Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Alexandra Tabakin is active.

Publication


Featured researches published by Alexandra Tabakin.


PLOS Genetics | 2013

Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2

Piya Ghose; Eun Chan Park; Alexandra Tabakin; Nathaly Salazar-Vasquez; Christopher Rongo

Many aerobic organisms encounter oxygen-deprived environments and thus must have adaptive mechanisms to survive such stress. It is important to understand how mitochondria respond to oxygen deprivation given the critical role they play in using oxygen to generate cellular energy. Here we examine mitochondrial stress response in C. elegans, which adapt to extreme oxygen deprivation (anoxia, less than 0.1% oxygen) by entering into a reversible suspended animation state of locomotory arrest. We show that neuronal mitochondria undergo DRP-1-dependent fission in response to anoxia and undergo refusion upon reoxygenation. The hypoxia response pathway, including EGL-9 and HIF-1, is not required for anoxia-induced fission, but does regulate mitochondrial reconstitution during reoxygenation. Mutants for egl-9 exhibit a rapid refusion of mitochondria and a rapid behavioral recovery from suspended animation during reoxygenation; both phenotypes require HIF-1. Mitochondria are significantly larger in egl-9 mutants after reoxygenation, a phenotype similar to stress-induced mitochondria hyperfusion (SIMH). Anoxia results in mitochondrial oxidative stress, and the oxidative response factor SKN-1/Nrf is required for both rapid mitochondrial refusion and rapid behavioral recovery during reoxygenation. In response to anoxia, SKN-1 promotes the expression of the mitochondrial resident protein Stomatin-like 1 (STL-1), which helps facilitate mitochondrial dynamics following anoxia. Our results suggest the existence of a conserved anoxic stress response involving changes in mitochondrial fission and fusion.


Investigative and Clinical Urology | 2016

Open versus robotic cystectomy: Comparison of outcomes

Rachel Davis; Nicholas J. Farber; Alexandra Tabakin; Isaac Yi Kim; Sammy E. Elsamra

Open radical cystectomy (ORC) is the current gold standard treatment for muscle invasive bladder cancer. As surgeons become more proficient in minimally invasive and robotic surgical techniques, the number of patients undergoing robotic-assisted radical cystectomy (RARC) is increasing. Although minimally invasive methods are on the rise, research that critically compares open surgery with robotic methods is limited. In this review, we surveyed and appraised the current literature comparing ORC and RARC with regards to perioperative, functional, and oncologic outcomes in order to distinguish the benefits and disadvantages of each method. Here we report that RARC is associated with several perioperative advantages over ORC such as lower estimated blood loss and transfusion rate, and possibly faster gastrointestinal recovery, lower narcotic requirement, and shorter length of stay. ORC is less costly and permits less time in the operating room. Recent data suggests that there is no difference between ORC and RARC when comparing urinary continence and postoperative quality of life. Moreover, ORC and RARC are both associated with similar rates of obtaining positive surgical margins, lymph node yield, and recurrence. However, RARC patients had an increased likelihood of having distant metastases to extrapelvic lymph nodes and the peritoneum. At this point, it is unclear if ORC or RARC has superior patient outcomes, and more research is needed to ascertain management-altering conclusions.


Urology | 2018

Polypoid endometriosis presenting as a renal cortical tumor

Alexandra Tabakin; John L. Dutton; Aisha Fatima; Evita T. Sadimin; Thomas L. Jang

A 41-year-old female patient presented with left-sided flank pain and gross hematuria temporally unrelated to her menstrual cycle. Abdominal computed tomography scan showed a large left-sided solid, enhancing kidney mass radiographically consistent with renal cell carcinoma. Following surgical resection, histopathological examination revealed polypoid endometriosis. Polypoid endometriosis is rare and mimics a neoplasm clinically, radiographically, and on gross examination. Patients with polypoid endometriosis often present with symptoms related to mass effect rather than classic endometriosis hallmark symptoms such as dyspareunia, dysmenorrhea, and cyclic abdominal pain. Treatment includes surgical resection.


Journal of Clinical Urology | 2018

Effect of alvimopan on gastrointestinal recovery and length of hospital stay after retroperitoneal lymph node dissection for testicular cancer

Kushan Radadia; Nicholas J. Farber; Alexandra Tabakin; Wei Wang; Hiren V. Patel; Charles F. Polotti; Robert E. Weiss; Sammy E. Elsamra; Isaac Yi Kim; Eric A. Singer; Mark N. Stein; Tina M. Mayer; Thomas L. Jang

Objective: Alvimopan use has reduced the length of hospital stay in patients undergoing major abdominal surgeries and radical cystectomy. Retroperitoneal lymph node dissection for testicular cancer may be associated with delayed gastrointestinal recovery prolonging hospital length of stay. We evaluate whether alvimopan is associated with enhanced gastrointestinal recovery and shorter hospital length of stay in men undergoing retroperitoneal lymph node dissection for testicular cancer. Materials and methods: From 2010 to 2016, 29 patients underwent open, transperitoneal bilateral template retroperitoneal lymph node dissection. Data for patients who received alvimopan were prospectively collected and compared to a historical cohort of patients who did not receive alvimopan. Primary outcome measures were length of stay and recovery of gastrointestinal function. Descriptive statistics were reported. Time-to-event outcomes were evaluated using cumulative incidence curves and log rank test. Factors associated with length of stay were analyzed for correlation using multiple linear regression. Results: Of 29 men undergoing retroperitoneal lymph node dissection, eight received alvimopan and 21 did not. The two cohorts were well matched, with no significant differences. In the alvimopan cohort compared with those who did not receive alvimopan median time to return of flatus was 2 versus 4 days (p=0.0002), and median time to first bowel movement was 2.5 versus 5 days (p=0.046), respectively. Median length of stay in the alvimopan cohort was 4 days versus 6 days in those who did not receive alvimopan (p=0.074). In adjusted analyses, receipt of alvimopan did not influence length of stay. Conclusion: Alvimopan may facilitate gastrointestinal recovery after retroperitoneal lymph node dissection for testicular cancer. Whether this translates into reduced length of stay needs to be determined by randomized controlled trials using larger cohorts. Level of evidence: 3b.


The Journal of Urology | 2017

MP04-05 DECLINING USE OF CONTINENT DIVERSIONS FOR BLADDER CANCER

Nicholas Farber; Izak Faiena; Viktor Y. Dombrovskiy; Alexandra Tabakin; Brian Shinder; Rutveej Patel; Sammy Elsamra; Thomas L. Jang; Eric A. Singer; Robert M. Weiss

INTRODUCTION AND OBJECTIVES: The effect of non-muscle invasive bladder cancer (NMIBC) on health-related quality of life (HRQOL) is poorly understood. We evaluated changes in HRQOL in patients with a new diagnosis of NMIBC compared with the general population using the Surveillance Epidemiology and End Results (SEER) Medicare Health Outcomes Survey (MHOS) database. METHODS: We identified 325 Medicare beneficiaries diagnosed with NMIBC between initial and 2-year follow-up using SEERMHOS data (1998-2013). NMIBC patients who underwent cystoscopy with biopsy or transurethral resection of bladder tumor(s) for bladder cancer were propensity matched 1:5 to non-cancer controls (n1⁄41685). Changes from baseline in the physical component score (PCS) and mental component score (MCS), which are normalized to between 0-100, where 50 represents the US population mean, were compared between NMIBC patients and non-cancer controls with c testing and multivariate linear regression analysis. We secondarily assessed differences in urinary symptoms on post-diagnosis surveys with univariate and multivariate models. RESULTS: Pre-diagnosis, mean PCS (39.94 vs 39.54, p 1⁄4 0.71) and mean MCS (52.03 vs 52.17, p 1⁄4 0.82) scores were similar between NMIBC patients and matched non-cancer controls. Postdiagnosis, NMIBC patients had a significantly greater decrease in PCS compared with controls (-2.87 (95% CI -3.87, -1.86) vs. -1.47 (95% CI -1.93, -1.02), p 1⁄4 0.02). Conversely, mean MCS change did not vary between groups (-1.79 (95% CI -2.76, -0.81) vs. -0.72 (95% CI -1.21, -0.23), p 1⁄4 0.09). With respect to urinary function, NMIBC pts were more likely to have worsening of urinary leakage (38.0 % vs 18.7 %, p1⁄4 < 0.01), require physician intervention for urinary symptoms (33.9 % vs 13.7 %, p1⁄4 <0.01 ), and receive treatment for urine leakage (31.6 % vs 12.0 %, p1⁄4 <0.01 ) compared with non-cancer controls (p 1⁄4 <0.01). CONCLUSIONS: The diagnosis of NMIBC is associated with a significant decrease in physical HRQOL, including a significant impact on urinary symptoms and leakage. Further efforts to prospectively evaluate HRQOL in patients with NMIBC should be pursued to inform and improve patient counseling.


Bladder Cancer | 2018

Disparities in the Use of Continent Urinary Diversions after Radical Cystectomy for Bladder Cancer

Nicholas J. Farber; Izak Faiena; Viktor Y. Dombrovskiy; Alexandra Tabakin; Brian Shinder; Rutveej Patel; Sammy E. Elsamra; Thomas L. Jang; Eric A. Singer; Robert E. Weiss


The Journal of Urology | 2018

MP84-12 OUTCOMES AND FACTORS ASSOCIATED WITH RECEIPT OF OPEN VS MINIMALLY INVASIVE RETROPERITONEAL LYMPH NODE DISSECTION (RPLND) FOR TESTIS CANCER: ANALYZING THE NATIONAL CANCER DATABASE (NCDB) FROM 2010-2014

Alexandra Tabakin; Sinae Kim; Charles F. Polotti; Zorimar Rivera-Núñez; Joshua Sterling; Parth Modi; Nicholas Farber; Kushan Radadia; Rahul R. Parikh; Sharad Goyal; Robert E. Weiss; Isaac Yi Kim; Sammy Elsamra; Eric A. Singer; Thomas L. Jang


The Journal of Urology | 2017

MP80-04 EFFECT OF ALVIMOPAN ON GASTROINTESTINAL RECOVERY AND HOSPITAL LENGTH OF STAY AFTER RETROPERITONEAL LYMPH NODE DISSECTION FOR TESTICULAR CANCER

Kushan Radadia; Nicholas Farber; Alexandra Tabakin; Wei Wang; Lee Milas; Thomas L. Jang


Journal of Clinical Oncology | 2017

Effect of alvimopan on gastrointestinal recovery and length of hospitalization after retroperitoneal lymph node dissection for testicular cancer.

Kushan Radadia; Nicholas Farber; Alexandra Tabakin; Lee Milas; Thomas L. Jang


The Journal of Urology | 2016

MP12-17 ADRENALECTOMY FOR BENIGN AND MALIGNANT DISEASE: A POPULATION-BASED STUDY ON UTILIZATION AND OUTCOMES FROM 2003-2013

Izak Faiena; Alexandra Tabakin; Jeffrey J. Leow; Neal Patel; Parth Modi; Amirali Hassanzadeh Salmasi; Benjamin I. Chung; Steven D. Chang; Eric A. Singer

Collaboration


Dive into the Alexandra Tabakin's collaboration.

Top Co-Authors

Avatar

Thomas L. Jang

Memorial Sloan Kettering Cancer Center

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Parth Modi

Northwestern University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge