Ali Kandeger

Relationships of neutrophil–lymphocyte and platelet–lymphocyte ratios with the severity of major depression

We aimed to evaluate the neutrophil-lymphocyte (NLR) and platelet-lymphocyte (PLR) ratios of inpatients and outpatients suffering from different levels of major depression. In total, 100 inpatients and 60 patients treated at an outpatient clinic were included the study. The presence of mood and anxiety disorders was identified with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/Clinical Version, and the Hamilton Depression Rating Scale was used to assess the severity of major depression (MD). Inpatients and outpatients with MD did not differ in NLR or PLR. The PLRs of patients who had severe major depression with psychotic features were higher than those of patients with other types of depression, but no differences in NLRs were detected across types of depression. The PLRs were higher in patients with severe levels of major depression with psychotic features than in other patients. This parameter may be more predictive than is NLR for assessing the prognosis of major depression.

The Effects of Individual Biological Rhythm Differences on Sleep Quality, Daytime Sleepiness, and Dissociative Experiences

Individuals who differ markedly by sleep chronotype, i.e., morning-type or evening-type also differ on a number of psychological, behavioral, and biological variables. Among several other psychological functions, dissociation may also lead to disruption and alteration of consciousness, which may facilitate dream-like experiences. Our study was aimed at an inquiry into the effects of individual biological rhythm differences on sleep quality and daytime sleepiness in conjunction with dissociative experiences. Participants were 372 undergraduate college students, completed a package of psychological instruments, including the Morningness-Eveningness Questionnaire, Dissociative Experiences Scale, Insomnia Severity Index, and Epworth Sleepiness Scale. Using logistic regression models, direct relations of pathological dissociation with sleepiness, sleep quality and circadian preferences were investigated. Poor sleep quality and sleepiness significantly contributed to the variance of dissociative symptomatology. Although there was no substantial linear association between circadian preferences and pathological dissociation, having evening-type preferences of sleep was indirectly associated with higher dissociation mediated by poor sleep quality. Poor sleep quality and daytime sleepiness seems to be significant antecedents of pathological dissociation. Sleep chronotype preferences underlie this relational pattern that chronobiological characteristics seem to influence indirectly on dissociative tendency via sleep quality.

Heterogeneity of sleep quality in relation to circadian preferences and depressive symptomatology among major depressive patients

BACKGROUND The current study aimed at investigating the latent dimensional structure of sleep quality as indexed by the seven components of the Pittsburgh Sleep Quality Index (PSQI), as well as latent covariance structure between sleep quality, circadian preferences and depressive symptoms. METHODS Two hundred twenty-five patients with major depressive disorder (MDD), with an average age of 29.92 ± 10.49 years (aged between 17 and 63), participated in the study. The PSQI, Morningness-Eveningness Questionnaire (MEQ) and Beck Depression Inventory (BDI) were administered to participants. Four sets of latent class analyses were subsequently run to obtain optimal number of latent classes best fit to the data. RESULTS Mixture models revealed that sleep quality is multifaceted in MDD. The data best fit to four-latent-class model: Poor Habitual Sleep Quality (PHSQ), Poor Subjective Sleep Quality (PSSQ), Intermediate Sleep Quality (ISQ), and Good Sleep Quality (GSQ). MDD patients classified into GSQ latent class (23.6%) reported the lowest depressive symptoms and were more prone to morningness diurnal preferences compared to other three homogenous sub-groups. Finally, the significant association between eveningness diurnal preferences and depressive symptomatology was significantly mediated by poor sleep quality. LIMITATION The cross-sectional nature of the study and the lack of an objective measurement of sleep such as polysomnography recordings was the most striking limitation of the study. CONCLUSIONS We concluded sleep quality in relation to circadian preferences and depressive symptoms has a heterogeneous nature in MDD.

The effects of biological rhythms and sleep quality on benign paroxysmal positional vertigo and reflux symptom severity

Abstract Recently, there has been increased interest in chronotypes and clinical differences between them. However, there is limited information about the potential influence of the chronotypes on clinical manifestations and symptom intensity of somatic diseases. The aim of this study is to evaluate the impact of biological rhythm differences and sleep quality on benign paroxysmal positional vertigo (BPPV) and larengo pharyngeal reflux (LPR) severity. Forty-four LPR patients, 43 BBPV patients and 42 controls were included in the study. The morningness–eveningness questionnaire was used to determine chronotypes, and the Pittsburgh Sleep Quality Index was used to assess subjective sleep quality. Both patient groups reported a significantly greater tendency to eveningness diurnal preferences compared to healthy controls. As with the circadian preferences, patients with BPPV or LPR characterized by poorer sleep quality and worse insomnia than non-patient individuals. It can be concluded that the circadian rhythm and sleep quality are related to the severity of LPR and BPPV.

Case of Klinefelter's Syndrome in an 18 Year Old Male Presented with Antisocial Personality Disorder

Case of Klinefelters syndrome in an 18 year old male presented with antisocial personality disorder Klinefelters syndrome (KS) is the most common chromosomal aberration among men and is associated with multiple psychiatric comorbidities. Individuals with KS have an increased prevalence of psychiatric disturbances, ranging from attention deficit and hyperactivity disorder (ADHD) in childhood to schizophrenia and severe affective disorders during adulthood. We want to present a case report of KS who presented with antisocial personality disorder and related disorders which are ADHD, conduct disorder and alcoholism. The common feature of all these disorders may be associated with X-linked chromosomes.

The effects of individual circadian rhythm differences on insomnia, impulsivity, and food addiction

PurposeIndividuals can generally be divided into morning, neither and evening types according to behavioral, psychological, and biological variables including appetite levels, usual meal times, sleep times, and melatonin secretion. These factors together identify a person as being part of a certain chronotype, i.e., as feeling more efficient either in the morning (morning type) or later in the day (evening type). Food addiction is defined as addictive behavior toward palatable foods and is thought to be one of the underlying risk factors for obesity. Our aim in this study was to investigate the relationship between circadian rhythm differences and food addiction via insomnia and impulsivity in university students.MethodParticipants were 1323 university students, filled out a package of psychological tools, including the Morningness–Eveningness Questionnaire, Insomnia Severity Index, Barratt Impulsiveness Scale Short Form, and Yale Food Addiction Scale. Logistic regression analysis was used to investigate direct relation of food addiction with insomnia, impulsivity and obesity, and mediation regression analysis was used to investigate the indirect effect of circadian rhythm differences on food addiction.ResultsOur findings indicated that evening types were more prone to insomnia and impulsivity, and also insomnia and impulsivity significantly contributed to the variance of food addiction. Although there was no significant linear relationship between circadian rhythm differences and food addiction, evening-type circadian preferences were indirectly associated with higher food addiction scores mediated by insomnia and impulsivity.ConclusionThe most remarkable result of our work was that circadian rhythm differences seem to indirectly effect on food addiction through elevated insomnia and impulsivity.Level of evidenceLevel V, descriptive cross-sectional survey.

Delusional misidentification syndromes: a case of intermetamorphosis

Intermetamorphosis is a phenomenon in which there is a marked increase in familiarity and the physical and mental identities of familiar or unfamiliar people change and become a familiar person to the patient. Intermetamorphosis is the rarest syndromes among SYTS and was termed by Courbon and Tusques in 1932. In this article, a case of intermetamorphosis syndrome in a patient diagnosed with schizophrenia will be presented.

Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats.

Objective The Western-type diet is associated with an elevated risk of Alzheimer’s disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n=16) and standard housing condition (n=24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid β-peptide (Aβ) (1–40), Aβ(1–42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results The EE decreased the Aβ(1–40), Aβ(1–42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion This observation shows that EE may rescue diet-induced amyloid and tau pathology.

Heterogenity of Sleep Quality in Relations Between Cirdadian Preferences and Depressive Symptomatology Among Major Depression Patients

Objective The effect of poor sleep quality on depressive symptoms has been consistently found. The aim of our study was to assess the heterogenity of sleep quality in relations between circadian preferences and depressive symptomatology among major depression patients. Method The sample was consisted of 225 patients with first diagnosis major depression. Mean age of the sample was 29.92 (SD±10.49). The patients completed a package of psychological instruments including the Morningness–Eveningness Questionnaire, Pittsburgh Sleep Quality Index, and Beck Depression Inventory. The latent structure of sleep quality among first diagnose major depressive patients was examined by applying latent class analysis (LCA) to the seven components of the PSQI, using Mplus 4.01. We also examined the latent structure of sleep quality in conjunction with the MEQ and BDI scores. Results We found that evening-type depressive patients were more prone to report greater scores of subjective sleep quality, sleep latency, sleep duration, use of sleep medication and daytime dysfunction sub-scales of the PSQI. Direct effect of evening-type chronobiological preference was significantly linked to greater depression scores. Indirect effects of chronobiological characteristics through components of the PSQI were only significant for use of sleep medication and daytime dysfunction sub-scales of the PSQI (p Discussion These findings suggest that sleep quality in general operates and influences on depression in concert with chronobiological characteristics; however, the construct of sleep quality appear like to be heterogeneous in nature and is influential on severity of depression symptoms through distinct mechanisms among depressive patients.

The Effects of Individual Biological Rhythm Differences On Sleep Quality, Daytime Sleepiness and Correlations with Dissociative Experiences

Objective Individuals who differ markedly by chronotype, i.e., morning-type or evening-type, differ on a number of psychological, behavioral, and biological variables. Disruption in the usually integrated functions of consciousness, memory, identity and perception is definitional to dissociation, particularly pathological forms of dissociation. Dissociative experiences possess dream-like properties, which might be fueled by a labile sleep-wake cycle. Our study aimed to investigate the effects of individual biological rhythm differences on sleep quality and daytime sleepiness in conjunction with dissociative experiences. Method Participants were 372 undergraduates, ranged between 18 and 26 years of age, 61.6 % were females. The volunteers completed a package of psychological instruments including the Morningness–Eveningness Questionnaire, Dissociative Experiences Scale, Insomnia Severity Index, and Epworth Sleepiness Scale. Results We performed mediation regression analysis of relations between dissociative symptomatology and chronobiological features mediated by insomnia and sleepiness. We run a multiple mediator model utilizing from the SPSS script in which we bootstrapped 5000 times. We found direct effect of the MEQ scores on the DES scores was not substantial. Direct effect of the MEQ on the ESS was not significant; whilst the direct association between the ESS and the DES was significant (β=0.79; p Discussion We found significant associations of pathological dissociation in terms of DES-taxon with insomnia and sleepiness.