Ali Reza Khoshdel
Aja University of Medical Sciences
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Featured researches published by Ali Reza Khoshdel.
Reproductive Toxicology | 2013
Mohammad Reza Safarinejad; Seyyed Alaeddin Asgari; Alireza Farshi; Gholamhossein Ghaedi; Ali-Asghar Kolahi; Shahrokh Iravani; Ali Reza Khoshdel
We evaluated the effects of opiate consumption on semen quality, sperm function, seminal plasma antioxidant capacity, and sperm DNA integrity. A total of 142 opiate addict men (group 1) were enrolled in the study and 146 healthy age matched male volunteers (group 2) served as controls. Two semen analyses were performed in all participants. Sperm chromatin structure assay (SCSA) was used to identify sperm DNA integrity. The mean±SD sperm concentration in opiate users and in control subjects was 22.2±4.4 and 66.3±8.3 million per ml, respectively (P=0.002). A significant increase in the amount of fragmented DNA was found in opiate consumers compared with that in controls (36.4±3.8% vs. 27.1±2.4%, P=0.004). Significantly decreased levels of catalase-like and superoxide dismutase-like (SOD) activity were observed in group 1 compared with group 2. Opiate consumption has significant adverse effects on semen quality. In cases of unexplained infertility in men, opium consumption should be considered as a possible factor.
Obesity Research & Clinical Practice | 2017
Parvin Ghareghani; Mehrnoosh Shanaki; Saeideh Ahmadi; Ali Reza Khoshdel; Neda Rezvan; Reza Meshkani; Maryam Delfan; Sattar Gorgani-Firuzjaee
Due to changes in life style, obesity and obesity related complication such as insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease caused worldwide health problems. Regular exercise has been frequently prescribed to combat metabolic complication of obesity but its molecular mechanism has not been fully illustrated. We investigated molecular mechanism of lipid lowering effect of exercise training in high fat diet fed mice by focusing on miR-33 expression and autophagy pathway. 24 mice were assigned to normal chow (NC) (n=8), high-fat diet (HFD) (n=16) group and subjected to NC and HFD for 13-weeks. HFD groups were divided to sedentary (HFD n=8) or continuous endurance training (HFD+CET, n=8) subgroups. The HFD+CET mice were subjected to treadmill running for 10-weeks in 23-week HFD course. HFD increased body weight, fasting blood sugar, triglyceride, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), liver lipogenic genes expression and reduced miR-33 mRNA expression and autopahgy pathway while training program reversed them. Exogenous miR-33 mimic sequence induced autophagy and reduced lipogenesis in HepG2 cells. Autophagy induction by rapamycin reduced lipogenesis and autophagy inhibition by chloroquine, enhanced lipogenesis in HepG2 cells. These findings suggest that aerobic exercise training as a non-pharmacological therapy exerts its lipid lowering effects by miR-33 dependent autophagy induction.
Journal of Renal Nutrition | 2009
Abbas Basiri; Nasser Shakhssalim; Ali Reza Khoshdel; Mohammad Hadi Radfar; Hamid Pakmanesh
OBJECTIVE We evaluated the relationship between dietary regimen and the incidence of urolithiasis in various regions. DESIGN This was a population-based, cross-sectional study. SETTING The setting involved 787 imaging centers in 12 socioeconomic regions in Iran. PATIENTS AND METHODS Using a multistage, stratified sampling during 4 seasonal phases, 6127 cases of urolithiasis were detected from referrals to 787 radiology centers in 30 provinces across Iran. The dietary style of the provinces was obtained from an accredited registry, and its relationship with the incidence of urolithiasis in the same region was evaluated by meta-regression models. RESULTS No significant relationship was detected between urolithiasis incidence and daily intake of calcium, sodium chloride, or dairy products in univariate models. In contrast, the daily consumption of meat and protein had a significant correlation with the regional incidence of urolithiasis. Meat consumption had a direct correlation with the incidence of urolithiasis. Protein intake had a significant U-shaped correlation with the incidence of urolithiasis, indicating a high incidence in regions with a high-protein diet, as well as with a low-protein diet. The proportion of meat consumption to total protein intake was similar in both regions, and higher than in regions with a medium-protein intake and low incidence of urolithiasis. CONCLUSION A high proportion of meat consumption, in conjunction with either a low or high total protein intake, was correlated with a high regional incidence of urolithiasis.
BMC Cancer | 2015
Rezvan Esmaeili; Keivan Majidzadeh-A; Leila Farahmand; Maryam Ghasemi; Malihe Salehi; Ali Reza Khoshdel
BackgroundCancer-testis antigens are among the new promising biomarkers, especially for targeted therapy. Aberrant and specific expression of these proteins has been reported in some tumor tissues. Also understanding their differential role in normal and cancer tissues may introduce them as new candidates for biomarker in cancer.MethodsAKAP3 expression was investigated in 162 tumors, normal adjacent and normal tissues of the breast with Real-Time PCR. Also the correlation between the gene expression and clinico-pathologic features of the tumors and treatment regimen was evaluated.ResultsThere was an association between lack of AKAP3 expression in tumor tissues and triple negative status (p=. 03). There was also a correlation between lack of this marker and tumor size (p = .01) and stage (p = .04). Lack of AKAP3 in normal adjacent tissues was associated with poor prognosis. Kaplan Meier plot demonstrated a remarkable better 5-year disease free survival in AKAP3 positive normal adjacent group.ConclusionsIt was found that this relationship is originated from the difference in AKAP3 expression, not therapy distribution between two groups of patients. Thus, it may be a proper biomarker candidate for triple negative breast cancer patients. Also, testing AKAP3 in normal tissue of the patients may be used to predict the outcome of the treatment.
Urological Research | 2011
Abbas Basiri; Nasser Shakhssalim; Ali Reza Khoshdel; Mahdi Mansouri
Seasonal variations of renal colics and urolithiasis: is this the time for a shared benchmark to study the phenomenon?
Wilderness & Environmental Medicine | 2015
Seyed Mostafa Monzavi; Amir Ahmad Salarian; Ali Reza Khoshdel; Bita Dadpour; Reza Afshari
OBJECTIVE This study was designed to evaluate the effectiveness of a new protocol implemented to standardize snakebite management in Iran. METHODS In this study, 27 patients treated according to the new protocol in 2012 (P+) were compared with 22 patients treated according to the previous modality in the year before implementation of the protocol (P-) in Mashhad Medical Toxicology Centre (MTC). Demographic characteristics and treatment details of all patients were recorded prospectively. Envenomation severity of each victim was assessed according to snakebite severity score (SSS). RESULTS After implementation of the protocol, a smaller percentage of patients received antivenom (AV) therapy (78% vs 95%; P=.079). In spite of no significant difference in baseline severity of envenomation between the 2 groups (SSS [mean±SD], 34.8±18.1 vs 35.5±17.4; P=.801), the P+ group received significantly fewer AV vials (8.4±6.8 vs 12.1±5.6 vials; P=.042) and had a significantly shorter length of hospital stay (2.2±1.5 vs 3.2±1.8 days; P=.027). Moreover, smaller proportion of P+ patients experienced recurrence of venom-induced effects; however, the difference was not significant (18.5% vs 36%; P=.159). The reduction in use of antiallergy treatments to prevent or treat acute hypersensitivity reactions approached statistical significance (41% vs 68%; P=.051). These findings denote a reduction in AV use of approximately 4 vials and a reduction in hospital stay of 1 day for each patient, which translates to approximately
Noise & Health | 2016
Ali Reza Khoshdel; Benyamin Mousavi-Asl; Babak Shekarchi; Kazem Amini; Iraj Mirzaii-Dizgah
196/patient in healthcare cost savings. CONCLUSIONS Implementation of a snakebite management protocol at MTC reduced overall antivenom usage, use of antiallergy interventions, and length of hospital stay.
Annals of Epidemiology | 2016
Arash Nazeri; Abdolreza Salahi-Moghadam; Ali Reza Khoshdel; Mahtab Noorifard
Background: Chronic exposure to noise is known to cause a wide range of health problems including extracellular matrix (ECM) proliferation and involvement of cardiovascular system. There are a few studies to investigate noise-induced vascular changes using noninvasive methods. In this study we used carotid artery intima-media thickness (CIMT) and aortic augmentation as indices of arterial properties and cystatin C as a serum biomarker relating to ECM metabolism. Materials and Methods: Ninety-three male participants were included in this study from aeronautic technicians: 39 with and 54 without a history of wide band noise (WBN) exposure. For better discrimination, the participants were divided into the two age groups: <40 and >40 years old. Adjusted aortic augmentation index (AI) for a heart rate equal to 75 beats per minute (AIx@HR75) were calculated using pulse wave analysis (PWA). CIMT was measured in 54 participants who accepted to undergo Doppler ultrasonography. Serum cystatin C was also measured. Results: Among younger individuals the mean CIMT was 0.85 ± 0.09 mm and 0.75 ± 0.22 mm in the in the exposed and the control groups respectively. Among older individuals CIMT had a mean of 1.04 ± 0.22 mm vs. 1.00 ± 0.25 mm for the exposed vs. the control group. However, in both age groups the difference was not significant at the 0.05 level. A comparison of AIx@HR75 between exposure group and control group both in younger age group (5.46 ± 11.22 vs. 8.56 ± 8.66) and older age group (17.55 ± 10.07 vs. 16.61 ± 5.77) revealed no significant difference. We did not find any significant correlation between CIMT and AIx@HR75 in exposed group (r = 0.314, P value = 0.145) but the correlation was significant in control group (r = 0.455, P value = 0.019). Serum cystatin C level was significantly lower in individuals with WBN exposure compared to controls (441.10 ± 104.70 ng/L vs. 616.89 ± 136.14, P value < 0.001) both in younger and older groups. Conclusion: We could not find any evidence for the association of WBN exposure with arterial properties, but cystatin C was significantly lower in the exposed group.
Urology Journal | 2008
Ali Reza Khoshdel; Shane Carney
PURPOSE Social networks are increasingly being used to study the epidemiology of human diseases. These methods are usually limited to studying a single or a small group of diseases within a small community and may not fully capture effects of environmental factors that drift the epidemiology of diseases at the community level (rather than individual level). By introducing an ecological variant of the social network, we described provincial disease network (PDN) to study the similarities in regional occurrence of diseases. METHODS In this network, nodes (provinces) are connected via edges together. Provinces that have similar pattern of disease prevalence and/or incidence tie stronger together. We sought to find modular organization of Irans PDN and to identify factors (literacy, rural population percentage, smoking, geographical distance, and age distribution) that could predict the strength of interprovincial connections in the PDN. RESULTS Provinces in Irans PDN were segregated into five different modules. Geographic distance, differences in the literacy percentage and percentage of population in the 0-16 years age group showed significant inverse correlation with strength of connections in Irans PDN. CONCLUSIONS Network-based approaches could provide important insights by identifying modular architecture within the PDN and underlying factors that drive similarity between disease patterns among regional entities.
International Urology and Nephrology | 2010
Abbas Basiri; Nasser Shakhssalim; Ali Reza Khoshdel; Seyed Mohammad Ghahestani; Hossein Basiri