Alexis Le Faucheur

Measurement of Walking Distance and Speed in Patients With Peripheral Arterial Disease A Novel Method Using a Global Positioning System

Background— The maximal walking distance (MWD) performed on a treadmill test remains the “gold standard” in estimating the walking capacity of patients who have peripheral arterial disease with intermittent claudication, although treadmills are not accessible to most physicians. We hypothesized that global positioning system (GPS) recordings could monitor community-based outdoor walking and provide valid information on walking capacity in patients with peripheral arterial disease. Methods and Results— We studied 24 patients (6 women) with arterial claudication (median [25th to 75th percentile] values: 57 years old [48 to 67 years], 169 cm tall [164 to 172 cm], weight 81 kg [71 to 86 kg], and ankle-brachial index 0.64 [0.56 to 0.74]). MWD on the treadmill was 184 m (144 to 246 m), which was compared with the results of self-reported MWD, the distance score from the Walking Impairment Questionnaire, MWD observed during a 6-minute walking test, and MWD measured over a GPS-recorded unconstrained outdoor walk in a public park. Self-reported MWD, Walking Impairment Questionnaire distance score, 6-minute walking test score, and GPS-measured MWD were 300 m (163 to 500 m), 28% (15% to 47%), 405 m (338 to 441 m), and 609 m (283 to 1287 m), respectively. The best correlation with MWD on the treadmill test was obtained with the MWD measured by the GPS (Spearman r=0.81, P<0.001). Conclusions— Outdoor walking capacity measured by a low-cost GPS is a potentially innovative way to study the walking capacity of patients with peripheral arterial disease. It opens new perspectives in the study of walking capacity for vascular patients with claudication under free-living conditions or for physicians who do not have a treadmill.

Variability and short-term determinants of walking capacity in patients with intermittent claudication

OBJECTIVE Global positioning system (GPS) recordings can provide valid information on walking capacity in patients with peripheral arterial disease (PAD) and intermittent claudication (IC) during community-based outdoor walking. This study used GPS to determine the variability of the free-living walking distance between two stops (WDBS), induced by lower-limb pain, which may exist within a single stroll in PAD patients with IC and the potential associated parameters obtained from GPS analysis. METHODS This cross-sectional study of 57 PAD patients with IC was conducted in a university hospital. The intervention was a 1-hour free-living walking in a flat public park with GPS recording at 0.5 Hz. GPS-computed parameters for each patient were WDBS, previous stop duration (PSD), cumulated time from the beginning of the stroll, and average walking speed for each walking bout. The coefficient of variation of each parameter was calculated for patients with the number of walking bouts (N(WB)) >or=5 during their stroll. A multivariate analysis was performed to correlate WDBS with the other parameters. RESULTS Mean (SD) maximal individual WDBS was 1905 (1189) vs 550 (621) meters for patients with N(WB) <5 vs N(WB) >or= 5, respectively (P < .001). In the 36 patients with N(WB) >or= 5, the coefficient of variation for individual WDBS was 43%. Only PSD and cumulated time were statistically associated with WDBS in 16 and 5 patients, respectively. CONCLUSIONS A wide short-term variability of WDBS exists and likely contributes to the difficulties experienced by patients with IC to estimate their maximal walking distance at leisurely pace. Incomplete recovery from a preceding walk, as estimated through PSD, seems to dominantly account for the WDBS in patients with IC.

Feasibility and validity of self-reported walking capacity in patients with intermittent claudication

OBJECTIVE The primary aim of this study was to assess if self-reported measures of walking limitation correlate better with a community-based assessment of maximum walking distance (MWD) than they do with laboratory-based tests in patients with intermittent claudication. A secondary aim was to examine the effect of prior objective testing on these correlations. METHODS Thirty-one patients completed three self-report tools (self-reported MWD; Walking Impairment Questionnaire [WIQ]; Estimation of Ambulatory Capacity by History-Questionnaire [EACH-Q]) immediately before and approximately 1 week after a series of objective tests (incremental treadmill walking test, 6-minute walk test, 1-hour global positioning system [GPS] recording of a community walk). We analyzed the feasibility of the self-report tools in terms of number of errors and their correlation (r) with objective measures. RESULTS The correlations of self-report tests to GPS-MWD (range, .579-.808) were consistently higher than with the treadmill test (range, .310-.584) and 6-minute walk test (range, .414-.613). The WIQ had the highest proportion of errors, both at first and second completion (58% and 42%, respectively), compared with self-reported MWD (23% and 13%, respectively) and the EACH-Q (6.5% and 13%, respectively). Correlations were improved with the second set of self-report tests (range, .310-.595 to .414-.808). CONCLUSIONS The fact that all self-report tools correlated better with a community-based measure of MWD using GPS than with laboratory results confirms that they measure what they aim to: community-based MWD. In addition, prescription of a community walk might help patients to better estimate their walking limitation.

The Accuracy of a Simple, Low-Cost GPS Data Logger/Receiver to Study Outdoor Human Walking in View of Health and Clinical Studies

Introduction Accurate and objective measurements of physical activity and lower-extremity function are important in health and disease monitoring, particularly given the current epidemic of chronic diseases and their related functional impairment. Purpose The aim of the present study was to determine the accuracy of a handy (lightweight, small, only one stop/start button) and low-cost (∼

Endofibrosis in athletes: is a simple bedside exercise helpful or sufficient for the diagnosis?

75 with its external antenna) Global Positioning System (GPS) data logger/receiver (the DG100) as a tool to study outdoor human walking in perspective of health and clinical research studies. Methods. Healthy subjects performed two experiments that consisted of different prescribed outdoor walking protocols. Experiment 1. We studied the accuracy of the DG100 for detecting bouts of walking and resting. Experiment 2. We studied the accuracy of the DG100 for estimating distances and speeds of walking. Results Experiment 1. The performance in the detection of bouts, expressed as the percentage of walking and resting bouts that were correctly detected, was 92.4% [95% Confidence Interval: 90.6–94.3]. Experiment 2. The coefficients of variation [95% Confidence Interval] for the accuracy of estimating the distances and speeds of walking were low: 3.1% [2.9–3.3] and 2.8% [2.6–3.1], respectively. Conclusion The DG100 produces acceptable accuracy both in detecting bouts of walking and resting and in estimating distances and speeds of walking during the detected walking bouts. However, before we can confirm that the DG100 can be used to study walking with respect to health and clinical studies, the inter- and intra-DG100 variability should be studied. Trial Registration ClinicalTrials.gov NCT00485147

The inter-and intra-unit variability of a low-cost GPS data logger/receiver to study human outdoor walking in view of health and clinical studies

Objective:Ankle-to-brachial index (ABI) can be easily performed by all physicians. The Ruffier-Dickson (RD) test is an easy procedure to attain moderate exercise at the bedside for physicians who do not have an ergometer. Design:Retrospective analysis. Setting:Tertiary care, institutional practice. Patients:Fifty-three asymptomatic athletes and 22 patients suffering from unilateral pain due to histologically proven exercise-induced arterial endofibrosis (EIAE). Intervention:Brachial and ankle systolic blood pressures were measured in the supine position on the suspected leg in EIAE or left leg in controls, at rest (rest) and at the first minute of the recovery from incremental maximal cycle ergometer exercise (maxCE) and Ruffier-Dickson (RD) exercise tests. Main Outcome Measures:Comparison of ABIrest, ABImaxCE, and ABIRD in discriminating patients from normal subjects, using receiver operating characteristics (ROC) curves. Results:Area (±SE of area) of ROC curve was 0.76 ± 0.06 for ABIrest, 0.83 ± 0.05 for ABIRD (nonsignificant from rest), and 0.99 ± 0.01 for ABImaxCE (P < 0.01 from ABIRD and P < 0.001 from ABIrest). An ABImaxCE below 0.48 was 100% specific and 80% sensitive for EIAE. For the RD test, a 100% negative predictive value was only attained for postexercise ABI values higher than 0.92. Conclusion:ABI after maximal cycle ergometer exercise is more accurate than ABI after an RD test to search for unilateral EIAE in athletes.

Exercise transcutaneous oxygen pressure measurement has good sensitivity and specificity to detect lower extremity arterial stenosis assessed by computed tomography angiography.

Purpose The present study evaluates the intra- and inter-unit variability of the GlobalSat® DG100 GPS data logger/receiver (DG100) when estimating outdoor walking distances and speeds. Methods Two experiments were performed using healthy subjects walking on a 400 m outdoor synthetic track. The two experiments consisted of two different outdoor prescribed walking protocols with distances ranging from 50 to 400 m. Experiment 1 examined the intra-unit variability of the DG100 (test-retest reproducibility) when estimating walking distances. Experiment 2 examined the inter-unit variability of four DG100 devices (unit to unit variability) when estimating walking distances and speeds. Results The coefficient of variation [95% confidence interval], for the reliability of estimating walking distances, was 2.8 [2.5–3.2] %. The inter-unit variability among the four DG100 units tested ranged from 2.8 [2.5–3.2] % to 3.9 [3.5–4.4] % when estimating distances and from 2.7 [2.4–3.0] % to 3.8 [3.4–4.2] % when estimating speeds. Conclusion The present study indicates that the DG100, an economical and convenient GPS data logger/receiver, can be reliably used to study human outdoor walking activities in unobstructed conditions. This device let facilitate the use of GPS in studies of health and disease.

Global Positioning System Use in the Community to Evaluate Improvements in Walking After Revascularization A Prospective Multicenter Study With 6-Month Follow-Up in Patients With Peripheral Arterial Disease

AbstractPeripheral artery disease (PAD) is a highly prevalent disease diagnosed by the use of ankle-brachial index (ABI) at rest. In some clinical conditions (diabetes, renal insufficiency, advanced age), ABI can be falsely normal and other tests are required for the PAD diagnosis (American Heart Association statement). This study was conducted to determine the accuracy of exercise transcutaneous oxygen pressure measurement (exercise-TcPo2) in detection of arterial stenosis ≥50% using computed tomography angiography (CTA) as the gold standard.We retrospectively analyzed consecutive patients referred to our vascular unit (University Hospital, Rennes, France) for exercise-TcPo2 testing from 2014 to 2015. All included patients had a CTA performed within 3 months of the exercise-TcPo2 test. Exercise-TcPo2 was performed on treadmill (10% slope; 2 mph speed). We calculated the Delta from Resting Oxygen Pressure (DROP) index (expressed in mm Hg) at the proximal and distal levels. Two blinded physicians performed stenosis quantification on CTA. The receiver operating characteristic (ROC) curve was used to define a cutoff point to detect arterial stenosis ≥50%, stenosis ≥60%, and stenosis ≥70%.A total of 34 patients (mean age 64 ± 2 years old; 74% men) were analyzed. The highest areas under the curve (AUC) were found for 60% stenosis at both proximal and distal levels. For stenosis ≥50%, sensitivity and specificity of proximal minimal DROP were 80.9% [67.1–89.7], 81.0% [59.3–92.7] respectively. For stenosis ≥50%, sensitivity and specificity of distal minimal DROP were 73.2% [60.3–83.1], 83.3% [53.8–96.2], respectively. For stenosis ≥60%, sensitivity and specificity of proximal minimal DROP were 82.5% [67.6–91.5] and 85.7% [67.7–94.8] respectively. For stenosis ≥60%, sensitivity and specificity of distal minimal DROP were 80.4% [67.3–89.1] and 88.2% [64.2–97.7], respectively. For stenosis ≥70%, sensitivity and specificity of proximal minimal DROP were 85.7% [67.7–94.8] and 75.0% [59.6–85.9] respectively. For stenosis ≥70%, sensitivity and specificity of distal minimal DROP were 86.0% [72.2–93.7] and 76.0% [56.1–88.7], respectively.Exercise-TcPo2 using a proximal minimal DROP value ⩽−15 mm Hg or a distal minimal DROP value ⩽−16 mm Hg is accurate to diagnose arterial stenosis especially stenosis ≥60% on the lower limbs. Exercise-TcPo2 is safe and noninvasive test that might be used in second line for PAD diagnosis.

Accuracy of a low-cost global positioning system receiver for estimating grade during outdoor walking

AbstractRevascularization aims at improving walking ability in patients with arterial claudication. The highest measured distance between 2 stops (highest-MDCW), the average walking speed (average-WSCW), and the average stop duration (average-DSCW) can be measured by global positioning system, but their evolution after revascularization is unknown.We included 251 peripheral artery diseased patients with self-reported limiting claudication. The patients performed a 1-hour stroll, recorded by a global positioning system receiver. Patients (n = 172) with confirmed limitation (highest-MDCW <2000m) at inclusion were reevaluated after 6 months. Patients revascularized during the follow-up period were compared with reference patients (ie, with unchanged lifestyle medical or surgical status). Other patients (lost to follow-up or treatment change) were excluded (n = 89).We studied 44 revascularized and 39 reference patients. Changes in highest-MDCW (+442 vs. +13 m) and average-WSCW (+0.3 vs. −0.2 km h−1) were greater in revascularized than in reference patients (both P < 0.01). In contrast, no significant difference in average-DSCW changes was found between the groups. Among the revascularized patients, 13 (29.5%) had a change in average-WSCW, but not in highest-MDCW, greater than the mean + 1 standard deviation of the change observed for reference patients.Revascularization may improve highest-MDCW and/or average-WSCW. This first report of changes in community walking ability in revascularized patients suggests that, beyond measuring walking distances, average-WSCW measurement is essential to monitor these changes. Applicability to other surgical populations remains to be evaluated.Registration: http://www.clinicaltrials.gov/ct2/show/NCT01141361

Predicting metabolic rate during level and uphill outdoor walking using a low-cost GPS receiver

The aim of this study was to assess, for the first time, the accuracy of a low-cost global positioning system (GPS) receiver for estimating grade during outdoor walking. Thirty subjects completed outdoor walks (2.0, 3.5 and 5.0 km · h-1) in three randomized conditions: 1/level walking on a 0.0% grade; 2/graded (uphill and downhill) walking on a 3.4% grade; and 3/on a 10.4% grade. Subjects were equipped with a GPS receiver (DG100, GlobalSat Technology Corp., Taiwan; ~US