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Dive into the research topics where Ali Gholipour is active.

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Featured researches published by Ali Gholipour.


IEEE Transactions on Medical Imaging | 2007

Brain Functional Localization: A Survey of Image Registration Techniques

Ali Gholipour; Nasser Kehtarnavaz; Richard W. Briggs; Michael D. Devous; Kaundinya S. Gopinath

Functional localization is a concept which involves the application of a sequence of geometrical and statistical image processing operations in order to define the location of brain activity or to produce functional/parametric maps with respect to the brain structure or anatomy. Considering that functional brain images do not normally convey detailed structural information and, thus, do not present an anatomically specific localization of functional activity, various image registration techniques are introduced in the literature for the purpose of mapping functional activity into an anatomical image or a brain atlas. The problems addressed by these techniques differ depending on the application and the type of analysis, i.e., single-subject versus group analysis. Functional to anatomical brain image registration is the core part of functional localization in most applications and is accompanied by intersubject and subject-to-atlas registration for group analysis studies. Cortical surface registration and automatic brain labeling are some of the other tools towards establishing a fully automatic functional localization procedure. While several previous survey papers have reviewed and classified general-purpose medical image registration techniques, this paper provides an overview of brain functional localization along with a survey and classification of the image registration techniques related to this problem


IEEE Transactions on Medical Imaging | 2010

Robust Super-Resolution Volume Reconstruction From Slice Acquisitions: Application to Fetal Brain MRI

Ali Gholipour; Judy A. Estroff; Simon K. Warfield

Fast magnetic resonance imaging slice acquisition techniques such as single shot fast spin echo are routinely used in the presence of uncontrollable motion. These techniques are widely used for fetal magnetic resonance imaging (MRI) and MRI of moving subjects and organs. Although high-quality slices are frequently acquired by these techniques, inter-slice motion leads to severe motion artifacts that are apparent in out-of-plane views. Slice sequential acquisitions do not enable 3-D volume representation. In this study, we have developed a novel technique based on a slice acquisition model, which enables the reconstruction of a volumetric image from multiple-scan slice acquisitions. The super-resolution volume reconstruction is formulated as an inverse problem of finding the underlying structure generating the acquired slices. We have developed a robust M-estimation solution which minimizes a robust error norm function between the model-generated slices and the acquired slices. The accuracy and robustness of this novel technique has been quantitatively assessed through simulations with digital brain phantom images as well as high-resolution newborn images. We also report here successful application of our new technique for the reconstruction of volumetric fetal brain MRI from clinically acquired data.


Cerebral Cortex | 2013

Delayed Cortical Development in Fetuses with Complex Congenital Heart Disease

Cedric Clouchoux; A.J. du Plessis; Marine Bouyssi-Kobar; Wayne Tworetzky; Doff B. McElhinney; David W. Brown; Ali Gholipour; D. Kudelski; Simon K. Warfield; Robert McCarter; Richard L. Robertson; Alan C. Evans; Jane W. Newburger; Catherine Limperopoulos

Neurologic impairment is a major complication of complex congenital heart disease (CHD). A growing body of evidence suggests that neurologic dysfunction may be present in a significant proportion of this high-risk population in the early newborn period prior to surgical interventions. We recently provided the first evidence that brain growth impairment in fetuses with complex CHD has its origins in utero. Here, we extend these observations by characterizing global and regional brain development in fetuses with hypoplastic left heart syndrome (HLHS), one of the most severe forms of CHD. Using advanced magnetic resonance imaging techniques, we compared in vivo brain growth in 18 fetuses with HLHS and 30 control fetuses from 25.4-37.0 weeks of gestation. Our findings demonstrate a progressive third trimester fall-off in cortical gray and white matter volumes (P < 0.001), and subcortical gray matter (P < 0.05) in fetuses with HLHS. Significant delays in cortical gyrification were also evident in HLHS fetuses (P < 0.001). In the HLHS fetus, local cortical folding delays were detected as early as 25 weeks in the frontal, parietal, calcarine, temporal, and collateral regions and appear to precede volumetric brain growth disturbances, which may be an early marker of elevated risk for third trimester brain growth failure.


Medical Image Analysis | 2012

Super-resolution reconstruction to increase the spatial resolution of diffusion weighted images from orthogonal anisotropic acquisitions

Benoit Scherrer; Ali Gholipour; Simon K. Warfield

Diffusion-weighted imaging (DWI) enables non-invasive investigation and characterization of the white matter but suffers from a relatively poor spatial resolution. Increasing the spatial resolution in DWI is challenging with a single-shot EPI acquisition due to the decreased signal-to-noise ratio and T2(∗) relaxation effect amplified with increased echo time. In this work we propose a super-resolution reconstruction (SRR) technique based on the acquisition of multiple anisotropic orthogonal DWI scans. DWI scans acquired in different planes are not typically closely aligned due to the geometric distortion introduced by magnetic susceptibility differences in each phase-encoding direction. We compensate each scan for geometric distortion by acquisition of a dual echo gradient echo field map, providing an estimate of the field inhomogeneity. We address the problem of patient motion by aligning the volumes in both space and q-space. The SRR is formulated as a maximum a posteriori problem. It relies on a volume acquisition model which describes how the acquired scans are observations of an unknown high-resolution image which we aim to recover. Our model enables the introduction of image priors that exploit spatial homogeneity and enables regularized solutions. We detail our SRR optimization procedure and report experiments including numerical simulations, synthetic SRR and real world SRR. In particular, we demonstrate that combining distortion compensation and SRR provides better results than acquisition of a single isotropic scan for the same acquisition duration time. Importantly, SRR enables DWI with resolution beyond the scanner hardware limitations. This work provides the first evidence that SRR, which employs conventional single shot EPI techniques, enables resolution enhancement in DWI, and may dramatically impact the role of DWI in both neuroscience and clinical applications.


NeuroImage | 2012

Multi-Atlas Multi-Shape Segmentation of Fetal Brain MRI for Volumetric and Morphometric Analysis of Ventriculomegaly

Ali Gholipour; Alireza Akhondi-Asl; Judy A. Estroff; Simon K. Warfield

The recent development of motion robust super-resolution fetal brain MRI holds out the potential for dramatic new advances in volumetric and morphometric analysis. Volumetric analysis based on volumetric and morphometric biomarkers of the developing fetal brain must include segmentation. Automatic segmentation of fetal brain MRI is challenging, however, due to the highly variable size and shape of the developing brain; possible structural abnormalities; and the relatively poor resolution of fetal MRI scans. To overcome these limitations, we present a novel, constrained, multi-atlas, multi-shape automatic segmentation method that specifically addresses the challenge of segmenting multiple structures with similar intensity values in subjects with strong anatomic variability. Accordingly, we have applied this method to shape segmentation of normal, dilated, or fused lateral ventricles for quantitative analysis of ventriculomegaly (VM), which is a pivotal finding in the earliest stages of fetal brain development, and warrants further investigation. Utilizing these innovative techniques, we introduce novel volumetric and morphometric biomarkers of VM comparing these values to those that are generated by standard methods of VM analysis, i.e., by measuring the ventricular atrial diameter (AD) on manually selected sections of 2D ultrasound or 2D MRI. To this end, we studied 25 normal and abnormal fetuses in the gestation age (GA) range of 19 to 39 weeks (mean=28.26, stdev=6.56). This heterogeneous dataset was essentially used to 1) validate our segmentation method for normal and abnormal ventricles; and 2) show that the proposed biomarkers may provide improved detection of VM as compared to the AD measurement.


computer assisted radiology and surgery | 2011

Fetal brain volumetry through MRI volumetric reconstruction and segmentation.

Ali Gholipour; Judy A. Estroff; Carol E. Barnewolt; Susan A. Connolly; Simon K. Warfield

PurposeFetal MRI volumetry is a useful technique but it is limited by a dependency upon motion-free scans, tedious manual segmentation, and spatial inaccuracy due to thick-slice scans. An image processing pipeline that addresses these limitations was developed and tested.Materials and methodsThe principal sequences acquired in fetal MRI clinical practice are multiple orthogonal single-shot fast spin echo scans. State-of-the-art image processing techniques were used for inter-slice motion correction and super-resolution reconstruction of high-resolution volumetric images from these scans. The reconstructed volume images were processed with intensity non-uniformity correction and the fetal brain extracted by using supervised automated segmentation.ResultsReconstruction, segmentation and volumetry of the fetal brains for a cohort of twenty-five clinically acquired fetal MRI scans was done. Performance metrics for volume reconstruction, segmentation and volumetry were determined by comparing to manual tracings in five randomly chosen cases. Finally, analysis of the fetal brain and parenchymal volumes was performed based on the gestational age of the fetuses.ConclusionThe image processing pipeline developed in this study enables volume rendering and accurate fetal brain volumetry by addressing the limitations of current volumetry techniques, which include dependency on motion-free scans, manual segmentation, and inaccurate thick-slice interpolation.


international conference of the ieee engineering in medicine and biology society | 2008

Comparison of tissue segmentation algorithms in neuroimage analysis software tools

On Tsang; Ali Gholipour; Nasser Kehtarnavaz; Kaundinya S. Gopinath; Richard W. Briggs; Issa M. S. Panahi

Accurate segmentation of different brain tissues is of much importance in magnetic resonance imaging. This paper presents a comparison of the existing segmentation algorithms that are deployed in the neuroimaging community as part of two widely used software packages. The results obtained in this comparison can be used to select the appropriate segmentation algorithm for the neuroimaging application of interest. In addition to the entire brain area, a comparison is carried out for the subcortical region of the brain in terms of its gray matter composition.


IEEE Transactions on Medical Imaging | 2017

Auto-Context Convolutional Neural Network (Auto-Net) for Brain Extraction in Magnetic Resonance Imaging

Seyed Sadegh Mohseni Salehi; Deniz Erdogmus; Ali Gholipour

Brain extraction or whole brain segmentation is an important first step in many of the neuroimage analysis pipelines. The accuracy and the robustness of brain extraction, therefore, are crucial for the accuracy of the entire brain analysis process. The state-of-the-art brain extraction techniques rely heavily on the accuracy of alignment or registration between brain atlases and query brain anatomy, and/or make assumptions about the image geometry, and therefore have limited success when these assumptions do not hold or image registration fails. With the aim of designing an accurate, learning-based, geometry-independent, and registration-free brain extraction tool, in this paper, we present a technique based on an auto-context convolutional neural network (CNN), in which intrinsic local and global image features are learned through 2-D patches of different window sizes. We consider two different architectures: 1) a voxelwise approach based on three parallel 2-D convolutional pathways for three different directions (axial, coronal, and sagittal) that implicitly learn 3-D image information without the need for computationally expensive 3-D convolutions and 2) a fully convolutional network based on the U-net architecture. Posterior probability maps generated by the networks are used iteratively as context information along with the original image patches to learn the local shape and connectedness of the brain to extract it from non-brain tissue. The brain extraction results we have obtained from our CNNs are superior to the recently reported results in the literature on two publicly available benchmark data sets, namely, LPBA40 and OASIS, in which we obtained the Dice overlap coefficients of 97.73% and 97.62%, respectively. Significant improvement was achieved via our auto-context algorithm. Furthermore, we evaluated the performance of our algorithm in the challenging problem of extracting arbitrarily oriented fetal brains in reconstructed fetal brain magnetic resonance imaging (MRI) data sets. In this application, our voxelwise auto-context CNN performed much better than the other methods (Dice coefficient: 95.97%), where the other methods performed poorly due to the non-standard orientation and geometry of the fetal brain in MRI. Through training, our method can provide accurate brain extraction in challenging applications. This, in turn, may reduce the problems associated with image registration in segmentation tasks.


international conference of the ieee engineering in medicine and biology society | 2008

Average field map image template for Echo-Planar image analysis

Ali Gholipour; Nasser Kehtarnavaz; Kaundinya S. Gopinath; Richard W. Briggs; Issa M. S. Panahi

Magnetic resonance field map images are normally used in characterizing the magnetic field inhomogeneity for distortion correction in Echo-Planar Imaging (EPI) and accurate localization in functional MRI (fMRI). In this paper, the computation and applications of an average field map image template is investigated based on real field maps. The introduced methodology and the obtained field map image templates may be used in EPI and fMRI image analysis, distortion correction, registration, and functional localization when high-resolution field map images are not available for individual datasets. The introduced methodology involves three stages of pre-processing, registration, and spatial normalization. The analysis and results presented in this paper show the impact and usefulness of the investigated methodology in several applications.


IEEE Transactions on Biomedical Engineering | 2008

Validation of Non-Rigid Registration Between Functional and Anatomical Magnetic Resonance Brain Images

Ali Gholipour; Nasser Kehtarnavaz; Richard W. Briggs; Kaundinya S. Gopinath; Wendy Ringe; Anthony R. Whittemore; S. Cheshkov; Khamid Bakhadirov

This paper presents a set of validation procedures for nonrigid registration of functional EPI to anatomical MRI brain images. Although various registration techniques have been developed and validated for high-resolution anatomical MRI images, due to a lack of quantitative and qualitative validation procedures, the use of nonrigid registration between functional EPI and anatomical MRI images has not yet been deployed in neuroimaging studies. In this paper, the performance of a robust formulation of a nonrigid registration technique is evaluated in a quantitative manner based on simulated data and is further evaluated in a quantitative and qualitative manner based on in vivo data as compared to the commonly used rigid and affine registration techniques in the neuroimaging software packages. The nonrigid registration technique is formulated as a second-order constrained optimization problem using a free-form deformation model and mutual information similarity measure. Bound constraints, resolution level and cross-validation issues have been discussed to show the degree of accuracy and effectiveness of the nonrigid registration technique. The analyses performed reveal that the nonrigid approach provides a more accurate registration, in particular when the functional regions of interest lie in regions distorted by susceptibility artifacts.

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Simon K. Warfield

Boston Children's Hospital

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Nasser Kehtarnavaz

University of Texas at Dallas

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Judy A. Estroff

Boston Children's Hospital

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Kaundinya S. Gopinath

University of Texas Southwestern Medical Center

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Richard W. Briggs

University of Texas Southwestern Medical Center

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Benoit Scherrer

Boston Children's Hospital

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