Alexandros Manolakos

Design and performance of noncoherent massive SIMO systems

A system with a single antenna transmitter and a large number of antennas at the receiver is considered. For this system we propose a simple noncoherent communication scheme based on energy detection that does not require knowledge of instantaneous channel state information at either the transmitter or the receiver. We also propose a constellation design based on the minimum distance criterion for this system and present numerical results to demonstrate the performance of this scheme for representative fading and noise statistics. Moreover, we show that this constellation design has the same scaling law performance as a system with perfect channel knowledge at the receiver.

Reference based genome compression

DNA sequencing technology has advanced to a point where storage is becoming the central bottleneck in the acquisition and mining of more data. Large amounts of data are vital for genomics research, and generic compression tools, while viable, cannot offer the same savings as approaches tuned to inherent biological properties. We propose an algorithm to compress a target genome given a known reference genome. The proposed algorithm first generates a mapping from the reference to the target genome, and then compresses this mapping with an entropy coder. As an illustration of the performance: applying our algorithm to James Watsons genome with hg18 as a reference, we are able to reduce the 2991 megabyte (MB) genome down to 6.99 MB, while Gzip compresses it to 834.8 MB.

CSI is not needed for optimal scaling in multiuser massive SIMO systems

An uplink system with a fixed number of single antenna transmitters and a single receiver with a large number of antennas is considered. For this system we propose an energy-based noncoherent communication scheme that does not use instantaneous channel state information at either the transmitter or the receiver: only the channel and noise statistics are used.We show that, in terms of the scaling law of achievable symmetric rates for two users, our schemes performance is no different from that achievable with perfect CSI (channel state information) at the transmitters and the receiver. We also provide a simple constellation design using the design criterion of minimum distance and present numerical results on how these designs perform in non-asymptotic regimes with typical channel and noise statistics.

CaMoDi: a new method for cancer module discovery.

BackgroundIdentification of genomic patterns in tumors is an important problem, which would enable the community to understand and extend effective therapies across the current tissue-based tumor boundaries. With this in mind, in this work we develop a robust and fast algorithm to discover cancer driver genes using an unsupervised clustering of similarly expressed genes across cancer patients. Specifically, we introduce CaMoDi, a new method for module discovery which demonstrates superior performance across a number of computational and statistical metrics.ResultsThe proposed algorithm CaMoDi demonstrates effective statistical performance compared to the state of the art, and is algorithmically simple and scalable - which makes it suitable for tissue-independent genomic characterization of individual tumors as well as groups of tumors. We perform an extensive comparative study between CaMoDi and two previously developed methods (CONEXIC and AMARETTO), across 11 individual tumors and 8 combinations of tumors from The Cancer Genome Atlas. We demonstrate that CaMoDi is able to discover modules with better average consistency and homogeneity, with similar or better adjusted R2 performance compared to CONEXIC and AMARETTO.ConclusionsWe present a novel method for Cancer Module Discovery, CaMoDi, and demonstrate through extensive simulations on the TCGA Pan-Cancer dataset that it achieves comparable or better performance than that of CONEXIC and AMARETTO, while achieving an order-of-magnitude improvement in computational run time compared to the other methods.

Blind null-space tracking for MIMO underlay cognitive radio networks

Blind Null Space Learning (BNSL) has recently been proposed for fast and accurate learning of the null-space associated with the channel matrix between a secondary transmitter and a primary receiver. In this paper we propose a channel tracking enhancement of the algorithm, namely the Blind Null Space Tracking (BNST) algorithm that allows transmission of information to the Secondary Receiver (SR) while simultaneously learning the null-space of the time-varying target channel. Specifically, the enhanced algorithm initially performs a BNSL sweep in order to acquire the null space. Then, it performs modified Jacobi rotations such that the induced interference to the primary receiver is kept lower than a given threshold

Scaling Laws for Noncoherent Energy-Based Communications in the SIMO MAC

P_{Th}

Null space learning in cooperative MIMO cellular networks using interference feedback

with probability

A Cross-Layer-Based Topology Control Framework for Wireless Multihop Networks

p

Energy-Based Modulation for Noncoherent Massive SIMO Systems

while information is transmitted to the SR simultaneously. We present simulation results indicating that the proposed approach has strictly better performance over the BNSL algorithm for channels with independent Rayleigh fading with a small Doppler frequency.

Interference due to null space mismatch in cooperative multipoint MIMO cellular networks

We consider a one-shot communication setting in which several single antenna transmitters communicate with a receiver with a large number of antennas, i.e., the receiver decodes transmitted information at the end of every symbol time. Motivated by the optimal noncoherent detector in a Rayleigh fading channel, we consider a noncoherent energy-based communication scheme that does not require any knowledge of instantaneous channel state information at either the transmitter or the receiver; it uses only the statistics of the channel and noise. We show that, for general channel fading statistics, the performance of the considered one-shot multiuser noncoherent scheme is the same, in a scaling law sense, as that of the optimal coherent scheme exploiting perfect channel knowledge and coding across time. Furthermore, we present a numerical evaluation of the performance of this scheme in representative fading and noise statistics.