Ali Tosun

Synthesis and anticonvulsant activity of 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(o/p-substituted benzal) hydrazone derivatives.

It is well known that some hydrazone derivatives of both 2-oxobenzoxazoline and 2-oxobenzothiazoline exhibit potent anticonvulsant activity. In order to investigate the effects of structural modifications on the biological properties, 14 new hydrazones of 5-chloro-2(3H)-benzox-azolinone-3-acetyl hydrazide were synthesized. The chemical structures of the synthesized compounds were established by IR, 1H-NMR spectral analyses and elementary analyses. The anticonvulsant activities of the title compounds were tested by the penthylenetetrazole induced seizure test. 5-Chloro-2(3H)-benz-oxazolinone-3-acetyl-2-(o-methoxy-benzaldehyde)-hydrazone 4d, 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(o-methybenzaldehyde)-hydrazone 4g, 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(p-methylbenzaldehyde)-hydrazone 4h, 5-chloro-2(3H)-benzoxazolino-ne-3-acetyl-2-(p-nitrobenzaldehyde)-hydrazone 4m, and 5-chloro-2(3H)-benzox-azolinone-3-acetyl-2-(p-dimethylaminobenzaldehyde)-hydrazone 4n were found more active than phenytoin (CAS 57-41-0) in the tests.

10α-hydroxymethylsparteine, a new type of quinolizidine alkaloid from Genista sessilifolia

10α-Hydroxymethylsparteine (1), a novel type of quinolizidine alkaloid with a 16-carbon atom skeleton, was isolated from the aerial parts of Genista sessilifolia DC. The position of the hydroxymethyl substituent and the stereochemistry of compound 1 were established by analysis of its spectroscopic data.

Quantitavive Proton Magnetic Resonance Analysis of Ranitidine in Solid Dosage Forms

Abstract A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d6 served as the PMR solvent. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of ranitidine hydrochloride at 4.32 δ ppm and int. st. at 5.19 δ ppm. The method using commercial products gave comparable results to those obtained by the methods of UV spectroscopy and USP XXIII.

Quantitative Proton Magnetic Resonance Analysis of Primidone in Solid Dosage Forms

Abstract A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining primidone in tablets. Maleic acid was used as the internal standart and DMSO-d6 served as the PMR solvent.

Synthesis and Analgesic Activity of 1‐(1‐Piperidinyl)methyl‐2‐(4‐substituted styryl)‐5‐chlorobenzimidazole Derivatives

Seven 1-(1-piperidinyl)methyl-2-(4-substituted styryl)-5-chlorobenzimidazole derivatives were synthesized by the reaction of 2-(p-substituted styryl)-5-chlorobenzimidazoles with formaldehyde and piperidine in methanol. Analgesic activity of the 1-(1-piperidinyl)-methyl-2-(4-substituted styryl)-5-chlorobenzimidazole derivatives was investigated by the modified Koster test in mice. No obvious relationships between analgesic activity and the nature of the substituent on the styryl group was found.