Ali Güngör

Association of Van Wyk Grumbach and Debre Semelaigne Syndromes with Severe Hypothyroidism

BACKGROUND Van Wyk Grumbach syndrome (VWGS) and Kocher-Debre Semelaigne syndrome (KDSS) are rare forms of pseudo-precocious puberty and myopathy in patients with longstanding untreated hypothyroidism. We present the case of an adolescent girl who developed pseudo-precocious puberty and myopathy caused by long-term untreated hypothyroidism. CASE A 17-year-old female patient was referred to our outpatient clinic due to menstrual irregularities. She had muscle pain and multiple cystic ovaries in addition to clinical signs of severe congenital hypothyroidism. High levels of creatinine and creatinine kinase and accompanying muscle hypertrophy were present. After the initiation of L-thyroxine therapy, the symptoms were alleviated in a short time. CONCLUSION Congenital and acquired hypothyroidism should be considered in the differential diagnosis of pseudo-precocious puberty and myopathy that presents with muscle pain, muscle hypertrophy, and elevated creatinine kinase levels.

A Rarely Seen Dermatosis: Terra Firma-Forme Dermatosis

Terra firma-forme dermatosis (TFFD) is a keratinization disorder characterized by dirt-like brown hyperpigmented plaques. The diagnosis and treatment of this disease, the cause of which is not exactly known, is quite easy. The most important feature of the lesions that are mostly seen in the neck and body is that while they cannot be removed with water and soap, they can easily be removed with 70% isopropyl or ethyl alcohol. In this report, we present two pediatric cases diagnosed with TFFD.