Ali A. Khodadoust

Spontaneous regression of retinoblastoma

Clinicopathologic evidence of bilateral spontaneous regression of retinoblastoma in three brothers is presented. The buphthalmic right eye and phthisical left eye of one of these persons were examined histopathologically. The two brothers of this patient both had phthisical left eyes, and those eyes were examined histopathologically. Both of those brothers also had clinically detected chorioretinal scars in their right eyes from regressed retinoblastoma. Three of eight children of one of the two brothers had bilateral retinoblastoma, and two of seven children of the other brother had bilateral retinoblastoma. Reports in the literature of 50 previous cases of total spontaneous regression of retinoblastoma from 1911 to 1975 are reviewed.

Transfer of Bacterial Infection By Donor Cornea in Penetrating Keratoplasty

A 45-year-old man died of Hogdkins disease complicated by peritonitis and possible septicemia. His corneas were used for transplant in a 26-year-old man with advanced keratoconus and a 42-year-old man with vascularized central leukoma of old herpetic keratitis. Both recipients developed a fulminating endophthalmitis with Pseudomonas aeruginosa. We believe that the donor corneas, although clinically normal, were heavily infected, with signs of inflammation possibly suppressed by the Hodgkins disease.

The Fate of Corneal Regrafts after Previous Rejection Reactions

The prognosis for a clear corneal regraft is usually considered hopeless. However, it is not clear whether it is a poor recipient bed, technical difficulties, or the immune reaction which is the most important determining factor in the outcome of these grafts.