Ali Fassih
Johnson & Johnson
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Publication
Featured researches published by Ali Fassih.
Experimental Cell Research | 2014
Nina Tandon; Elisa Cimetta; Aranzazu Villasante; Nicolette Kupferstein; Michael Southall; Ali Fassih; Junxia Xie; Ying Sun; Gordana Vunjak-Novakovic
Electrical signals have been implied in many biological mechanisms, including wound healing, which has been associated with transient electrical currents not present in intact skin. One method to generate electrical signals similar to those naturally occurring in wounds is by supplementation of galvanic particles dispersed in a cream or gel. We constructed a three-layered model of skin consisting of human dermal fibroblasts in hydrogel (mimic of dermis), a hydrogel barrier layer (mimic of epidermis) and galvanic microparticles in hydrogel (mimic of a cream containing galvanic particles applied to skin). Using this model, we investigated the effects of the properties and amounts of Cu/Zn galvanic particles on adult human dermal fibroblasts in terms of the speed of wound closing and gene expression. The collected data suggest that the effects on wound closing are due to the ROS-mediated enhancement of fibroblast migration, which is in turn mediated by the BMP/SMAD signaling pathway. These results imply that topical low-grade electric currents via microparticles could enhance wound healing.
Lasers in Surgery and Medicine | 2018
Wen-Hwa Li; Ali Fassih; Curt Binner; Ramine Parsa; Michael Southall
Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of Propionibacterium acnes (P. acnes), and increased inflammatory mediator release. Light therapy has attracted medical interests as a safe alternative treatment for acne. Both blue and red light therapies at high doses >10 J/cm2 have demonstrated marked effects on inflammatory acne lesions. However, few studies have investigated the effects of lower doses of light. The aim of this study is to investigate the biological effects of lower doses of red light at 0.2–1.2 J/cm2 for acne using an in vitro model previously developed to mimic the inflammation and hyperkeratinization observed clinically in acne.
Archive | 2010
Ali Fassih; Ronald J. Gillespie; Jue-Chen Liu; Chong Jin Loy; Claude Saliou; Ying Sun
Archive | 2009
Ali Fassih; Jeannette Chantalat; Jue-Chen Liu; Joan D. Newburger; Ying Sun
Archive | 2008
Ali Fassih; Ronald J. Gillespie; Michael Joyce; Joseph Junio; Joan D. Newburger; Ying Sun
Archive | 2013
Ali Fassih; Ying Sun
Archive | 2015
Ali Fassih; Loy Chong Jin; Michael Southall; Ying Sun
Archive | 2014
Ying Sun; Jeffrey M. Wu; Ali Fassih
Archive | 2017
Ali Fassih; Anne-Sophie Brillouet; Devin L. Garcia; Dianne Rossetti; Janet Wangari-Talbot; Jyotsna Paturi; Marisa Devita Dufort; Ramine Parsa; Robert Wayne Yates; Wen-Hwa Ting Li; Yaping Hu; Ying Sun
Archive | 2017
Ali Fassih; Euen T. Ekman-Gunn; Kelly Dunn; Ramine Parsa; Wen-Hwa Li