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Dive into the research topics where Ali Fassih is active.

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Featured researches published by Ali Fassih.


Experimental Cell Research | 2014

Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway

Nina Tandon; Elisa Cimetta; Aranzazu Villasante; Nicolette Kupferstein; Michael Southall; Ali Fassih; Junxia Xie; Ying Sun; Gordana Vunjak-Novakovic

Electrical signals have been implied in many biological mechanisms, including wound healing, which has been associated with transient electrical currents not present in intact skin. One method to generate electrical signals similar to those naturally occurring in wounds is by supplementation of galvanic particles dispersed in a cream or gel. We constructed a three-layered model of skin consisting of human dermal fibroblasts in hydrogel (mimic of dermis), a hydrogel barrier layer (mimic of epidermis) and galvanic microparticles in hydrogel (mimic of a cream containing galvanic particles applied to skin). Using this model, we investigated the effects of the properties and amounts of Cu/Zn galvanic particles on adult human dermal fibroblasts in terms of the speed of wound closing and gene expression. The collected data suggest that the effects on wound closing are due to the ROS-mediated enhancement of fibroblast migration, which is in turn mediated by the BMP/SMAD signaling pathway. These results imply that topical low-grade electric currents via microparticles could enhance wound healing.


Lasers in Surgery and Medicine | 2018

Low-level red LED light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne: RED LIGHT DELIVERS ACNE-RELEVANT BENEFITS IN VITRO

Wen-Hwa Li; Ali Fassih; Curt Binner; Ramine Parsa; Michael Southall

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of Propionibacterium acnes (P. acnes), and increased inflammatory mediator release. Light therapy has attracted medical interests as a safe alternative treatment for acne. Both blue and red light therapies at high doses >10 J/cm2 have demonstrated marked effects on inflammatory acne lesions. However, few studies have investigated the effects of lower doses of light. The aim of this study is to investigate the biological effects of lower doses of red light at 0.2–1.2 J/cm2 for acne using an in vitro model previously developed to mimic the inflammation and hyperkeratinization observed clinically in acne.


Archive | 2010

Galvanic skin treatment device

Ali Fassih; Ronald J. Gillespie; Jue-Chen Liu; Chong Jin Loy; Claude Saliou; Ying Sun


Archive | 2009

Treatment of sweating and hyperhidrosis

Ali Fassih; Jeannette Chantalat; Jue-Chen Liu; Joan D. Newburger; Ying Sun


Archive | 2008

Treatment of hyperhydrosis

Ali Fassih; Ronald J. Gillespie; Michael Joyce; Joseph Junio; Joan D. Newburger; Ying Sun


Archive | 2013

Anhydrous Powder-to-Liquid Particles

Ali Fassih; Ying Sun


Archive | 2015

COMPOSITIONS AND METHODS FOR ENHANCING THE TOPICAL APPLICATION OF A BENEFIT AGENT INCLUDING POWDER TO LIQUID PARTICLES AND A SECOND POWDER

Ali Fassih; Loy Chong Jin; Michael Southall; Ying Sun


Archive | 2014

COMPOSTIONS AND METHODS FOR ENHANCING THE TOPICAL APPLICATION OF A BASIC BENEFIT AGENT

Ying Sun; Jeffrey M. Wu; Ali Fassih


Archive | 2017

aplicação tópica de composições para a pele tendo baixo ph

Ali Fassih; Anne-Sophie Brillouet; Devin L. Garcia; Dianne Rossetti; Janet Wangari-Talbot; Jyotsna Paturi; Marisa Devita Dufort; Ramine Parsa; Robert Wayne Yates; Wen-Hwa Ting Li; Yaping Hu; Ying Sun


Archive | 2017

composições contendo enxofre polimérico e seus usos

Ali Fassih; Euen T. Ekman-Gunn; Kelly Dunn; Ramine Parsa; Wen-Hwa Li

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