Alexey V. Eliseev
Moscow State University
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Featured researches published by Alexey V. Eliseev.
Proceedings of the National Academy of Sciences of the United States of America | 2002
Matthias Hochgürtel; Heiko Kroth; Dorothea Piecha; Michael Hofmann; Claude Nicolau; Sonja Krause; Otmar Schaaf; Gabriele Sonnenmoser; Alexey V. Eliseev
Neuraminidase, a key enzyme responsible for influenza virus propagation, has been used as a template for selective synthesis of small subsets of its own inhibitors from theoretically highly diverse dynamic combinatorial libraries. We show that the library building blocks, aldehydes and amines, form significant amounts of the library components resulting from their coupling by reductive amination only in the presence of the enzyme. The target amplifies the best hits at least 120-fold. The dynamic libraries synthesized and screened in such an in vitro virtual mode form the components that possess high inhibitory activity, as confirmed by enzyme assays with independently synthesized individual compounds.
Journal of The Chemical Society-perkin Transactions 1 | 1991
Anatoly K. Yatsimirsky; Alexey V. Eliseev
Binding constants of a series of 4-substituted pyrocatechols (1,2-dihydroxybenzenes) to four 6-deoxy, 6-amino derivatives of β-cyclodextrin have been determined from the kinetics of their auto-oxidation at pH 10.0. In several cases, the binding constants at pH 6.0 have been determined by spectrophotometry. Cationic forms of amino derivatives of β-cyclodextrin bind pyrocatecholate anions with equilibrium constants up to 105 dm3 mol–1. The electrostatic and hydrophobic interactions were shown to contribute additively to the free energy of the host–guest complexation.
Polyhedron | 1989
Alexander D. Ryabov; Alexey V. Eliseev; Ekaterina S. Sergeyenko; Alexander V. Usatov; Leonid I. Zakharkin; V. N. Kalinin
1-Diphenylphosphinomethyl-o-carborane, o-HCB10H1OCCH2PPh2 (DPMC), reacts with Na2PdCl4 (methanol) or PdCl2(PhCN)2 (benzene) to give the “bis-adduct” trans- [PdCl2(DPMC)2], which on thermolysis in n-propanol transforms into the five-membered PdPCCB palladacycle, di-μ-chlorobis[(1-diphenylphosphinomethyl-o-carboranyl-B,P)palladium(II)] (IIa), as a mixture of B(3) and B(4) metallated isomers according to 1H and 31P NMR. If the internal palladation is performed in the presence of LiBr or NaI, the corresponding bromo- or iodo-bridged dimers are obtained. Complex IIa can also be prepared via ligand exchange in carboxylic acid solvents. In particular, palladium(II) migrates from cyclopalladated chloro-bridged N,N-dimethylbenzylamine or 1C-diphenylphosphino-o-carborane, i.e. from complexes with C,N-five- and B,P-four-membered palladacycles, respectively, to 1-diphenylphosphinomethyl-o -carborane yielding IIa. Migration of palladium(II) is also observed from the compounds with great stability towards acetic acid, namely the [PdCl(η3-allyl)]2 dimers. No such processes except with this particular ligand were found in the case of palladium(II) allyls and other entering ligands (azobenzene, 2-phenylpyridine, α-methylstyrene). The exchange processes described clearly show that complex IIa is characterized by a remarkable thermodynamic stability in acetic acid which accounts for the course of many exchange reactions.
Journal of The Chemical Society-perkin Transactions 1 | 1997
Marina I. Nelen; Alexey V. Eliseev
Complexation of six organic dianionic hosts (1cc–2tt) with methylguanidinium, tetramethylammonium and ammonium salts in various protic solvents has been studied by NMR spectroscopy. Stability of the 1∶1 electrostatic complexes is shown to decrease with increasing distances between the carboxylate groups in the host compounds. Spectroscopic data and the results of molecular modelling support non-symmetrical structures of some of the complexes which contain one tight and one loose ion pair. The difference between the contributions of the tight and loose ion pair formation into the binding free energy can be predicted by the Fuoss theory of ion pairing on the basis of interionic distances calculated by molecular modelling.
Journal of the American Chemical Society | 1997
Alexey V. Eliseev; Marina I. Nelen
Journal of Medicinal Chemistry | 2003
Matthias Hochgürtel; Ralf Biesinger; Heiko Kroth; Dorothea Piecha; Michael Hofmann; Sonja Krause; Otmar Schaaf; Claude Nicolau; Alexey V. Eliseev
Journal of The Chemical Society-perkin Transactions 1 | 1996
Volker Rüdiger; Alexey V. Eliseev; Svetlana Simova; Hans-Jörg Schneider; Michael J. Blandamer; Andrew Meyer
Journal of the American Chemical Society | 2000
Noureddin Nazarpack-Kandlousy; Igor Chernushevich; Lingjie Meng; Ying Yang; Alexey V. Eliseev
Organic Letters | 2000
Arthur Cho; Karen Ochoa Lara; Anatoly K. Yatsimirsky; Alexey V. Eliseev
Archive | 2002
Christoph Steeneck; Alexey V. Eliseev; Matthias Hochguertel; Heiko Kroth