Ali Kemal Kutlu
Trakya University
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Featured researches published by Ali Kemal Kutlu.
Case reports in pathology | 2011
Ebru Tastekin; Semsi Altaner; Cem Uzun; Ahmet Rifat Karasalihoglu; Cigdem Ozdemir; Ali Kemal Kutlu
Primary chondroid tumors of the larynx represent less than 1% of all laryngeal tumors. Most of them are chondromas and they often involve to the cricoid cartilage. A 31-year-old male patient applied to the oto-laryngology service with a history of dysphonia and dyspnea. Microlaryngoscopy revealed 2 cm sized, ill-defined, covered with regular mucosa, porous, and hard mass on posterior surface of crycoid cartilage in subglottic area. Following the excision of the lesion, histopathologic examination revealed as chondroma. Two years later, local recurrence was detected and the diagnosis was again chondroma. There was no complaint of the patient in last 3 and half years of follow-up. Chondroma should carefully be differentiated from chondrosarcoma and the patients should be followed for possible recurrences.
Turkish Journal of Pathology | 2017
Nuray Can; Mehmet Celik; Buket Yilmaz Bulbul; Necdet Sut; Filiz Ozyilmaz; Semra Ayturk; Sibel Guldiken; Nurtac Sarikas; Fulya Oz Puyan; Tulin Yalta; Ali Kemal Kutlu
OBJECTIVE Although pituitary adenomas have benign histomorphological features, some of them may present in an aggressive manner. To predict the behaviour of these tumours, telomerase reverse transcriptase (TERT) activity in pituitary adenomas has been the subject of a few studies with contradictory results. This study aims to investigate whether immunohistochemical expression of TERT differs in neoplastic and nonneoplastic pituitary tissues and aims to investigate whether TERT expression is related to clinicopathological features of pituitary adenomas. MATERIAL AND METHOD The study included 48 patients who had been diagnosed with pituitary adenomas and had clinical follow-ups. Nonneoplastic pituitary tissues were obtained from autopsy specimens (n=20). Immunohistochemistry for TERT antibody was performed. Both the nuclear and cytoplasmic expression of TERT antibody was noted, and total combined TERT staining was evaluated according to nuclear and cytoplasmic stainings. RESULTS TERT expression did not differ between neoplastic and nonneoplastic pituitary tissues. Neither total (combined nuclear and cytoplasmic) TERT nor nuclear TERT expression revealed any statistically significant relationship with any of the clinicopathological features. Higher cytoplasmic TERT expression was observed in adenomas with recurrence than adenomas without recurrence (p=0.035). CONCLUSION This study introduces the notion that immunohistochemical expression of TERT does not differ in neoplastic and nonneoplastic pituitary tissues. Pituitary adenomas with cytoplasmic immunohistochemical expression of TERT have significantly higher rates of recurrence. Further studies, including combined methods of immunohistochemistry and molecular analyses in larger groups, may reveal applicable results for the clinical significance of TERT in pituitary adenomas.
Turkish Journal of Pathology | 2014
Ebru Tastekin; Ufuk Usta; Aysegul Kaynar; Cigdem Ozdemir; Omer Yalcin; Filiz Ozyilmaz; Ali Kemal Kutlu
Abstract A congenital pulmonary airway malformation is a rare disorder of the pulmonary airway and a hamartomatous mass of disorganized lung tissues with various degrees of cystic change. A 20-year-old pregnant woman who did not have previous clinical follow-up during her pregnancy visited the gynecology department for her first check on the 19th week of gestation. The sonogram, showed severe hydrops fetalis. Laboratory findings were consistent with non-immune hydrops fetalis. Medical abortion was performed and the fetus was sent to our department for a complete fetal autopsy. Macroscopically, whole parts of the fetus had striking oedema. Massive pleural and peritoneal effusions were seen on dissection. The left lung filled the whole thoracic cavity. The heart was displaced to the right and the right lung was compressed. Microscopically, the left lung mass showed dilated bronchiole-like structures (1-20 mm) that were lined with ciliated columnar cells without any intervening mucinous cells. The subepithelial stroma contained thin, interrupted smooth muscle fibers and elastic connective tissue without cartilage plates. Our case is a very good example of non-immune hydrops fetalis associated with congenital pulmonary airway malformation type 2. Prenatal clinical and ultrasonographic follow-ups during pregnancy are very important for early diagnosis of congenital malformations.
Annals of Hepatology | 2012
Ebru Tastekin; Ufuk Usta; Turan Ege; Gokhan Kazindir; Ali Kemal Kutlu
Saudi Medical Journal | 2014
Ufuk Usta; Ebru Tastekin; Erhan Isler; Ali Kemal Kutlu; Fulya Oz Puyan
Chest | 2015
Ebru Tastekin; Inci Kutlu; Fulya Oz Puyan; Ali Kemal Kutlu
European Respiratory Journal | 2013
Ferhan Özşeker; Ismet Bulut; Füsun Erdenen; Aslı Gelincik; Derya Erdogdu; Ramazan Ersoy; Ali Kemal Kutlu; Fahrettin Talay; Bahattin Çolakoğlu; Suna Büyüköztürk
Chest | 2013
Zeynep Ferhan Ozseker; Ismet Bulut; Derya Erdogdu; Aslı Gelincik; Füsun Erdenen; Ramazan Ersoy; Ali Kemal Kutlu; Fahrettin Talay; Bahattin Çolakoğlu; Suna Büyüköztürk
Archive | 2010
T. Yalta; F. Oz Puyan; Ebru Tastekin; Ufuk Usta; T. Ciftci; Ali Kemal Kutlu; Tulin Yalta
Balkan Medical Journal | 2010
Ufuk Usta; Fulya Oz Puyan; Nuray Can; Ali Kemal Kutlu; Atakan Sezer