Ali İrfan Güzel
Çukurova University
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Featured researches published by Ali İrfan Güzel.
Asian Pacific Journal of Cancer Prevention | 2014
Hasan Onur Topçu; Ali İrfan Güzel; İrfan Özer; Mahmut Kuntay Kokanalı; Umut Göktürk; Kamil Hakan Muftuoglu; Melike Doğanay
PURPOSE To compare the diagnostic accuracy of the neutrophil/lymphocyte ratio (NLR) with the platelet/lymphocyte ratio (PLR) in predicting malignancy of pelvic masses which are pre-operatively malignant suspicious. MATERIALS AND METHODS In this retrospective study we evaluated the clinical features of patients with ovarian masses which had pre-operatively been considered suspicious for malignancy. The patients whose intraoperative frozen sections were malign were classified as the study group, while those who had benign masses were the control group. Data recorded were age of the patient, diameter of the mass, pre-operative serum Ca 125 levels, platelet count, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. RESULTS There was statistically significantly difference between the groups in terms of age, diameter of the mass, serum Ca 125 levels, platelet number and platelet/lymphocyte ratio. Mean neutrophil/lymphocyte ratios showed no difference between the groups. ROC curve analysis showed that age, serum Ca 125 levels, platelet number and PLR were discriminative markers in predicting malignancy in adnexal masses. CONCLUSIONS According to the current study, serum Ca 125 levels, pre-operative platelet number and PLR may be good prognostic factors, while NLR is an ineffective marker in predicting the malignant characteristics of a pelvic mass.
European Journal of Obstetrics & Gynecology and Reproductive Biology | 2014
H.O. Topçu; Sabri Cavkaytar; K. Kokanalı; Ali İrfan Güzel; Mine Islimye; Melike Doğanay
OBJECTIVE To determine the effects of different intra-abdominal pressure values on visceral pain following gynecologic laparoscopic surgery in the Trendelenburg position. STUDY DESIGN This randomized, controlled prospective trial was conducted at a tertiary education hospital and included 150 patients who underwent gynecologic laparoscopy with different abdominal insufflation pressures. There were 54 patients in the 8 mmHg low pressure group (LPG), 45 in the 12 mmHg standard pressure group (SPG), and 51 in the 15 mmHg high pressure group (HPG). We assessed mean age, body mass index (BMI), duration of surgery, analgesic consumption, length of hospital stay, amount of CO2 expended and volume of hemorrhage. Visceral pain and referred visceral pain were assessed 6, 12, and 24 h postoperatively using a visual analog scale (VAS). RESULTS There was no significant difference in age, BMI, analgesic consumption or length of hospital stay among groups. The mean operative time and total CO2 expended during surgery were higher in the LPG compared with the SPG and HPG. The mean intensity of postoperative pain assessed by the VAS score at 6 and 12 h was less in the LPG than in the SPG and HPG and was reduced significantly at 12 h. VAS scores at 24 h in the LPG and SPG were lower than in the HPG. CONCLUSION Pain is reduced by low insufflation pressure compared with standard and high insufflation pressure following gynecologic laparoscopic surgery in the Trendelenburg position. However, low insufflation pressure may result in longer operation times and increased hemorrhage.
Asian Pacific Journal of Cancer Prevention | 2014
Ali İrfan Güzel; Mahmut Kuntay Kokanalı; Selçuk Erkılınç; Hasan Onur Topçu; Murat Oz; Emre Ozgu; Salim Erkaya; Tayfun Gungor
PURPOSE The objective of this study was to assess the predictive role of the neutrophil/lymphocyte ratio (NLR) for invasion of gestational trophoblastic disease (GTD). MATERIALS AND METHODS A retrospective analysis was conducted on 127 women who were managed at our clinic for GTD. Of all patients, 8 showed invasion according to histological examination. The clinical parameters of patients with invasive GTD (Group 1; n=8) were compared with patients who showed no invasion (Group 2; n=119). All underwent a prior uterine evacuation and followed up by regular assessment of β-hCG titers. RESULTS Demographic and obstetric history and pre-evacuation hCG levels of the patients showed no statistically significantly difference between the groups (p>0.05). The mean gestational weeks (GW), size of the GTD and NLR levels were statistically significantly higher in the invasive GTD group (p<0.05). Correlations between invasion and gestational weeks, size of GTD, post-evacuation chemotherapy and NLR were evident. ROC curve analysis demonstrated that GW, size of GTD and NLR may be discriminative parameters in predicting invasion of GTD. CONCLUSIONS To the best of our knowledge, this is the first study evaluating the predictive role of NLR in invasion of GTD. In conclusion, we think that pretreatment NLR can be used as a biomarker of invasion in GTD.
Journal of The Chinese Medical Association | 2014
Mahmut Kuntay Kokanalı; Sabri Cavkaytar; Ali İrfan Güzel; Hasan Onur Topçu; Elçin Eroğlu; Orhan Aksakal; Melike Doğanay
Background We aimed to determine if preprocedural anxiety levels had a significant association with procedure‐related pain in women undergoing office hysteroscopy (OH) and also to assess the effect of various clinical factors on pain perception in these women. Methods There were 148 women undergoing OH enrolled in this observational study. Before examination, patients were asked to complete two forms, the STAI‐T (State–Trait Anxiety Inventory, Trait) and STAI‐S (State‐Trait Anxiety Inventory, State) anxiety scales, to evaluate their usual anxiety state and state of anxiety during the examination. Patients were asked to quantify on a visual analog scale the pain felt during and 60 minutes after the procedure. Associations between STAI and visual analog scale scores were assessed using correlation analysis. The effects of various contributing factors on pain perception were investigated with linear regression analysis. A p value < 0.05 was considered statistically significant. Results The preprocedural mean trait and state anxiety scores were 38.4 ± 9.2 and 44.8 ± 10.0, respectively, and the mean patient age was 43.6 ± 3.3 years. During OH, there were significant positive correlations between in‐hospital waiting time, procedure time, preprocedural trait or state anxiety scores, and pain. Sixty minutes after OH, significant positive correlations between in‐hospital waiting time, procedure time, preprocedural state or trait anxiety scores, and pain were observed. There was also a significant negative correlation between parity and procedure‐related pain 60 minutes after procedure. OH‐related pain scores during the procedure were significantly affected by in‐hospital waiting time (p < 0.001), state anxiety level (p = 0.001), and trait anxiety level (p = 0.01). However, 60 minutes after the procedure, pain was affected by patient parity (p = 0.02), procedure time (p = 0.002), and preprocedural state anxiety level (p < 0.001). Conclusion The pain that study participants felt during and soon after OH was negatively affected by preprocedural anxiety levels. Some factors, such as reducing the waiting time before the procedure, might be useful in reducing anxiety levels.
Journal of Pediatric and Adolescent Gynecology | 2015
Ülker Gümüş; Ali İrfan Güzel; Hasan Onur Topçu; Hakan Timur; Nafiye Yilmaz; Nuri Danisman
STUDY OBJECTIVE We evaluated the plasma visfatin levels in hirsute female adolescents with polycystic ovary syndrome. DESIGN, SETTING, AND PARTICIPANTS This prospective case-control study included 87 female patients who were seen in our adolescence department. Demographic characteristics and hormonal and biochemical parameters were evaluated between patients with and without polycystic ovary syndrome. Next, we divided the patients with polycystic ovary syndrome into the following subgroups: overweight or obese (body mass index [BMI] ≥ 25 kg/m(2)) vs normal weight (BMI < 25 kg/m(2)) and hirsute vs nonhirsute. RESULTS There were statistically significant differences in the BMI, serum androgen levels, homeostasis model assessment-insulin resistance (HOMA-IR) levels, and insulin levels between patients with and without polycystic ovary syndrome (P < .05). The mean visfatin levels showed no statistically significant difference between these 2 groups (P > .05). The serum visfatin levels were similar between the 2 subgroups classified by BMI (P > .05). However, there were statistically significant differences in the total and free testosterone levels, 17-hydroxylase progesterone level, HOMA-IR level, and visfatin level between the 2 subgroups classified by hirsutism (P < .05). The plasma visfatin level was higher in hirsute PCOS than in nonhirsute PCOS patients. CONCLUSION Significantly higher visfatin levels were found in hirsute than in nonhirsute adolescents with PCOS. According to these results, plasma visfatin levels may be a useful marker in hirsute adolescents with PCOS.
Journal of Maternal-fetal & Neonatal Medicine | 2015
Ali Yeter; Hasan Onur Topçu; Ali İrfan Güzel; Emre Ozgu; Nuri Danisman
Abstract Objective: To investigate a possible correlation between maternal plasma homocysteine (HC) concentrations and intrauterine growth retardation (IUGR). Methods: The patients were divided into the IUGR group and controls. The IUGR group consisted of 40 women and their newborns with birth weight <the 10th percentile for gestational age, whereas 45 infants with birth weight ≥the 10th percentile comprised the control group. Blood samples were obtained from the antecubital vein within 24 h after the delivery. Results: No significant differences between the population characteristics in the two groups were found. There was a statistically significant difference in serum concentrations of HC: 5.6 ± 1.9 µmol/L in the IUGR group and 4.6 ± 1.2 µmol/L in controls (p = 0.01). ROC curve analysis demonstrated that pulsatility index (PI), resistance index (RI) and HC concentrations were discriminative markers in IUGR group. According to Pearson correlation analysis there was a possible association between HC concentrations and PI, RI and middle cerebral artery Doppler velocimetry (MCA). Conclusion: Higher maternal HC concentration and lower birth weight were observed in the IUGR group as compared to the control group. We are of the opinion that maternal plasma homocysteine concentration may be a prognostic marker in intrauterine growth retardation.
Genetic Testing and Molecular Biomarkers | 2009
Ali İrfan Güzel; Osman Demirhan; Ayfer Pazarbaşı; Fatma Tuncay Ozgünen; Sabriye Kocatürk-Sel; Deniz Taştemir
AIM To investigate parental origins and cell stage errors of a double nondisjunction in a fetus. METHOD For the determination of the most common chromosome anomalies, quantitative fluorescent polymerase chain reaction method using short tandem repeat (STR) DNA markers was applied to a fetus with abnormal ultrasonographic findings. Parental origin and cell stage errors of the trisomies were inferred by comparing the inherited STR alleles. Conventional cytogenetic technique was also applied for the confirmation of the aneuploidies. RESULTS A double nondisjunction including chromosomes 21 and X (48,XXX,+21) was detected prenatally in the fetus. The origin of both chromosomes was maternal, and the errors were in meiosis I for 21 and meiosis II for X. Molecular results were concordant with cytogenetic results. CONCLUSION Molecular techniques could be useful for the pre- and postnatal diagnosis of the common aneuploidies and determining its parental origin. This kind of study will improve knowledge about the mechanisms of nondisjunction and enable appropriate and rapid genetic counseling.
Female pelvic medicine & reconstructive surgery | 2015
Orhan Aksakal; Sabri Cavkaytar; Ali İrfan Güzel; Canan Uzun; Melike Doğanay
Urethral coitus in women with a normal vagina and introitus has very rarely been reported. We report the case of a 48-year-old gravida 5, para 5 woman with a history of urethral coitus complaining of urinary incontinence. To the best of our knowledge, our patient is the fifth reported case of urethral coitus with normal genitalia, and it might be accepted as the first reported case of urethral coitus in a multiparous woman.
Journal of Maternal-fetal & Neonatal Medicine | 2017
Hatice Kansu-Celik; Burcu Kisa Karakaya; Ali İrfan Güzel; Yasemin Tasci; Salim Erkaya
Abstract Objective: To evaluate the effect of pre-pregnancy body mass index on maternal and perinatal outcomes among adolescent pregnant women. Methods: We conducted this prospective cross-sectional study on 365 singleton adolescent pregnancies (aged between 16 and 20 years) at a Maternity Hospital, between December 2014 and March 2015. We divided participants into two groups based on pre-pregnancy body mass index (BMI): overweight and obese adolescent (BMI at or above 25.0 kg/m) and normal weight (BMI between 18.5 and 24.99 kg/m) adolescent. We used multivariate analysis to evaluate the association of the risk of adverse pregnancy outcomes and pre-pregnancy BMI. Results: The prevalence of maternal overweight/obesity and normal weight was 34.6% (n = 80) and 65.4% (n = 261) in the study population, respectively. Compared with normal-weight teens (n = 234), overweight/obese teens (n = 71) were at higher risk for cesarean delivery (odds ratio [OR] 0.7, 95% confidence interval [CI] 0.4–1.4), preeclampsia (adjusted odds ratio [OR] 0.1, 95% confidence interval [CI] 0.02–0.9) and small of gestational age (odds ratio [OR] 0.2, 95% confidence interval [CI] 0.1–0.9). Conclusion: BMI increased during pre-pregnancy could be an important preventable risk factor for poor obstetric complications in adolescent pregnancies, and for these patients prevention strategies (e.g., nutritional counseling, weight-loss, regular physical activity) for obesity are recommended before getting pregnant.
Journal of The Chinese Medical Association | 2016
Ali İrfan Güzel; Mehmet Çınar; Selçuk Erkılınç; Rıfat Taner Aksoy; Omer Hamid Yumusak; Fatma Celik; Yusuf Celik
Background To evaluate the maternal serum amino acid levels in first trimester adolescent pregnancies by using a new developed dietary questionnaire. Methods A group of 169 pregnant women in the first trimester of their pregnancy were asked to complete the dietary questionnaire. Among all the women, 39 were adolescent pregnancies. The results of the questionnaire were evaluated by a nutrient database program (BeBiS software program) designed to evaluate Turkish traditional foods and commercial processed foods. Results There was no statistically significant difference between the groups in terms of body mass index and educational and socio‐economic status. The mean age and gravidity was statistically significantly lower in adolescent pregnancies. The mean isoleucine, leucine, lysine, methionine, phenylalanine, tyrosine, threonine, valine, arginine, and proline levels were statistically significantly lower in adolescent pregnancies. Receiver operating characteristic (ROC) curve analysis showed the cut‐off values of these amino acids. Of these amino acids; lower values of histidine, serine, and alanine were associated with lower birth weight, and lower values of histidine and alanine were associated with preterm delivery. Conclusion To the best of our knowledge, this is the first study evaluating the amino acid levels in adolescent pregnancies. According to this study, some amino acid levels were lower in adolescent pregnancies and associated with adverse perinatal outcomes. Further studies with maternal and perinatal outcomes are needed to demonstrate the effects of these amino acids in such pregnancies.