Afifa Shamim-Uzzaman; Alexandra S. Bullough; Mark C. Chames; Marc F. Bowden; Louise O'Brien
STUDY OBJECTIVES To estimate the association of restless legs syndrome (RLS) and its frequency with sleep-wake disturbances in pregnancy. METHODS A cohort of 1,563 women in their third trimester of pregnancy were recruited from prenatal clinics between March 2007 and December 2010. Demographic, pregnancy, and delivery data were extracted from medical records and sleep information was collected with questionnaires. To diagnose RLS, we used standardized criteria of RLS symptoms and frequency that were developed by the International Restless Legs Study Group. Logistic regression models were constructed to investigate the association of RLS and its frequency with sleep-wake disturbances (poor sleep quality, daytime sleepiness, poor daytime function) and delivery outcomes. RESULTS Overall 36% of the pregnant women had RLS, and half had moderate to severe symptoms. Compared to women without RLS, those with RLS were more likely to have poor sleep quality (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.7-2.9), poor daytime function (OR 1.9, 95% CI 1.4-2.4), and excessive daytime sleepiness (OR 1.6, 95% CI 1.3-2.0). A dose-response relationship also was evident between RLS frequency and each of the sleep-wake disturbances. There was no evidence for any association between RLS and delivery outcomes. CONCLUSIONS RLS is a significant contributor to poor sleep quality, daytime sleepiness, and poor daytime function, all common and often debilitating conditions in pregnancy. Obstetric health care providers should be aware of these associations and screen women for RLS. COMMENTARY A commentary on this article appears in this issue on page 857.
Anesthesia & Analgesia | 2007
Olubukola O. Nafiu; Alexandra S. Bullough
Obstetrics & Gynecology | 2017
Jared Hooks; Cynthia Brincat; Sarah A. Wagner; Alexandra S. Bullough
Archive | 2012
Alexandra S. Bullough; Karen Wilkins