Ali H. Bardy

Objectively measured tobacco exposure during pregnancy: neonatal effects and relation to maternal smoking

Objective To measure quantitatively and objectively the maternal and fetal tobacco exposure during pregnancy and its neonatal effects.

Obstetric outcome in women with epilepsy

A comparison of 150 pregnancies in women with epilepsy and 150 pregnancies in matched nonepileptic control women showed similar rates of pregnancy-induced hypertension, albuminuria, premature contractions, premature labor, and bleeding in pregnancy. Duration of labor, blood loss at delivery, cesarean section rates, and vacuum extraction rates were also similar among epileptic and control groups. There were five perinatal deaths in the epileptic group and two in the control group. A fetal heart rate tracing during a maternal grand mal seizure showed bradycardia, reduced short-term and long-term variability, and late decelerations suggesting asphyxia. It is concluded that grand mal seizures during pregnancy should be avoided by the use of antiepileptic drugs. Women with epilepsy require antenatal neurological and obstetric follow-up during pregnancy.

Monitoring of concentrations of clobazam and norclobazam in serum and saliva of children with epilepsy

Clobazam was added to the previous antiepileptic drug therapy of 90 children suffering from drug resistant epilepsy. Ten patients became seizure free, although four of these later developed tolerance. Thirty-three patients experienced a decrease in seizure frequency, and 24 of these, too, developed tolerance. Forty-four patients showed no change in seizure frequency, and three experienced an increase. The best results were experienced by patients with myoclonic seizures, whereas patients with complex partial seizures usually developed tolerance. The concentrations of clobazam and its active metabolite norclobazam were measured in 251 serum and 57 saliva samples. The group of seizure-free patients had the lowest clobazam and norclobazam concentrations; tolerance was associated with the highest concentrations. Beneficial side effects were associated with low, and adverse effects with high, concentrations of norclobazam. The concentrations of clobazam and norclobazam in saliva correlated with concentrations in serum. Monitoring of serum and salivary concentrations of clobazam and norclobazam is of limited value only, and no therapeutic target range can be given.

Serum phenytoin during pregnancy, labor and puerperium

111 pregnancies of epileptic women on phenytoin therapy were observed in a prospective study. Maternal serum phenytoin concentrations were measured monthly or biweekly during pregnancy, labor and puerperium. The concentration decreased towards the end of pregnancy and was lowest at delivery. In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency.

Decisions after first seizure

The probability of an intracerebral neoplasm occurring in patients presenting with first seizure was calculated using the data provided by four recent studies. After recording the history of the patients and performing clinical neurological examinations, the probability of a neoplasm was increased or reduced substantially, allowing rational decision to be made for further investigation or follow‐up. The impact of conventional EEG on the probabilities was weak. Decision analysis can be used to improve diagnostic practices.

Objectively measured perinatal exposure to meperidine and benzodiazepines in Finland

We measured concentrations of meperidine and benzodiazepines in the umbilical serum of all live neonates born in Finland during a single week. Of the neonates, 31.1% were exposed to meperidine or benzodiazepines or both. One hundred twenty‐one mothers of the 261 neonates exposed to meperidine were not recorded in the Finnish Medical Birth Registry as having received analgesic drugs. Infants born to primiparous mothers were more likely to be exposed. The exposures were associated with the type of delivery: vacuum extraction with a high proportion of neonates exposed to meperidine and elective caesarean section with a high proportion of neonates exposed to benzodiazepines. The exposures were influenced by the method of obstetric analgesia: epidural blockade was associated with more frequent exposure to meperidine. No significant circadian variation in exposures was detected. Validation of birth registry data is imperative before they are used for pharmacoepidemiologic studies.

Effect of pregnancy on the electroencephalogram of epileptic women

ABSTRACT‐ The electroencephalograms (EEGs) of epileptic women in late pregnancy were compared with their EEGs outside pregnancy and the puerperium. The number of epileptic interictal discharges was not modified by pregnancy. Visual scoring and frequency analysis demonstrated a slight increase in the alpha band during pregnancy. No correlations were found between the EEG findings and changes in seizure frequency.