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Dive into the research topics where Aline Lira Xavier is active.

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Featured researches published by Aline Lira Xavier.


The Scientific World Journal | 2014

Antitumor Activity of Monoterpenes Found in Essential Oils

Marianna Vieira Sobral; Aline Lira Xavier; Tamires Cardoso Lima; Damião Pergentino de Sousa

Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes. In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed. Chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.


Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy | 2007

The controvertible role of kava (Piper methysticum G. Foster) an anxiolytic herb, on toxic hepatitis

Maria de Fátima Duques de Amorim; Margareth de Fátima Formiga Melo Diniz; Maria Salete Trigueiro de Araújo; João Carlos Lima Rodrigues Pita; Jadson Gomes Dantas; Josué do Amaral Ramalho; Aline Lira Xavier; Thayse V. Palomaro; Nelson L. B. Júnior

Kava is an anxiolytic herbal medicine used in the treatment of sleep and anxiety disorders. Some cases of kava-induced hepatotoxicity have been reported in the literature leading to its banishment in most countries worldwide. Clinically, the spectrum ranged from transient elevations of liver enzyme levels to fulminant liver failure and death. Liver transplantation was performed in a few cases. This paper provides a review of the currently available literature on kava-related toxic hepatitis which may result from its use, discusses the possible mechanisms for the potentially severe hepatotoxicity and describes some features which must be considered when adverse liver effects seem to be associated to kava administration. In conclusion, the incidence of kava toxicity on the liver remains to be investigated; however, some concerns before or during kava use are important, due to the possibility of severe liver dysfunction.


Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy | 2008

Constituintes químicos, avaliação das atividades citotóxica e antioxidante de Mimosa paraibana Barneby (Mimosaceae)

Xirley P. Nunes; Rafael F. Mesquita; Davi Antas e Silva; Daysianne Pereira de Lira; Vicente Carlos de Oliveira Costa; Marianna Vieira Barreto Silva; Aline Lira Xavier; Margareth de Fátima Formiga Melo Diniz; Maria de Fátima Agra

The phytochemical study of Mimosa paraibana Barneby led to the isolation of its chemical constituents, through the usual chromatographic methods, and further structural identification, using 1H and 13C NMR spectroscopic methods based on one and two-dimensional techniques, in addition to comparison with literature data. From this pioneering investigation with M. paraibana, five constituents were isolated and identified from the chloroform extract: a mixture of β-sitosterol and stigmasterol, 151-hydroxy-phaeophytin A, 5,7-dihydroxyflavanone, ethyl 3,4,5-trihydroxybenzoate and p-coumaric acid. The antioxidant activity of the hexane, chloroform and ethyl acetate extracts of M. paraibana were measured using the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay and the results compared with standard ascorbic acid. The toxicity activity of the extracts were performed using the bioassay of Artemia salina.


Molecules | 2012

In vitro and in vivo antitumor effect of trachylobane-360, a diterpene from Xylopia langsdorffiana.

João Carlos Lima Rodrigues Pita; Aline Lira Xavier; Tatyanna Kelvia Gomes de Sousa; Vivianne Mendes Mangueira; Josean Fechine Tavares; Robson José de Oliveira Júnior; Robson Cavalcante Veras; Hilzeth de Luna Freire Pessôa; Marcelo Sobral da Silva; Sandra Morelli; Veridiana de Melo Rodrigues Ávila; Teresinha Gonçalves da Silva; Margareth de Fátima Formiga Melo Diniz; Marianna Vieira S. Castello-Branco

Trachylobane-360 (ent-7α-acetoxytrachyloban-18-oic acid) was isolated from Xylopia langsdorffiana. Studies have shown that it has weak cytotoxic activity against tumor and non-tumor cells. This study investigated the in vitro and in vivo antitumor effects of trachylobane-360, as well as its cytotoxicity in mouse erythrocytes. In order to evaluate the in vivo toxicological aspects related to trachylobane-360 administration, hematological, biochemical and histopathological analyses of the treated animals were performed. The compound exhibited a concentration-dependent effect in inducing hemolysis with HC50 of 273.6 µM, and a moderate in vitro concentration-dependent inhibitory effect on the proliferation of sarcoma 180 cells with IC50 values of 150.8 µM and 150.4 µM, evaluated by the trypan blue exclusion test and MTT reduction assay, respectively. The in vivo inhibition rates of sarcoma 180 tumor development were 45.60, 71.99 and 80.06% at doses of 12.5 and 25 mg/kg of trachylobane-360 and 25 mg/kg of 5-FU, respectively. Biochemical parameters were not altered. Leukopenia was observed after 5-FU treatment, but this effect was not seen with trachylobane-360 treatment. The histopathological analysis of liver and kidney showed that both organs were mildly affected by trachylobane-360 treatment. Trachylobane-360 showed no immunosuppressive effect. In conclusion, these data reinforce the anticancer potential of this natural diterpene.


Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy | 2009

Preliminary study of the molluscicidal and larvicidal properties of some essential oils and phytochemicals from medicinal plants

Aristides Medeiros Leite; Edeltrudes de Oliveira Lima; Evandro Leite de Souza; Margareth de Fátima Formiga Melo Diniz; Sônia Pereira Leite; Aline Lira Xavier; Isac Almeida de Medeiros

This study aimed to evaluate the molluscicidal and larvicidal activity of some essential oils and phytochemicals from medicinal plants. Molluscicide and larvicidal activity were determined by, respectively, the lethality bioassays using Artemia salina Leach. Artemiidae and Aedes aegypti L. Culicidae larvae. Essential oils from Eugenia uniflora L. Myrtaceae, Laurus nobilis L. Lauraceae, Origanum vulgare L. Lamiaceae and the phytochemicals α-pinene and eugenol presented citotoxicity toward Artemia salina with CL50 values between 9.59 and 253.43 μL/mL. Essential oils from E. uniflora, M. piperita, O. vulgare and R. officinalis showed embryotoxicity on Aedes aegypti larvae with a viability inhibition between 40 and 100%. These results show the bioactivity of the assayed essential oils and phytochemicals and, partially, justify their insertion in further evaluation in order to establish a safe exploitation of their biological potentiality.


Pharmaceutical Biology | 2016

Essential oil from fruit of Xylopia langsdorffiana: antitumour activity and toxicity

Ana Paula Gomes Moura; Daiene Martins Beltrão; João Carlos Lima Rodrigues Pita; Aline Lira Xavier; Monalisa Taveira Brito; Tatyanna Kelvia Gomes de Sousa; Leônia Maria Batista; João Ernesto de Carvalho; Adriana Della Torre; Marcelo Cavalcante Duarte; Josean Fechine Tavares; Marcelo Sobral da Silva; Marianna Vieira Sobral

Abstract Context: The genus Xylopia L. (Annonaceae) includes aromatic plants that have both nutritional and medicinal uses. Essential oils of Xylopia species have antitumour effects. However, the efficacy of the essential oil from the fruit of Xylopia langsdorffiana St. Hil & Tul. (EOX) has not been examined. Objective: EOX was evaluated to determine its chemical composition, antitumour activity and toxicity. Materials and methods: EOX was obtained from fresh fruits of X. langsdorffiana subjected to hydrodistillation, and gas chromatography-mass spectrometry was used to characterize the chemical composition of EOX. The toxicity of EOX was evaluated using haemolysis, acute toxicity and micronucleus assays. The in vitro antitumour activity of EOX was investigated using the sulforhodamine B assay. The sarcoma 180 murine tumour model was used to evaluate the in vivo antitumour activity and toxicity of EOX (50 and 100 mg/kg) after 7 d of treatment. Results: The major components of EOX were α-pinene (34.57%) and limonene (31.75%). The HC50 (concentration producing 50% haemolysis) was 293.6 μg/ml. EOX showed greater selectivity for the leukaemia cell line K562, with total growth inhibition (TGI) (concentration producing TGI) of 1.8 μg/ml, and for multidrug-resistant ovarian tumour cell line NCI/ADR-RES (TGI of 45.4 μg/ml). The LD50 was approximately 351.09 mg/kg. At doses of 50 and 100 mg/kg, EOX inhibited the in vivo growth of sarcoma 180 by 38.67 and 54.32%, respectively. EOX displayed minor hepatic alterations characteristic of acute hepatitis and induced no genotoxicity. Conclusion: EOX showed in vitro and in vivo antitumour activity and low toxicity, which warrants further pharmacological studies.


Zeitschrift für Naturforschung C | 2015

Chemical composition, antitumor activity, and toxicity of essential oil from the leaves of Lippia microphylla.

Aline Lira Xavier; João Carlos Lima Rodrigues Pita; Monalisa Taveira Brito; Déborah R.P. Meireles; Josean Fechine Tavares; Marcelo Sobral da Silva; José Guilherme S. Maia; Eloisa Helena A. Andrade; Margareth de Fátima Formiga Melo Diniz; Teresinha Gonçalves da Silva; Hilzeth de Luna Freire Pessôa; Marianna Vieira Sobral

Abstract The chemical composition, antitumor activity and toxicity of the essential oil from Lippia microphylla leaves (OEL) were investigated. The major constituents were thymol (46.5%), carvacrol (31.7%), p-cymene (9%), and γ-terpinene (2.9%). To evaluate the toxicity of OEL in non-tumor cells, the hemolytic assay with Swiss mice erythrocytes was performed. The concentration producing 50% hemolysis (HC50) was 300 μg/mL. Sarcoma 180 tumor growth was inhibited in vivo 38% at 50 mg/kg, and 60% at 100 mg/kg, whereas 5-FU at 50 mg/kg caused 86% inhibition. OEL displays moderate gastrointestinal and hematological toxicity along with causing some alteration in liver function and morphology. However, the changes were considered reversible and negligible in comparison to the effects of several anticancer drugs. In summary, OEL displays in vivo antitumor activity and a moderate toxicity, which suggests further pharmacological study.


Marine Drugs | 2017

Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical

Raquel Nogueira; Anna Cláudia de A. Tomaz; Déborah Pessoa; Aline Lira Xavier; João Carlos Lima Rodrigues Pita; Marianna Vieira Sobral; Marcela Zanella Ribeiro Pontes; Hilzeth de Luna Freire Pessôa; Margareth de Fátima Formiga Melo Diniz; George Emmanuel C. de Miranda; M.T. Vieira; Márcia Ortiz Mayo Marques; Maria Helena do Nascimento Souza; Emídio Vasconcelos Leitão da Cunha

Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance. Palmitic and linolenic acid were the main saturated and unsaturated acids, respectively. Cytotoxic and antioxidant activities were evaluated using human erythrocytes. In vivo evaluations of acute toxicity and genotoxicity were performed in mice. Methanolic extract of P. sanctae-crucis presented antioxidant activity and did not induce cytotoxicity, genotoxicity or acute toxicity. Since Padina sanctae-crucis is already used as food, has essential fatty acids for the nutrition of mammals, does not present toxicity and has antioxidant activity, it can be considered as a potential nutraceutical.


Experimental Biology and Medicine | 2016

Assessment of Pradosia huberi effects on the reproductive system of male rats

Elane Cristina Silva dos Santos; Priscylla Silva Antunes; Flávia Luana Pereira dos Santos; Aldeíde de Oliveira Batista Rocha; João Carlos Lima Rodrigues Pita; Aline Lira Xavier; Cibério Landim Macêdo; Kerollayne Christtine Jacob; Nayara Alves de Oliveira; Alessandra Azevedo Nascimento de Medeiros; Margareth de Fátima Formiga Melo Diniz; Rita de Cássia da Silveira e Sá

Pradosia huberi is a species found in the Amazon region and used as an antiulcerogenic and gastroprotective agent; however, phytochemical analysis has revealed the presence of compounds with potential toxic effects on the reproductive system. For the evaluation of the toxicity of P. huberi on male fertility, male Wistar rats were divided into four groups: one control (distilled water p.o.) and three treated (hydroalcoholic extract of the stem bark of P. Huberi (PH-HAE) at doses of 1.22, 6.1, and 30.5 mg/kg p.o.) once daily, for 63 days. In the last week of treatment (from the 57th to the 63rd day), the rats were mated with untreated virgin females (n = 30/group) and were killed on day 64. To investigate the toxic potential of PH-HAE on the reproductive system of rats the following parameters were evaluated: sperm production, genotoxicity, and general development. The production of gametes and their morphology did not differ between control and treated groups. Treatment with PH-HAE did not result in fewer vaginal plugs formed, indicating that the ability to mate was not impaired, but caused an increase of 14.3 and 10.8% in the preimplantation loss index, a reduction of 14.3 and 10.8% in the implantation index, and a reduction of 5.6 and 8.2% in the postimplantation loss index of female rats mated with rats treated with 6.1 and 30.5 mg/kg, respectively, indicating a possible toxic action of PH-HAE on the reproductive system of rats.


Química Nova | 2009

First secondary metabolites from Herissantia crispa L (Brizicky) and the toxicity activity against Artemia salina Leach

Danielly Albuquerque da Costa; Wemerson Neves Matias; Igara Oliveira Lima; Aline Lira Xavier; Vivian Bruna Machado Costa; Margareth de Fátima Formiga Melo Diniz; Maria de Fátima Agra; Leônia Maria Batista; Maria de Fátima Vanderlei de Souza; Davi Antas e Silva

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Marianna Vieira Sobral

Federal University of Paraíba

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Josean Fechine Tavares

Federal University of Paraíba

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Marcelo Sobral da Silva

Federal University of Paraíba

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Monalisa Taveira Brito

Federal University of Paraíba

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Tatianne Mota Batista

Federal University of Paraíba

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Daiene Martins Beltrão

Federal University of Paraíba

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