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Dive into the research topics where Ali Cenk Özay is active.

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Featured researches published by Ali Cenk Özay.


Gynecological Endocrinology | 2016

Role of kisspeptin in polycystic ovary syndrome (PCOS)

Ozlen Emekci Ozay; Ali Cenk Özay; Berrin Acar; Erkan Cagliyan; Mustafa Secil; Tuncay Kume

Abstract Objective: Due to the complex relationship between kisspeptin and the hypothalamic-pituitary-gonadal axis, the study was planned to measure the kisspeptin levels in polycystic ovary syndrome (PCOS) and to analyze the correlations between kisspeptin and PCOS-related reproductive, metabolic changes. Methods: The study was designed as a prospective study in Dokuz Eylul University between December 2011 and September 2013. A total of 285 PCOS cases and 162 controls were recruited. After the antropometric measeruments and physcial examination, blood samples were taken for biochemical analysis. Results: PCOS group’s mean BMI was 24.32 ± 3.40 and for the control group, BMI value was 23.44 kg/m2 ± 4.08 (p = 0.351). PCOS patients’ FSH level was 5.10 ± 2.01 mIU/L, LH value was 7.75 ± 4.31 mIU/mL, LH/FSH ratio was 1.70 ± 1.28, DHEAS value was 221.84 ± 105.02 mg/dl, total testosterone value was 50.51 ± 27.93 ng/ml, free testosterone value was 2.52 ± 1.05 pg/ml, SHBG was 63.74 ± 45.62 nmol/L, LDL was 102.56 ± 23.45 mg/dL, HDL value was 51.36 ± 12.15 mg/dL, total cholesterol value was 214.85 ± 39.27 mg/dL, triglyceride value was 112.95 ± 46.88 mg/dL, Apo A1 value was 171.30 ± 35.35 mg/dL, Apo B value was 71.08 ± 19.07 mg/dL, Apo B/A1 ratio was 0.42 ± 0.14, free androgen index was 13.77 ± 14.15, fasting glucose value was 80.68 ± 13.80 mg/dL, fasting insulin levels was 14.13 ± 9.11 μiU/mL, HOMA-IR index was 2.76 ± 2.34, AMH value was 5.93 ± 3:33 in ng/ml, and found to be significantly higher (p < 0.001). Leptin value was 9.71 ± 5.54 pg/ml and kisspeptin value was 1.92 ± 1.29 ng/ml, respectively. Kisspeptin and leptin levels showed no statistically significant difference with control group and PCOS group. In all PCOS patients, kisspeptin showed positive correlations between LH and leptin levels. Conclusion: In this study, kisspeptin had a positive correlation with LH and leptin levels in PCOS. In fact, the serum levels of kisspeptin and leptin does not differ statistically between PCOS and healthy women. There are limited data in the literature with regard to changes in kisspeptin levels and its relation with metabolic and hormonal disturbances.


International Journal of Gynecology & Obstetrics | 2016

Evaluation of thyroid function status among postmenopausal women with and without osteoporosis

Berrin Acar; Ali Cenk Özay; Ozlen Emekci Ozay; Emre Okyay; Ali Riza Sisman; Dinç Özaksoy

To investigate the relationship between thyroid function status and bone mineral density (BMD) among women with postmenopausal osteoporosis.


International Journal of Endocrinology | 2016

Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women

Ali Cenk Özay; Ozlen Emekci Ozay; Recep Emre Okyay; Erkan Cagliyan; Tuncay Kume; Bülent Gülekli

Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC). We aimed to examine myo-ins effects on anti-Mullerian hormone (AMH) levels and compare them with those ones obtained administering COC. In this prospective study, 137 PCOS patients, diagnosed according to Rotterdam criteria and admitted to the Reproductive Endocrinology and Infertility Outpatient Clinic at Dokuz Eylul University (Izmir, Turkey), were included. After randomization to COC (n = 60) and myo-ins (n = 77) arms, anthropometric measurements, blood pressure, Modified Ferriman Gallwey scores were calculated. Biochemical and hormonal analysis were performed, and LH/FSH and Apo B/A1 ratios were calculated. Data analysis was carried out in demographically and clinically matched 106 patients (COC = 54; myo-ins = 52). After 3-month treatment, increase in HDL and decreases in LH and LH/FSH ratio were statistically more significant only in COC group when compared with baseline (in both cases p > 0.05). In myo-ins group, fasting glucose, LDL, DHEAS, total cholesterol, and prolactin levels decreased significantly (for all p < 0.05). Progesterone and AMH levels, ovarian volume, ovarian antral follicle, and total antral follicle counts lessened significantly in both groups (for all p < 0.05). In PCOS treatment, MYO is observed more effective in reductions of total ovarian volume and AMH levels.


Gynecological Endocrinology | 2017

Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial

Ozlen Emekci Ozay; Ali Cenk Özay; Erkan Cagliyan; Recep Emre Okyay; Bülent Gülekli

Abstract Objectıve: The aim of the study is to investigate the effect of myo-inositol (MYO) on pregnancy rates of patients diagnosed with polycystic ovary syndrome (PCOS) who undergone controlled ovulation induction and intrauterine insemination (IUI). Methods: A total of 196 infertile patients diagnosed with PCOS and admitted to Dokuz Eylul University Faculty of Medicine were included in the study between March 2013 and May 2016. The patients in group 1 (n = 98) were given 4 g MYO and 400 μg folic acid before and during ovulation induction. The patients undergone controlled ovarian hyperstimulation (COH) with recombinant FSH and IUI. The patients in group 2 (n = 98), were given recombinant FSH directly and 400 μg folic acid. The primary outcome measure of this study was the clinical pregnancy rate. Results: In group 1, 9 patients conceived spontaneous pregnancy. During COH + IUI treatment three cycles were canceled in group 1 and 8 cycles in group 2. Total rFSH dose and cycle duration were significantly lower and clinical pregnancy rates were higher in group 1. The pregnancy rate for group 1 was %18.6 and for group 2 was %12.2. Conclusıons: This study shows that MYO should be considered in the treatment of infertile PCOS patients. MYO administration increases clinical pregnancy rates, lowers total rFSH dose and the duration of the ovulation induction.


International Journal of Endocrinology | 2018

Corrigendum to “Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women”

Ali Cenk Özay; Ozlen Emekci Ozay; Recep Emre Okyay; Erkan Cagliyan; Tuncay Kume; Bülent Gülekli

[This corrects the article DOI: 10.1155/2016/3206872.].


Gynecology Obstetrics and Reproductive Medicine | 2016

A Case of Pregnancy Complicated by the Development of a Tubo-Ovarian Abscess Following an Aspiration of Endometrioma During Oocyte Pick up

Recep Emre Okyay; Ali Cenk Özay; Özlen Emekçi; Ali Rıza Taylan Bodur; Ömer Erbil Doğan


Archive | 2016

Uterin Arter Embilozasyonu Sonrasi Myoma Uterinin Ekspulsiyonu: Olgu sunumu Expulsion of A Uterin Myoma After Uterin Artery Embolization: Case Report ZKTB

Olgu Sunumu; Ali Cenk Özay; Özlen Emekçi; Berrin Acar; Aygün Akberova


Journal of Clinical Obstetrics, Gynecology & Infertility | 2016

Follicular Variant of Papillary Thyroid Carcinoma Arising in a Mature Cystic Teratoma of the Ovary

Özlen Emekçi; Ali Cenk Özay; Meral Koyuncuoglu; Abdurrahman Comlekci; Berrin Acar


Gynecology Obstetrics and Reproductive Medicine | 2016

Management of Ectopic Pregnancy: Comparison of Systemic Methotrexate Administration and Surgical Treatment; A Retrospective Study

Ali Cenk Özay; Özlen Emekçi; Recep Emre Okyay; Ali Rıza Taylan Bodur


Zeynep Kamil Tıp Bülteni | 2015

Uterin arter embilozasyonu sonrası myoma uterinin ekspulsiyonu: olgu sunumu

Ali Cenk Özay; Özlen Emekçi; Berrin Acar; Aygün Akberova; Aslı Akdöner

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Berrin Acar

Dokuz Eylül University

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Tuncay Kume

Dokuz Eylül University

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