Allan E. Dumont

Hepatic suppression of sensitization to antigen absorbed into the portal system.

THE position of the liver between the gastrointestinal tract and the general circulation provides certain metabolic advantages. If, in addition, the liver functions to prevent sensitization to potential antigens contained in food and absorbed into the portal system, then this interposition is also immunologically important.

Flow rate and composition of thoracic-duct lymph in patients with cirrhosis.

IN the 1908 Christian Herter Lectures at Bellevue Hospital, Starling1 emphasized the important influence of changes in hepatic interstitial-fluid formation on flow and composition of thoracic-duct ...

LYMPH DRAINAGE IN PATIENTS WITH CONGESTIVE HEART FAILURE. COMPARISON WITH FINDINGS IN HEPATIC CIRRHOSIS.

UNDERSTANDING of the physiologic alterations present in patients with congestive heart failure is limited in part by incomplete knowledge concerning pathogenesis of elevated venous pressure and cir...

Lymph Circulation in Hepatic Cirrhosis: Effect of Portacaval Shunt

Abstract To determine the relative contribution of the liver and extrahepatic portal bed to increased flow of thoracic duct lymph in hepatic cirrhosis, thoracic duct lymph was examined in 84 patien...

Whipple's Disease: Identification of Circulating Whipple Cells in Thoracic Duct Lymph

Summary 1.A case of Whipples disease is reported. 2.The thoracic duct was cannulated and found to be patent although flow of chylous lymph was markedly reduced. 3.Macrophages with characteristic PAS-positive granules were found circulating in thoracic duct lymph. 4.A very high lymph: serum protein ratio was noted.

Platelet Blockade of Particle Absorption from the Peritoneal Surface of the Diaphragm

Abstract Particulate material is absorbed from the peritoneal cavity via respiration-induced gaps between mesothelial cells on the peritoneal surface of the diaphragm and is then collected into diaphragmatic and retrosternal lymph vessels. The effect of platelets on this process was examined by (i) comparing the appearance of these lymph vessels after intraperitoneal (ip) injection of Radiopaque or carbon particles in control and experimental rats receiving, respectively, an ip injection of either platelet-rich (PRP) or platelet-poor (PPP) plasma or saline solution 1 hr prior to the injection of particles; and by (ii) inspecting lymph vessels on the pleural side of 20 freshly excised pieces of rabbit or dog diaphragm (secured pleural side down, to the mouth of a suction flask) 5 min after application of India ink with either PRP or PPP (or saline) to the peritoneal surface. In each case injection or application of PRP either blocked or markedly restricted particle absorption. Electron microscopic (EM) observations indicate that platelets block absorption of particles by plugging gaps between adjacent mesothelial cells.

Siderosis of lymph nodes in patients with Hodgkin's disease

Lymph nodes removed from 28 untreated patients with Hodgkins disease all contained markedly increased amounts of hemosiderin, whether or not they were histologically involved in the disease. This finding was particularly striking in patients with the nodular sclerosis type of disease. Abnormal deposits of iron were also noted frequently in lymph nodes containing metastatic carcinoma, lymphoma of non‐Hodgkins type, and reactive hyperplasia, but in each case, with the exception of metastatic squamous cell carcinoma, the amount was significantly less than that seen in Hodgkins disease. The findings suggest that in patients with Hodgkins disease and perhaps in those with other disorders in which abnormal tissue retention of iron underlies sideropenic anemia, lymph nodes are an important site of iron retention.

Patterns of distribution of sulfobromophthalein in lymph and blood during obstruction to bile flow

Abstract New questions must be formulated concerning the events in obstructive jaundice; the old controversy as to whether bile regurgitates into lymph or into blood is no longer applicable. Blood as well as lymph transports excess BSP (and presumably bilirubin) from the obstructed liver. The importance of one route over the other depends on the form of the molecule and the duration of bile stasis.

Measurement of Pancreatic Enzymes in Human Thoracic Duct Lymph

Summary In patients whose thoracic ducts had been cannulated, the intravenous injection of secretin produced a marked rise in concentration of amylase and lipase of the lymph without significant changes in the serum levels of these enzymes. Morphine given with the secretin augmented the effect on lymph enzyme levels.

Interstitial Albumin-Bound Dye Concentrations in Mice with a Protein-Rich Effusion

Abstract Levels of intravenously injected Evans blue dye in eluates of the lung and kidney, an index of interstitial fluid albumin concentration, together with water content of these tissues and levels of serum albumin were measured in Ha-icr mice with a tumor cell-induced protein-rich peritoneal effusion. By the fourth day after the intraperitoneal injection of tumor cells, when mean serum albumin levels had fallen to 76% of control values, mean albumin bound dye concentrations in lung and kidney had decreased to 63 and 58%, respectively, of control values. By the tenth day when serum albumin levels had decreased further to 67% of control values, albumin-bound dye concentrations in the lung and kidney had decreased to 58 and 43%, respectively, of control values. During this 10-day period the water content of the lung remained unchanged whereas that of the kidney had decreased by 7%. These observations suggest that the reduction in serum albumin which results from an abnormal distribution of this protein into a nonvascular compartment is accompanied, as in other models of hypoalbuminemia, by a more than proportionate reduction in interstitial albumin concentration in the lung and kidney.