Ali Koşar

Suppression of Boiling Flow Oscillations in Parallel Microchannels by Inlet Restrictors

parallel channel and upstream compressible volume instabilities commonly exhibited during flow boiling in parallel microchannels have been investigated. The heat fluxes at the onset of unstable boiling have been obtained over effective heat fluxes ranging from 9t o614 W/cm 2 and mass fluxes from 115 to 389 kg/m 2 s. A dimensionless parameter M, which accounts for the pressure drop increase imposed by the inlet restrictors, has been used to correlate the extent of flow instability suppression. It has been shown that the onset of unstable boiling asymptotically increases with M. At sufficiently high M values, parallel channels and upstream compressible volume instabilities are completely eradicated although it gives way to another instability to develop, namely, the critical heat flux conditions. A correlation has been developed in terms of M to predict the conditions leading to unstable boiling. DOI: 10.1115/1.2150837

Thermal-Hydraulic Performance of MEMS-based Pin Fin Heat Sink

An experimental study on heat transfer and pressure drop of de-ionized water over a hank of shrouded staggered micro pin fins 243 μm long with hydraulic diameter of 99.5 μm has been performed. Average heat transfer coefficients have been obtained for effective heat fluxes ranging from 3.8 to 167 W/cm 2 and Reynolds numbers from 14 to 112. The results were used to derive the Nusselt numbers, total thermal resistances, and friction factors. It has been found that for Reynolds numbers below ∼50 long tube correlations overpredicted the experimental Nusselt number, while at higher Reynolds numbers existing correlations predicted the results moderately well. Endwall effects, which diminish at high Reynolds numbers, and a delay in flow separation for compact pin fins were attributed to the obtained trend.

Laminar Flow Across a Bank of Low Aspect Ratio Micro Pin Fins

Pressure drops and friction factors associated with the forced flow of de-ionized water over staggered and in-line circular/diamond shaped micro pin-fin bundles 100 μm long with hydraulic diameter of 50 and 100 μm have been experimentally investigated over Reynolds number ranging from 5 to 128. Pin fins were arranged according to two different horizontal and vertical pitch ratios (1.5 and 5). The applicability of conventional scale correlations to evaluate micro flow tests results has been assessed

Bubble Dynamics During Boiling in Enhanced Surface Microchannels

An experimental investigation is presented on flow boiling of deionized water in 227-mum hydraulic diameter microchannels with reentrant type cavities. Key features of nucleate boiling are discussed. Active nucleation site density, bubble frequency and departure diameter, and flow patterns over mass velocities ranging from 41 kg/m2-s to 302 kg/m2-s and heat fluxes ranging from 28 to 445 W/cm2 are studied. Similarities and differences with results obtained on large-scale systems and unenhanced microchannels are discussed

Reduced Pressure Boiling Heat Transfer in Rectangular Microchannels With Interconnected Reentrant Cavities

Boiling flow of deionized water through 227 μm hydraulic diameter microchannels with 7.5 μm wide interconnected reentrant cavities at 47 kPa exit pressure has been investigated. Average two-phase heat transfer coefficients have been obtained over effective heat fluxes ranging from 28 to 445 W/cm 2 and mass fluxes from 41 to 302 kg/m 2 s. A map is developed that divides the data into two regions where the heat transfer mechanisms are nucleation or convective boiling dominant. The map is compared to similar atmospheric exit pressure data developed in a previous study. A boiling mechanism transition criterion based on the Reynolds number and the Kandlikar k 1 number is proposed.

Critical Heat Flux of R-123 in Silicon-Based Microchannels

Critical heat flux (CHF) of R-123 in a silicon-based microchannel heat sink was investigated at exit pressures ranging from 227 kPa to 520 kPa. Critical heat flux data were obtained over effective heat fluxes ranging from 53 W/cm 2 to 196 W/cm 2 and mass fluxes from 291 kg/m 2 s to 1118 kg/m 2 s. Flow images and high exit qualities suggest that dryout is the leading CHF mechanism. The effect of mass velocity, exit quality, and system pressure were also examined, and a new correlation is presented to represent the effect of these parameters.

TCPT-2006-096.R2: Micro Scale pin fin Heat Sinks —Parametric Performance Evaluation Study

A parametric study of heat transfer and pressure drop associated with forced flow of deionized water over five micro pin fin heat sinks of different spacing, arrangements, and shapes was conducted experimentally. Nusselt numbers and friction factors were obtained over Reynolds numbers ranging from 14 to 720. The thermal and hydraulic results were obtained to evaluate and compare the heat sinks performances at fixed mass flow rate, fixed pressure drop, and fixed pumping power. Two distinct regions of the Nusselt number dependency on the Reynolds number separated by a critical Reynolds number have been identified for unstreamlined pin fin devices while the streamlined device showed no slope change. The effects of spacing, shape of pin fins, and arrangement on friction factor and heat transfer were in agreement with existing literature. The results indicate that utilizing streamlined pin fin heat sinks can significantly enhance the thermal-hydraulic performance of the heat sink, but only at moderate Reynolds numbers.

Cavitation Enhanced Heat Transfer in Microchannels

Heat transfer has been investigated in the presence of hydrodynamic cavitation instigated by 20-μm wide inlet micro-orifices entrenched inside 227-/μm hydraulic diameter microchannels. Average surface temperatures, heat transfer coefficients, and pressure drops have been obtained over effective heat fluxes ranging from 39 to 558 W/cm 2 at mass flux of 1814 kg/m 2 s under noncavitating and three cavitating conditions. Significant heat transfer enhancement has been recorded during supercavitating flow conditions in comparison to noncavitating flows with minimal pressure drop penalty. Once supercavitating conditions were reached, no apparent heat transfer augmentation was detected with the reduction of the cavitation index. Visualization of the flow morphology and the heat transfer coefficient characteristics aided in the evaluation of the dominant heat transfer mechanism under various thermal-hydraulic conditions.

MIR376A Is a Regulator of Starvation-Induced Autophagy

Background Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles. Abnormalities of the autophagic activity may result in the accumulation of protein aggregates, organelle dysfunction, and autophagy disorders were associated with various diseases. Hence, mechanisms of autophagy regulation are under exploration. Methods Over-expression of hsa-miR-376a1 (shortly MIR376A) was performed to evaluate its effects on autophagy. Autophagy-related targets of the miRNA were predicted using Microcosm Targets and MIRanda bioinformatics tools and experimentally validated. Endogenous miRNA was blocked using antagomirs and the effects on target expression and autophagy were analyzed. Luciferase tests were performed to confirm that 3′ UTR sequences in target genes were functional. Differential expression of MIR376A and the related MIR376B was compared using TaqMan quantitative PCR. Results Here, we demonstrated that, a microRNA (miRNA) from the DLK1/GTL2 gene cluster, MIR376A, played an important role in autophagy regulation. We showed that, amino acid and serum starvation-induced autophagy was blocked by MIR376A overexpression in MCF-7 and Huh7 cells. MIR376A shared the same seed sequence and had overlapping targets with MIR376B, and similarly blocked the expression of key autophagy proteins ATG4C and BECN1 (Beclin 1). Indeed, 3′ UTR sequences in the mRNA of these autophagy proteins were responsive to MIR376A in luciferase assays. Antagomir tests showed that, endogenous MIR376A was participating to the control of ATG4C and BECN1 transcript and protein levels. Moreover, blockage of endogenous MIR376A accelerated starvation-induced autophagic activity. Interestingly, MIR376A and MIR376B levels were increased with different kinetics in response to starvation stress and tissue-specific level differences were also observed, pointing out to an overlapping but miRNA-specific biological role. Conclusions Our findings underline the importance of miRNAs encoded by the DLK1/GTL2 gene cluster in stress-response control mechanisms, and introduce MIR376A as a new regulator of autophagy.

The Effect of Micro Pin-Fin Shape on Thermal and Hydraulic Performance of Micro Pin-Fin Heat Sinks

Single micro pin-fin configurations having the same chord thickness/diameter but different shapes are numerically modeled to assess their heat transfer and hydraulic performances for Reynolds number values changing between 20 and 120. The configurations are three-dimensionally modeled based, and their heat transfer performances are evaluated using commercially available software COMSOL Multiphysics 3.5a. Navier–Stokes equations and continuity and energy equations are solved under steady-state conditions for single-phase water flows. To increase the computational efficiency, half of the domain consisting of a micro pin-fin located inside a microchannel is modeled using a symmetry plane. To validate the model, experimental data available in the literature are compared to simulation results obtained from the model of the same geometrical configuration as the experimental one. Accordingly, the numerical and experimental results show good agreement. Furthermore, performance evaluation study is performed using three-dimensional (3D) numerical models in the light of flow morphologies around micro pin-fins of various shapes. According to the results obtained from this study, the rectangular-shaped micro pin-fin configuration has the highest Nusselt number and friction factor over the whole Reynolds number range. However, the cone-shaped micro pin-fin configuration has the best thermal performance index, indicating that it could be more preferable to use micro pin-fins of unconventional shapes in micro pin-fin heat sinks.